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Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.
Psychopharmacology (Berl) 2011; 215(3):505-12P

Abstract

RATIONALE

The interaction between two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabigerol (CBG), which have been reported to act as a 5-hydroxytryptamine 1A (5-HT(1A)) agonist and antagonist, respectively, was evaluated.

OBJECTIVE

To evaluate the potential of CBG to reverse the anti-nausea, anti-emetic effects of CBD.

MATERIALS AND METHODS

In experiment 1, rats were pre-treated with CBG (0.0, 1, 5, and 10 mg/kg, ip), 15 min prior to being treated with CBD (experiment 1a: VEH or 5 mg/kg, ip) or 8-OH-DPAT (experiment 1b: VEH or 0.01 mg/kg, ip). Thirty minutes later, all rats received a pairing of 0.1% saccharin solution and LiCl (20 ml/kg of 0.15 M, ip). Seventy-two hours later, the rats received a drug-free taste reactivity test with saccharin to evaluate the effects of the treatments on the establishment of conditioned gaping reactions (a model of nausea). As well, conditioned saccharin avoidance was measured. In experiment 2, Suncus murinus were injected with CBG (5 mg/kg, ip) or VEH 15 min prior to CBD (5 mg/kg) or VEH and 30 min later were injected with LiCl (60 ml/kg of 0.15 M, i.p.), and the number of vomiting episodes were measured.

RESULTS

CBD (5 mg/kg) suppressed conditioned gaping in rats and vomiting in shrews, which were reversed by pre-treatment with all doses of CBG. CBG also prevented the anti-nausea effects of 8-OH-DPAT.

CONCLUSIONS

Interactions between moderate doses of CBG and CBD may oppose one another at the 5-HT(1A) receptor in the regulation of nausea and vomiting.

Authors+Show Affiliations

Department of Psychology, University of Guelph, Guelph, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21243485

Citation

Rock, Erin M., et al. "Interaction Between Non-psychotropic Cannabinoids in Marihuana: Effect of Cannabigerol (CBG) On the Anti-nausea or Anti-emetic Effects of Cannabidiol (CBD) in Rats and Shrews." Psychopharmacology, vol. 215, no. 3, 2011, pp. 505-12.
Rock EM, Goodwin JM, Limebeer CL, et al. Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. Psychopharmacology (Berl). 2011;215(3):505-12.
Rock, E. M., Goodwin, J. M., Limebeer, C. L., Breuer, A., Pertwee, R. G., Mechoulam, R., & Parker, L. A. (2011). Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. Psychopharmacology, 215(3), pp. 505-12. doi:10.1007/s00213-010-2157-4.
Rock EM, et al. Interaction Between Non-psychotropic Cannabinoids in Marihuana: Effect of Cannabigerol (CBG) On the Anti-nausea or Anti-emetic Effects of Cannabidiol (CBD) in Rats and Shrews. Psychopharmacology (Berl). 2011;215(3):505-12. PubMed PMID: 21243485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. AU - Rock,Erin M, AU - Goodwin,Jennifer M, AU - Limebeer,Cheryl L, AU - Breuer,Aviva, AU - Pertwee,Roger G, AU - Mechoulam,Raphael, AU - Parker,Linda A, Y1 - 2011/01/18/ PY - 2010/06/21/received PY - 2010/12/19/accepted PY - 2011/1/19/entrez PY - 2011/1/19/pubmed PY - 2011/9/2/medline SP - 505 EP - 12 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 215 IS - 3 N2 - RATIONALE: The interaction between two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabigerol (CBG), which have been reported to act as a 5-hydroxytryptamine 1A (5-HT(1A)) agonist and antagonist, respectively, was evaluated. OBJECTIVE: To evaluate the potential of CBG to reverse the anti-nausea, anti-emetic effects of CBD. MATERIALS AND METHODS: In experiment 1, rats were pre-treated with CBG (0.0, 1, 5, and 10 mg/kg, ip), 15 min prior to being treated with CBD (experiment 1a: VEH or 5 mg/kg, ip) or 8-OH-DPAT (experiment 1b: VEH or 0.01 mg/kg, ip). Thirty minutes later, all rats received a pairing of 0.1% saccharin solution and LiCl (20 ml/kg of 0.15 M, ip). Seventy-two hours later, the rats received a drug-free taste reactivity test with saccharin to evaluate the effects of the treatments on the establishment of conditioned gaping reactions (a model of nausea). As well, conditioned saccharin avoidance was measured. In experiment 2, Suncus murinus were injected with CBG (5 mg/kg, ip) or VEH 15 min prior to CBD (5 mg/kg) or VEH and 30 min later were injected with LiCl (60 ml/kg of 0.15 M, i.p.), and the number of vomiting episodes were measured. RESULTS: CBD (5 mg/kg) suppressed conditioned gaping in rats and vomiting in shrews, which were reversed by pre-treatment with all doses of CBG. CBG also prevented the anti-nausea effects of 8-OH-DPAT. CONCLUSIONS: Interactions between moderate doses of CBG and CBD may oppose one another at the 5-HT(1A) receptor in the regulation of nausea and vomiting. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/21243485/Interaction_between_non_psychotropic_cannabinoids_in_marihuana:_effect_of_cannabigerol__CBG__on_the_anti_nausea_or_anti_emetic_effects_of_cannabidiol__CBD__in_rats_and_shrews_ L2 - https://dx.doi.org/10.1007/s00213-010-2157-4 DB - PRIME DP - Unbound Medicine ER -