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False-positive amphetamine toxicology screen results in three pregnant women using labetalol.
Obstet Gynecol. 2011 Feb; 117(2 Pt 2):503-506.OG

Abstract

BACKGROUND

Labetalol is commonly used for control of hypertension in pregnancy. A component of the workup for new-onset hypertension in pregnancy often includes a urine drug screen. A labetalol metabolite is structurally similar to amphetamine and methamphetamine, thus causing potential cross-reactivity in drug immunoassays.

CASES

We present one case of cocaine-induced hypertensive crisis superimposed on chronic hypertension and two cases of severe preeclampsia for which patients required escalating doses of labetalol for hypertension, with subsequent false-positive amphetamine urine drug screen results.

CONCLUSION

In pregnant women requiring labetalol for treatment of hypertensive disease, a urine drug screen may be falsely positive for amphetamines and methamphetamines. Providers should be cognizant of this possibility when interpreting the results of urine drug screens.

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Authors+Show Affiliations

Yee LM
From the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California.
Wu D
No affiliation info available

MeSH

AdultAmphetamineAntihypertensive AgentsCesarean SectionChronic DiseaseCocaineCross ReactionsFalse Positive ReactionsFemaleGas Chromatography-Mass SpectrometryHumansHypertension, Pregnancy-InducedImmunoassayInfant, NewbornLabetalolNifedipinePregnancyPregnancy OutcomePulmonary EdemaStillbirthSubstance Abuse Detection

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21252805

Citation

Yee, Lynn M., and Danny Wu. "False-positive Amphetamine Toxicology Screen Results in Three Pregnant Women Using Labetalol." Obstetrics and Gynecology, vol. 117, no. 2 Pt 2, 2011, pp. 503-506.
Yee LM, Wu D. False-positive amphetamine toxicology screen results in three pregnant women using labetalol. Obstet Gynecol. 2011;117(2 Pt 2):503-506.
Yee, L. M., & Wu, D. (2011). False-positive amphetamine toxicology screen results in three pregnant women using labetalol. Obstetrics and Gynecology, 117(2 Pt 2), 503-506. https://doi.org/10.1097/AOG.0b013e318206c07c
Yee LM, Wu D. False-positive Amphetamine Toxicology Screen Results in Three Pregnant Women Using Labetalol. Obstet Gynecol. 2011;117(2 Pt 2):503-506. PubMed PMID: 21252805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - False-positive amphetamine toxicology screen results in three pregnant women using labetalol. AU - Yee,Lynn M, AU - Wu,Danny, PY - 2011/1/22/entrez PY - 2011/1/22/pubmed PY - 2011/3/5/medline SP - 503 EP - 506 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 117 IS - 2 Pt 2 N2 - BACKGROUND: Labetalol is commonly used for control of hypertension in pregnancy. A component of the workup for new-onset hypertension in pregnancy often includes a urine drug screen. A labetalol metabolite is structurally similar to amphetamine and methamphetamine, thus causing potential cross-reactivity in drug immunoassays. CASES: We present one case of cocaine-induced hypertensive crisis superimposed on chronic hypertension and two cases of severe preeclampsia for which patients required escalating doses of labetalol for hypertension, with subsequent false-positive amphetamine urine drug screen results. CONCLUSION: In pregnant women requiring labetalol for treatment of hypertensive disease, a urine drug screen may be falsely positive for amphetamines and methamphetamines. Providers should be cognizant of this possibility when interpreting the results of urine drug screens. SN - 1873-233X UR - https://www.unboundmedicine.com/medline/citation/21252805/False_positive_amphetamine_toxicology_screen_results_in_three_pregnant_women_using_labetalol_ L2 - https://doi.org/10.1097/AOG.0b013e318206c07c DB - PRIME DP - Unbound Medicine ER -