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Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice.
Eur J Pharmacol. 2011 Mar 11; 654(3):304-14.EJ

Abstract

To investigate the abnormal function of T and B lymphocytes involved in collagen-induced arthritis in DBA/1 mice and the regulation role of TACI-Ig on T and B lymphocytes, collagen-induced arthritis models were established in DBA/1 mice. Mice were divided randomly into eight groups, including normal, collagen-induced arthritis model, TACI-Ig (0.350, 1.105, 3.333, 10, and 30 mg/kg) and IgG-Fc (10mg/kg) treated groups. The effect of TACI-Ig on collagen-induced arthritis was evaluated by arthritis scores, joints and spleens histopathology, paws radiology, and indices of thymus and spleen. T and B lymphocyte proliferations were assayed by [(3)H]-TdR method. B lymphocyte stimulator and prostaglandin E(2) in serum were assayed by enzyme linked immunosorbent assay. The subsets of T and B lymphocytes were assayed by flow cytometry. Results showed that the onset of paw-swelling was on day 31 after immunization. The peak of inflammation appeared on day 42 and then declined after day 63. Compared with normal mice, collagen-induced arthritis mice have increased arthritis scores, spleen and thymus indices, radiograph scores of joints, and pathology scores of joints and spleens. TACI-Ig could ameliorate these changes and reduce the increased serum level of B lymphocyte stimulator and prostaglandin E(2). Further studies showed that TACI-Ig inhibited T and B lymphocyte proliferation response, and inhibited differentiation and activity of T and B lymphocytes in collagen-induced arthritis mice. In conclusion, TACI-Ig has a good therapeutic action on collagen-induced arthritis mice, which might be related to the regulation of TACI-Ig on inflammation mediators and abnormal function of T and B lymphocytes.

Authors+Show Affiliations

Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology of Education Ministry of China, 230032 Hefei, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21244850

Citation

Liu, Yunjie, et al. "Therapeutic Effects of TACI-Ig On Collagen-induced Arthritis By Regulating T and B Lymphocytes Function in DBA/1 Mice." European Journal of Pharmacology, vol. 654, no. 3, 2011, pp. 304-14.
Liu Y, Zhang L, Wu Y, et al. Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice. Eur J Pharmacol. 2011;654(3):304-14.
Liu, Y., Zhang, L., Wu, Y., Tong, T., Zhao, W., Li, P., Huang, M., Wang, W., Fang, J., & Wei, W. (2011). Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice. European Journal of Pharmacology, 654(3), 304-14. https://doi.org/10.1016/j.ejphar.2011.01.002
Liu Y, et al. Therapeutic Effects of TACI-Ig On Collagen-induced Arthritis By Regulating T and B Lymphocytes Function in DBA/1 Mice. Eur J Pharmacol. 2011 Mar 11;654(3):304-14. PubMed PMID: 21244850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of TACI-Ig on collagen-induced arthritis by regulating T and B lymphocytes function in DBA/1 mice. AU - Liu,Yunjie, AU - Zhang,Lingling, AU - Wu,Yingqi, AU - Tong,Tong, AU - Zhao,Wendi, AU - Li,Peipei, AU - Huang,Min, AU - Wang,Wenxiang, AU - Fang,Jianmin, AU - Wei,Wei, Y1 - 2011/01/16/ PY - 2010/08/07/received PY - 2010/11/13/revised PY - 2011/01/04/accepted PY - 2011/1/20/entrez PY - 2011/1/20/pubmed PY - 2011/6/1/medline SP - 304 EP - 14 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 654 IS - 3 N2 - To investigate the abnormal function of T and B lymphocytes involved in collagen-induced arthritis in DBA/1 mice and the regulation role of TACI-Ig on T and B lymphocytes, collagen-induced arthritis models were established in DBA/1 mice. Mice were divided randomly into eight groups, including normal, collagen-induced arthritis model, TACI-Ig (0.350, 1.105, 3.333, 10, and 30 mg/kg) and IgG-Fc (10mg/kg) treated groups. The effect of TACI-Ig on collagen-induced arthritis was evaluated by arthritis scores, joints and spleens histopathology, paws radiology, and indices of thymus and spleen. T and B lymphocyte proliferations were assayed by [(3)H]-TdR method. B lymphocyte stimulator and prostaglandin E(2) in serum were assayed by enzyme linked immunosorbent assay. The subsets of T and B lymphocytes were assayed by flow cytometry. Results showed that the onset of paw-swelling was on day 31 after immunization. The peak of inflammation appeared on day 42 and then declined after day 63. Compared with normal mice, collagen-induced arthritis mice have increased arthritis scores, spleen and thymus indices, radiograph scores of joints, and pathology scores of joints and spleens. TACI-Ig could ameliorate these changes and reduce the increased serum level of B lymphocyte stimulator and prostaglandin E(2). Further studies showed that TACI-Ig inhibited T and B lymphocyte proliferation response, and inhibited differentiation and activity of T and B lymphocytes in collagen-induced arthritis mice. In conclusion, TACI-Ig has a good therapeutic action on collagen-induced arthritis mice, which might be related to the regulation of TACI-Ig on inflammation mediators and abnormal function of T and B lymphocytes. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21244850/Therapeutic_effects_of_TACI_Ig_on_collagen_induced_arthritis_by_regulating_T_and_B_lymphocytes_function_in_DBA/1_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)00018-5 DB - PRIME DP - Unbound Medicine ER -