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Long-term contraception with the levonorgestrel 20 mcg/day (LNg 20) and the copper T 380Ag intrauterine devices: a five-year randomized study.
Contraception. 1990 Oct; 42(4):361-78.C

Abstract

An intrauterine device, releasing approximately 20 micrograms/day of levonorgestrel (LNg 20), used by 1124 women, was studied in a randomized trial of five years duration in comparison with the Copper T, model TCu 380Agm in 1121 women. At five years, the gross cumulative pregnancy rate of 1.1 +/- 0.5 per 100 among users of the LNg 20 devices was not significantly different from the rate of 1.4 +/- 0.4 per 100 experienced by users of the Copper T 380Ag. The steroid-releasing IUD had significantly higher termination rates for expulsion and amenorrhea, a significantly lower termination rate for other menstrual problems and pain, and a lower continuation rate. The five-year continuation rate among women using the TCu 380Ag was 40.6 per 100 as compared with that of 33.0 per 100 among women randomized to the LNg 20 device (P less than .001). Terminations attributed to amenorrhea with the LNg device primarily account for differences in continuation. These two intrauterine devices are the most effective long-term, reversible IUDs yet reported in the literature. No other contraceptive methods have exhibited such low long-term pregnancy rates in randomized comparative trials.

Authors+Show Affiliations

Center for Biomedical Research, Population Council, New York, NY 10021.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2124179

Citation

Sivin, I, et al. "Long-term Contraception With the Levonorgestrel 20 Mcg/day (LNg 20) and the Copper T 380Ag Intrauterine Devices: a Five-year Randomized Study." Contraception, vol. 42, no. 4, 1990, pp. 361-78.
Sivin I, el Mahgoub S, McCarthy T, et al. Long-term contraception with the levonorgestrel 20 mcg/day (LNg 20) and the copper T 380Ag intrauterine devices: a five-year randomized study. Contraception. 1990;42(4):361-78.
Sivin, I., el Mahgoub, S., McCarthy, T., Mishell, D. R., Shoupe, D., Alvarez, F., Brache, V., Jimenez, E., Diaz, J., & Faundes, A. (1990). Long-term contraception with the levonorgestrel 20 mcg/day (LNg 20) and the copper T 380Ag intrauterine devices: a five-year randomized study. Contraception, 42(4), 361-78.
Sivin I, et al. Long-term Contraception With the Levonorgestrel 20 Mcg/day (LNg 20) and the Copper T 380Ag Intrauterine Devices: a Five-year Randomized Study. Contraception. 1990;42(4):361-78. PubMed PMID: 2124179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term contraception with the levonorgestrel 20 mcg/day (LNg 20) and the copper T 380Ag intrauterine devices: a five-year randomized study. A1 - Sivin,I, AU - el Mahgoub,S, AU - McCarthy,T, AU - Mishell,D R,Jr AU - Shoupe,D, AU - Alvarez,F, AU - Brache,V, AU - Jimenez,E, AU - Diaz,J, AU - Faundes,A, PY - 1990/10/1/pubmed PY - 2001/3/28/medline PY - 1990/10/1/entrez KW - Acceptor Characteristics KW - Acceptors KW - Amenorrhea KW - Behavior KW - Contraception KW - Contraception Continuation KW - Contraception Termination--indications KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Methods KW - Contraceptive Usage KW - Data Analysis KW - Data Collection KW - Demographic Factors KW - Diseases KW - Family Planning KW - Family Planning Programs KW - Fertility KW - Fertility Measurements KW - Insertion KW - Iud KW - Iud, Hormone Releasing KW - Levonorgestrel--administraction and dosage KW - Menstruation Disorders KW - Method Acceptability KW - Parity KW - Population KW - Population Dynamics KW - Pregnancy Rate KW - Psychosocial Factors KW - Research Methodology KW - Treatment SP - 361 EP - 78 JF - Contraception JO - Contraception VL - 42 IS - 4 N2 - An intrauterine device, releasing approximately 20 micrograms/day of levonorgestrel (LNg 20), used by 1124 women, was studied in a randomized trial of five years duration in comparison with the Copper T, model TCu 380Agm in 1121 women. At five years, the gross cumulative pregnancy rate of 1.1 +/- 0.5 per 100 among users of the LNg 20 devices was not significantly different from the rate of 1.4 +/- 0.4 per 100 experienced by users of the Copper T 380Ag. The steroid-releasing IUD had significantly higher termination rates for expulsion and amenorrhea, a significantly lower termination rate for other menstrual problems and pain, and a lower continuation rate. The five-year continuation rate among women using the TCu 380Ag was 40.6 per 100 as compared with that of 33.0 per 100 among women randomized to the LNg 20 device (P less than .001). Terminations attributed to amenorrhea with the LNg device primarily account for differences in continuation. These two intrauterine devices are the most effective long-term, reversible IUDs yet reported in the literature. No other contraceptive methods have exhibited such low long-term pregnancy rates in randomized comparative trials. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/2124179/Long_term_contraception_with_the_levonorgestrel_20_mcg/day__LNg_20__and_the_copper_T_380Ag_intrauterine_devices:_a_five_year_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(90)90046-X DB - PRIME DP - Unbound Medicine ER -