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SAPHO syndrome presenting as widespread bony metastatic disease of unknown origin.
Rheumatol Int 2012; 32(2):505-7RI

Abstract

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome represents an inflammatory spectrum ranging from an osteitis through to a spondyloarthropathy which may or may not be associated with dermatological manifestations. We present the case of a 52-year-old female who presented with non-specific back pain. Radiological imaging showed mixed lytic and sclerotic lesions of her lumbar spine and pelvis consistent with bony metastatic disease. She underwent CT-guided biopsy that confirmed histological findings in keeping with non-bacterial osteitis/chronic recurrent multifocal osteomyelitis. This case report and review of the literature highlights the importance of the SAPHO syndrome and its treatment.

Authors+Show Affiliations

London Sarcoma Service, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21249499

Citation

Mann, Bhupinder, et al. "SAPHO Syndrome Presenting as Widespread Bony Metastatic Disease of Unknown Origin." Rheumatology International, vol. 32, no. 2, 2012, pp. 505-7.
Mann B, Shaerf DA, Sheeraz A, et al. SAPHO syndrome presenting as widespread bony metastatic disease of unknown origin. Rheumatol Int. 2012;32(2):505-7.
Mann, B., Shaerf, D. A., Sheeraz, A., Skinner, J. A., & Saifuddin, A. (2012). SAPHO syndrome presenting as widespread bony metastatic disease of unknown origin. Rheumatology International, 32(2), pp. 505-7. doi:10.1007/s00296-010-1742-5.
Mann B, et al. SAPHO Syndrome Presenting as Widespread Bony Metastatic Disease of Unknown Origin. Rheumatol Int. 2012;32(2):505-7. PubMed PMID: 21249499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SAPHO syndrome presenting as widespread bony metastatic disease of unknown origin. AU - Mann,Bhupinder, AU - Shaerf,Daniel A, AU - Sheeraz,Ahsan, AU - Skinner,John A, AU - Saifuddin,Asif, Y1 - 2011/01/20/ PY - 2010/08/10/received PY - 2010/12/30/accepted PY - 2011/1/21/entrez PY - 2011/1/21/pubmed PY - 2012/10/16/medline SP - 505 EP - 7 JF - Rheumatology international JO - Rheumatol. Int. VL - 32 IS - 2 N2 - SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome represents an inflammatory spectrum ranging from an osteitis through to a spondyloarthropathy which may or may not be associated with dermatological manifestations. We present the case of a 52-year-old female who presented with non-specific back pain. Radiological imaging showed mixed lytic and sclerotic lesions of her lumbar spine and pelvis consistent with bony metastatic disease. She underwent CT-guided biopsy that confirmed histological findings in keeping with non-bacterial osteitis/chronic recurrent multifocal osteomyelitis. This case report and review of the literature highlights the importance of the SAPHO syndrome and its treatment. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/21249499/SAPHO_syndrome_presenting_as_widespread_bony_metastatic_disease_of_unknown_origin_ L2 - https://dx.doi.org/10.1007/s00296-010-1742-5 DB - PRIME DP - Unbound Medicine ER -