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Detection of Blastomyces dermatitidis antigen in patients with newly diagnosed blastomycosis.
Diagn Microbiol Infect Dis. 2011 Feb; 69(2):187-91.DM

Abstract

Blastomycosis is a serious and potentially fatal infection, and diagnosis can be difficult at times. We evaluated the diagnostic utility of a commercially available assay for detection of Blastomyces dermatitidis antigen, recently modified to permit quantitation, in subjects with newly diagnosed blastomycosis. Twenty-three of 27 (85.1%) subjects had detectable B. dermatitidis antigenuria. In 2 of these 23, positive results were obtained after concentration of the urine specimen. Nine of 11 (81.8%) subjects had detectable B. dermatitidis antigen in serum, including 3 subjects with negative results before treatment of serum with ethylenediaminetetraacetic acid (EDTA) and positive results after EDTA treatment. B. dermatitidis antigen was not detected in specimens from 50 control subjects but was detected in 15 patients with histoplasmosis. B. dermatitidis antigen was detected in most of the patients with blastomycosis and can be a useful tool for timely diagnosis.

Authors+Show Affiliations

Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. bariolajeremyr@uams.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21251563

Citation

Bariola, J Ryan, et al. "Detection of Blastomyces Dermatitidis Antigen in Patients With Newly Diagnosed Blastomycosis." Diagnostic Microbiology and Infectious Disease, vol. 69, no. 2, 2011, pp. 187-91.
Bariola JR, Hage CA, Durkin M, et al. Detection of Blastomyces dermatitidis antigen in patients with newly diagnosed blastomycosis. Diagn Microbiol Infect Dis. 2011;69(2):187-91.
Bariola, J. R., Hage, C. A., Durkin, M., Bensadoun, E., Gubbins, P. O., Wheat, L. J., & Bradsher, R. W. (2011). Detection of Blastomyces dermatitidis antigen in patients with newly diagnosed blastomycosis. Diagnostic Microbiology and Infectious Disease, 69(2), 187-91. https://doi.org/10.1016/j.diagmicrobio.2010.09.015
Bariola JR, et al. Detection of Blastomyces Dermatitidis Antigen in Patients With Newly Diagnosed Blastomycosis. Diagn Microbiol Infect Dis. 2011;69(2):187-91. PubMed PMID: 21251563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Blastomyces dermatitidis antigen in patients with newly diagnosed blastomycosis. AU - Bariola,J Ryan, AU - Hage,Chadi A, AU - Durkin,Michelle, AU - Bensadoun,Eric, AU - Gubbins,Paul O, AU - Wheat,L Joseph, AU - Bradsher,Robert W,Jr PY - 2010/06/04/received PY - 2010/09/10/revised PY - 2010/09/20/accepted PY - 2011/1/22/entrez PY - 2011/1/22/pubmed PY - 2011/11/8/medline SP - 187 EP - 91 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 69 IS - 2 N2 - Blastomycosis is a serious and potentially fatal infection, and diagnosis can be difficult at times. We evaluated the diagnostic utility of a commercially available assay for detection of Blastomyces dermatitidis antigen, recently modified to permit quantitation, in subjects with newly diagnosed blastomycosis. Twenty-three of 27 (85.1%) subjects had detectable B. dermatitidis antigenuria. In 2 of these 23, positive results were obtained after concentration of the urine specimen. Nine of 11 (81.8%) subjects had detectable B. dermatitidis antigen in serum, including 3 subjects with negative results before treatment of serum with ethylenediaminetetraacetic acid (EDTA) and positive results after EDTA treatment. B. dermatitidis antigen was not detected in specimens from 50 control subjects but was detected in 15 patients with histoplasmosis. B. dermatitidis antigen was detected in most of the patients with blastomycosis and can be a useful tool for timely diagnosis. SN - 1879-0070 UR - https://www.unboundmedicine.com/medline/citation/21251563/Detection_of_Blastomyces_dermatitidis_antigen_in_patients_with_newly_diagnosed_blastomycosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(10)00391-3 DB - PRIME DP - Unbound Medicine ER -