Tags

Type your tag names separated by a space and hit enter

Effectiveness of pandemic and seasonal influenza vaccine in preventing pandemic influenza A(H1N1)2009 infection in England and Scotland 2009-2010.
Euro Surveill. 2011 Jan 13; 16(2)ES

Abstract

Following the global spread of pandemic influenza A(H1N1)2009, several pandemic vaccines have been rapidly developed. The United Kingdom and many other countries in the northern hemisphere implemented seasonal and pandemic influenza vaccine programmes in October 2009. We present the results of a case–control study to estimate effectiveness of such vaccines in preventing confirmed pandemic influenza infection. Some 5,982 individuals with influenza-like illness seen in general practices between November 2009 and January 2010 were enrolled. Those testing positive on PCR for pandemic influenza were assigned as cases and those testing negative as controls. Vaccine effectiveness was estimated as the relative reduction in odds of confirmed infection between vaccinated and unvaccinated individuals. Fourteen or more days after immunisation with the pandemic vaccine, adjusted vaccine effectiveness (VE) was 72% (95% confidence interval (CI): 21% to 90%). If protection was assumed to start after seven or more days, the adjusted VE was 71% (95% CI: 37% to 87%). Pandemic influenza vaccine was highly effective in preventing confirmed infection with pandemic influenza A(H1N1)2009 from one week after vaccination. No evidence of effectiveness against pandemic influenza A(H1N1)2009 was found for the 2009/10 trivalent seasonal influenza vaccine (adjusted VE of -30% (95% CI: -89% to 11%)).

Authors+Show Affiliations

Health Protection Agency Centre for Infections, London, United Kingdom. pia.hardelid@hpa.org.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21251487

Citation

Hardelid, P, et al. "Effectiveness of Pandemic and Seasonal Influenza Vaccine in Preventing Pandemic Influenza A(H1N1)2009 Infection in England and Scotland 2009-2010." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 16, no. 2, 2011.
Hardelid P, Fleming DM, McMenamin J, et al. Effectiveness of pandemic and seasonal influenza vaccine in preventing pandemic influenza A(H1N1)2009 infection in England and Scotland 2009-2010. Euro Surveill. 2011;16(2).
Hardelid, P., Fleming, D. M., McMenamin, J., Andrews, N., Robertson, C., SebastianPillai, P., Ellis, J., Carman, W., Wreghitt, T., Watson, J. M., & Pebody, R. G. (2011). Effectiveness of pandemic and seasonal influenza vaccine in preventing pandemic influenza A(H1N1)2009 infection in England and Scotland 2009-2010. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 16(2).
Hardelid P, et al. Effectiveness of Pandemic and Seasonal Influenza Vaccine in Preventing Pandemic Influenza A(H1N1)2009 Infection in England and Scotland 2009-2010. Euro Surveill. 2011 Jan 13;16(2) PubMed PMID: 21251487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of pandemic and seasonal influenza vaccine in preventing pandemic influenza A(H1N1)2009 infection in England and Scotland 2009-2010. AU - Hardelid,P, AU - Fleming,D M, AU - McMenamin,J, AU - Andrews,N, AU - Robertson,C, AU - SebastianPillai,P, AU - Ellis,J, AU - Carman,W, AU - Wreghitt,T, AU - Watson,J M, AU - Pebody,R G, Y1 - 2011/01/13/ PY - 2011/1/22/entrez PY - 2011/1/22/pubmed PY - 2011/3/19/medline JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 16 IS - 2 N2 - Following the global spread of pandemic influenza A(H1N1)2009, several pandemic vaccines have been rapidly developed. The United Kingdom and many other countries in the northern hemisphere implemented seasonal and pandemic influenza vaccine programmes in October 2009. We present the results of a case–control study to estimate effectiveness of such vaccines in preventing confirmed pandemic influenza infection. Some 5,982 individuals with influenza-like illness seen in general practices between November 2009 and January 2010 were enrolled. Those testing positive on PCR for pandemic influenza were assigned as cases and those testing negative as controls. Vaccine effectiveness was estimated as the relative reduction in odds of confirmed infection between vaccinated and unvaccinated individuals. Fourteen or more days after immunisation with the pandemic vaccine, adjusted vaccine effectiveness (VE) was 72% (95% confidence interval (CI): 21% to 90%). If protection was assumed to start after seven or more days, the adjusted VE was 71% (95% CI: 37% to 87%). Pandemic influenza vaccine was highly effective in preventing confirmed infection with pandemic influenza A(H1N1)2009 from one week after vaccination. No evidence of effectiveness against pandemic influenza A(H1N1)2009 was found for the 2009/10 trivalent seasonal influenza vaccine (adjusted VE of -30% (95% CI: -89% to 11%)). SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/21251487/Effectiveness_of_pandemic_and_seasonal_influenza_vaccine_in_preventing_pandemic_influenza_A_H1N1_2009_infection_in_England_and_Scotland_2009_2010_ L2 - http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19763 DB - PRIME DP - Unbound Medicine ER -