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Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).
Ann Oncol 2011; 22(6):1420-6AO

Abstract

BACKGROUND

Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco.

MATERIALS AND METHODS

We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11,338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates.

RESULTS

Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipe-only smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3).

CONCLUSION

This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use.

Authors+Show Affiliations

Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21245160

Citation

Bertuccio, P, et al. "Cigar and Pipe Smoking, Smokeless Tobacco Use and Pancreatic Cancer: an Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4)." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 22, no. 6, 2011, pp. 1420-6.
Bertuccio P, La Vecchia C, Silverman DT, et al. Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2011;22(6):1420-6.
Bertuccio, P., La Vecchia, C., Silverman, D. T., Petersen, G. M., Bracci, P. M., Negri, E., ... Boffetta, P. (2011). Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). Annals of Oncology : Official Journal of the European Society for Medical Oncology, 22(6), pp. 1420-6. doi:10.1093/annonc/mdq613.
Bertuccio P, et al. Cigar and Pipe Smoking, Smokeless Tobacco Use and Pancreatic Cancer: an Analysis From the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2011;22(6):1420-6. PubMed PMID: 21245160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4). AU - Bertuccio,P, AU - La Vecchia,C, AU - Silverman,D T, AU - Petersen,G M, AU - Bracci,P M, AU - Negri,E, AU - Li,D, AU - Risch,H A, AU - Olson,S H, AU - Gallinger,S, AU - Miller,A B, AU - Bueno-de-Mesquita,H B, AU - Talamini,R, AU - Polesel,J, AU - Ghadirian,P, AU - Baghurst,P A, AU - Zatonski,W, AU - Fontham,E T, AU - Bamlet,W R, AU - Holly,E A, AU - Lucenteforte,E, AU - Hassan,M, AU - Yu,H, AU - Kurtz,R C, AU - Cotterchio,M, AU - Su,J, AU - Maisonneuve,P, AU - Duell,E J, AU - Bosetti,C, AU - Boffetta,P, Y1 - 2011/01/18/ PY - 2011/1/20/entrez PY - 2011/1/20/pubmed PY - 2011/12/13/medline SP - 1420 EP - 6 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 22 IS - 6 N2 - BACKGROUND: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. MATERIALS AND METHODS: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11,338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. RESULTS: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipe-only smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for ≥ 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). CONCLUSION: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21245160/Cigar_and_pipe_smoking_smokeless_tobacco_use_and_pancreatic_cancer:_an_analysis_from_the_International_Pancreatic_Cancer_Case_Control_Consortium__PanC4__ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdq613 DB - PRIME DP - Unbound Medicine ER -