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Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study.
Gynecol Endocrinol 2011; 27(10):789-93GE

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) are at a high risk to develop Gestational Diabetes mellitus (GDM). We hypothesized that metformin due to its metabolic, endocrine, vascular, and anti-inflammatory effects may reduce the incidence of GDM in PCOS women.

PATIENT AND METHOD

We carried out a prospective cohort study to determine the beneficial effects of metformin on PCOS patients during pregnancy. Three-hundred and sixty non-diabetic PCOS patients were included who were conceived on metformin by different treatment modalities. Two-hundred pregnant women continued on metformin at a dose of 1000-2000 mg daily throughout pregnancy (study group) and 160 women discontinued metformin use at the time of conception (control group).

RESULTS

There is a statistically significant reduction in the incidence of GDM in favor of metformin group (OR: 0.17, 95% CI: 0.07-0.37). There is a statistically significant reduction in the incidence of pre-eclampsia in favor of metformin group (OR: 0.35, 95% CI: 0.13-0.94).

CONCLUSION

Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women.

Authors+Show Affiliations

Egyptian International fertility & IVF Center, Miser International Hospital, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21247239

Citation

Khattab, S, et al. "Can Metformin Reduce the Incidence of Gestational Diabetes Mellitus in Pregnant Women With Polycystic Ovary Syndrome? Prospective Cohort Study." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 27, no. 10, 2011, pp. 789-93.
Khattab S, Mohsen IA, Aboul Foutouh I, et al. Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. Gynecol Endocrinol. 2011;27(10):789-93.
Khattab, S., Mohsen, I. A., Aboul Foutouh, I., Ashmawi, H. S., Mohsen, M. N., van Wely, M., ... Youssef, M. A. (2011). Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 27(10), pp. 789-93. doi:10.3109/09513590.2010.540600.
Khattab S, et al. Can Metformin Reduce the Incidence of Gestational Diabetes Mellitus in Pregnant Women With Polycystic Ovary Syndrome? Prospective Cohort Study. Gynecol Endocrinol. 2011;27(10):789-93. PubMed PMID: 21247239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. AU - Khattab,S, AU - Mohsen,I A, AU - Aboul Foutouh,I, AU - Ashmawi,H S, AU - Mohsen,M N, AU - van Wely,M, AU - van der Veen,F, AU - Youssef,M Af, Y1 - 2011/01/19/ PY - 2011/1/21/entrez PY - 2011/1/21/pubmed PY - 2012/3/1/medline SP - 789 EP - 93 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 27 IS - 10 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) are at a high risk to develop Gestational Diabetes mellitus (GDM). We hypothesized that metformin due to its metabolic, endocrine, vascular, and anti-inflammatory effects may reduce the incidence of GDM in PCOS women. PATIENT AND METHOD: We carried out a prospective cohort study to determine the beneficial effects of metformin on PCOS patients during pregnancy. Three-hundred and sixty non-diabetic PCOS patients were included who were conceived on metformin by different treatment modalities. Two-hundred pregnant women continued on metformin at a dose of 1000-2000 mg daily throughout pregnancy (study group) and 160 women discontinued metformin use at the time of conception (control group). RESULTS: There is a statistically significant reduction in the incidence of GDM in favor of metformin group (OR: 0.17, 95% CI: 0.07-0.37). There is a statistically significant reduction in the incidence of pre-eclampsia in favor of metformin group (OR: 0.35, 95% CI: 0.13-0.94). CONCLUSION: Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/21247239/Can_metformin_reduce_the_incidence_of_gestational_diabetes_mellitus_in_pregnant_women_with_polycystic_ovary_syndrome_Prospective_cohort_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2010.540600 DB - PRIME DP - Unbound Medicine ER -