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Olfactory event-related potential in patients with rhinosinusitis-induced olfactory dysfunction.
Am J Rhinol Allergy. 2010 Sep-Oct; 24(5):330-5.AJ

Abstract

BACKGROUND

Olfactory disorders are a common syndrome in the rhinology clinic. Olfactory event-related potential (OERP) has been considered as an important alternative method to evaluate olfactory function. The aim of this study was to find the consistency of OERP and the psychophysics olfactory test (T&T olfactometry assessment) in rhinosinusitis patients with or without nasal polyposis.

METHODS

Both the psychophysics olfactory test and the OERP were performed in all patients before functional endoscopic sinus surgery (FESS). Detailed information including demographic, comorbidity, subjective symptoms, CT, and endoscopic examination were recorded. Six months later, the T&T test and OERP were reexamined in patients with preoperative identified OERP.

RESULTS

Preoperative OERP was identified in 26 patients of the nonpolyp group and 12 patients of the polyp group. Good correlation existed between T&T scores and amplitude and latency of N1 and P2 in 26 nonpolyp patients (p < 0.05). No meaningful correlation was apparent in 12 polyp patients (p > 0.05). Significant correlation existed in 7 polyp patients with a free olfactory cleft (OC) according to CT (p < 0.05). The other 5 patients with partial OC obstruction were anosmic according to the psychophysics olfactory test; however, OERP was present. Six months later, T&T scores decreased significantly only in these five patients (p < 0.05). Significant correlation was obtained between postoperative T&T scores and OERP in both polyp and nonpolyp groups (p < 0.05).

CONCLUSION

OERP can be used to investigate olfactory function of rhinosinusitis patients. Nasal polyp obstruction in specific parts of the OC might influence the consistency between the psychophysics olfactory test and OERP.

Authors+Show Affiliations

Department of Otolaryngology, Beijing Tongren Hospital, Capital Medical University, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21244732

Citation

Hu, Bin, et al. "Olfactory Event-related Potential in Patients With Rhinosinusitis-induced Olfactory Dysfunction." American Journal of Rhinology & Allergy, vol. 24, no. 5, 2010, pp. 330-5.
Hu B, Han D, Zhang L, et al. Olfactory event-related potential in patients with rhinosinusitis-induced olfactory dysfunction. Am J Rhinol Allergy. 2010;24(5):330-5.
Hu, B., Han, D., Zhang, L., Li, Y., Zang, H., Wang, T., Xian, M., Zhang, W., Yang, L., Wang, H., & He, F. (2010). Olfactory event-related potential in patients with rhinosinusitis-induced olfactory dysfunction. American Journal of Rhinology & Allergy, 24(5), 330-5. https://doi.org/10.2500/ajra.2010.24.3517
Hu B, et al. Olfactory Event-related Potential in Patients With Rhinosinusitis-induced Olfactory Dysfunction. Am J Rhinol Allergy. 2010 Sep-Oct;24(5):330-5. PubMed PMID: 21244732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory event-related potential in patients with rhinosinusitis-induced olfactory dysfunction. AU - Hu,Bin, AU - Han,Demin, AU - Zhang,Luo, AU - Li,Yunchuan, AU - Zang,Hongrui, AU - Wang,Tong, AU - Xian,Mu, AU - Zhang,Wei, AU - Yang,Ling, AU - Wang,Hong, AU - He,Fei, PY - 2011/1/20/entrez PY - 2011/1/20/pubmed PY - 2011/4/26/medline SP - 330 EP - 5 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 24 IS - 5 N2 - BACKGROUND: Olfactory disorders are a common syndrome in the rhinology clinic. Olfactory event-related potential (OERP) has been considered as an important alternative method to evaluate olfactory function. The aim of this study was to find the consistency of OERP and the psychophysics olfactory test (T&T olfactometry assessment) in rhinosinusitis patients with or without nasal polyposis. METHODS: Both the psychophysics olfactory test and the OERP were performed in all patients before functional endoscopic sinus surgery (FESS). Detailed information including demographic, comorbidity, subjective symptoms, CT, and endoscopic examination were recorded. Six months later, the T&T test and OERP were reexamined in patients with preoperative identified OERP. RESULTS: Preoperative OERP was identified in 26 patients of the nonpolyp group and 12 patients of the polyp group. Good correlation existed between T&T scores and amplitude and latency of N1 and P2 in 26 nonpolyp patients (p < 0.05). No meaningful correlation was apparent in 12 polyp patients (p > 0.05). Significant correlation existed in 7 polyp patients with a free olfactory cleft (OC) according to CT (p < 0.05). The other 5 patients with partial OC obstruction were anosmic according to the psychophysics olfactory test; however, OERP was present. Six months later, T&T scores decreased significantly only in these five patients (p < 0.05). Significant correlation was obtained between postoperative T&T scores and OERP in both polyp and nonpolyp groups (p < 0.05). CONCLUSION: OERP can be used to investigate olfactory function of rhinosinusitis patients. Nasal polyp obstruction in specific parts of the OC might influence the consistency between the psychophysics olfactory test and OERP. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/21244732/Olfactory_event_related_potential_in_patients_with_rhinosinusitis_induced_olfactory_dysfunction_ L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2010.24.3517?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -