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Pesticide exposure and risk of Parkinson's disease--a population-based case-control study evaluating the potential for recall bias.
Scand J Work Environ Health 2011; 37(5):427-36SJ

Abstract

OBJECTIVE

The aim of this study was to investigate whether pesticide exposure was associated with Parkinson's disease in a population-based case-control study in British Columbia, Canada.

METHODS

Patients reimbursed for anti-parkinsonian agents were identified and screened for eligibility as cases. Controls were selected from the universal health insurance database, frequency-matched to the case sample on birth year, gender, and geographic region. A total of 403 cases and 405 controls were interviewed about their job, medical and personal habits histories, and beliefs about disease risk factors. Among those reporting pesticide exposure, an occupational hygiene review selected participants exposed "beyond background" (ie, above the level expected in the general population). Unconditional logistic regression was used to estimate associations for different pesticide categories.

RESULTS

Of the cases, 74 (18%) self-reported pesticide exposure and 37 (9%) were judged to be exposed beyond background. Self-reported exposure was associated with increased risk [odds ratio (OR) 1.76, 95% confidence interval (95% CI) 1.15-2.70], however the risk estimate was reduced following the hygiene review when restricted to those considered exposed (OR, 1.51, 95% CI, 0.85-2.69). When agricultural work was added to the model, the risk for hygiene-reviewed pesticide exposure was not elevated (OR 0.83, 95% CI 0.43-1.61), but agricultural work was (OR 2.47, 95% CI 1.18-5.15). More than twice as many cases as controls thought chemicals cause Parkinson's disease. Discussion This study provides little support for pesticide exposure as a cause of Parkinson's disease. The observed pattern of step-wise decreases in risk estimates might indicate differential recall by case status. The relationship to agricultural jobs suggests that farming exposures--other than pesticides--should be considered as risk factors for Parkinson's disease.

Authors+Show Affiliations

Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. rugbjerg@cancer.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21240453

Citation

Rugbjerg, Kathrine, et al. "Pesticide Exposure and Risk of Parkinson's Disease--a Population-based Case-control Study Evaluating the Potential for Recall Bias." Scandinavian Journal of Work, Environment & Health, vol. 37, no. 5, 2011, pp. 427-36.
Rugbjerg K, Harris MA, Shen H, et al. Pesticide exposure and risk of Parkinson's disease--a population-based case-control study evaluating the potential for recall bias. Scand J Work Environ Health. 2011;37(5):427-36.
Rugbjerg, K., Harris, M. A., Shen, H., Marion, S. A., Tsui, J. K., & Teschke, K. (2011). Pesticide exposure and risk of Parkinson's disease--a population-based case-control study evaluating the potential for recall bias. Scandinavian Journal of Work, Environment & Health, 37(5), pp. 427-36. doi:10.5271/sjweh.3142.
Rugbjerg K, et al. Pesticide Exposure and Risk of Parkinson's Disease--a Population-based Case-control Study Evaluating the Potential for Recall Bias. Scand J Work Environ Health. 2011;37(5):427-36. PubMed PMID: 21240453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pesticide exposure and risk of Parkinson's disease--a population-based case-control study evaluating the potential for recall bias. AU - Rugbjerg,Kathrine, AU - Harris,M Anne, AU - Shen,Hui, AU - Marion,Stephen A, AU - Tsui,Joseph K C, AU - Teschke,Kay, Y1 - 2011/01/17/ PY - 2011/1/18/entrez PY - 2011/1/18/pubmed PY - 2011/12/22/medline SP - 427 EP - 36 JF - Scandinavian journal of work, environment & health JO - Scand J Work Environ Health VL - 37 IS - 5 N2 - OBJECTIVE: The aim of this study was to investigate whether pesticide exposure was associated with Parkinson's disease in a population-based case-control study in British Columbia, Canada. METHODS: Patients reimbursed for anti-parkinsonian agents were identified and screened for eligibility as cases. Controls were selected from the universal health insurance database, frequency-matched to the case sample on birth year, gender, and geographic region. A total of 403 cases and 405 controls were interviewed about their job, medical and personal habits histories, and beliefs about disease risk factors. Among those reporting pesticide exposure, an occupational hygiene review selected participants exposed "beyond background" (ie, above the level expected in the general population). Unconditional logistic regression was used to estimate associations for different pesticide categories. RESULTS: Of the cases, 74 (18%) self-reported pesticide exposure and 37 (9%) were judged to be exposed beyond background. Self-reported exposure was associated with increased risk [odds ratio (OR) 1.76, 95% confidence interval (95% CI) 1.15-2.70], however the risk estimate was reduced following the hygiene review when restricted to those considered exposed (OR, 1.51, 95% CI, 0.85-2.69). When agricultural work was added to the model, the risk for hygiene-reviewed pesticide exposure was not elevated (OR 0.83, 95% CI 0.43-1.61), but agricultural work was (OR 2.47, 95% CI 1.18-5.15). More than twice as many cases as controls thought chemicals cause Parkinson's disease. Discussion This study provides little support for pesticide exposure as a cause of Parkinson's disease. The observed pattern of step-wise decreases in risk estimates might indicate differential recall by case status. The relationship to agricultural jobs suggests that farming exposures--other than pesticides--should be considered as risk factors for Parkinson's disease. SN - 1795-990X UR - https://www.unboundmedicine.com/medline/citation/21240453/Pesticide_exposure_and_risk_of_Parkinson's_disease__a_population_based_case_control_study_evaluating_the_potential_for_recall_bias_ L2 - http://www.sjweh.fi/show_abstract.php?abstract_id=3142 DB - PRIME DP - Unbound Medicine ER -