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Cyproterone acetate or drospirenone containing combined oral contraceptives plus spironolactone or cyproterone acetate for hirsutism: randomized comparison of three regimens.
J Dermatolog Treat. 2012 Jun; 23(3):177-83.JD

Abstract

OBJECTIVE

To compare the effectiveness of three different combinations of combined oral contraceptives (COCs) and anti-androgens in the treatment of hirsutism.

METHODS

A total of 134 women with moderate and severe hirsutism were randomly assigned to three treatment regimens: Group I received 30 μg of ethinyl estradiol (EE)/3 mg of drospirenone (DRSP) plus 100 mg of cyproterone acetate (CPA) (n = 45); group II received 30 μg of EE/3 mg of DRSP plus 100 mg of spironolactone (n = 44); and group III received 35 μg of EE/2 mg of CPA plus 100 mg of CPA (n = 45), daily for 6 months. The decrease in the modified Ferriman-Gallwey hirsutism score (mFGS) was the main outcome measure.

RESULTS

The mean decrease in mFGS after 3 and 6 months of the treatment course was 26% and 49% in group I (both p < 0.01), 27% and 49% in group II (both p < 0.01), and 25% and 45% in group III (both p < 0.01), respectively, when compared with baseline. Although the mFGS was significantly decreased in all groups, there was no significant difference between groups.

CONCLUSION

CPA or DRSP containing COCs in combination with CPA or spironolactone have similar effects for the treatment of hirsutism.

Authors+Show Affiliations

Dermatology Clinic, Numune Education and Research Hospital, Seyhan Practice Center, Adana, Turkey. drhandankelekci@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21254871

Citation

Kelekci, Kiymet Handan, et al. "Cyproterone Acetate or Drospirenone Containing Combined Oral Contraceptives Plus Spironolactone or Cyproterone Acetate for Hirsutism: Randomized Comparison of Three Regimens." The Journal of Dermatological Treatment, vol. 23, no. 3, 2012, pp. 177-83.
Kelekci KH, Kelekci S, Yengel I, et al. Cyproterone acetate or drospirenone containing combined oral contraceptives plus spironolactone or cyproterone acetate for hirsutism: randomized comparison of three regimens. J Dermatolog Treat. 2012;23(3):177-83.
Kelekci, K. H., Kelekci, S., Yengel, I., Gul, S., & Yilmaz, B. (2012). Cyproterone acetate or drospirenone containing combined oral contraceptives plus spironolactone or cyproterone acetate for hirsutism: randomized comparison of three regimens. The Journal of Dermatological Treatment, 23(3), 177-83. https://doi.org/10.3109/09546634.2010.519766
Kelekci KH, et al. Cyproterone Acetate or Drospirenone Containing Combined Oral Contraceptives Plus Spironolactone or Cyproterone Acetate for Hirsutism: Randomized Comparison of Three Regimens. J Dermatolog Treat. 2012;23(3):177-83. PubMed PMID: 21254871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyproterone acetate or drospirenone containing combined oral contraceptives plus spironolactone or cyproterone acetate for hirsutism: randomized comparison of three regimens. AU - Kelekci,Kiymet Handan, AU - Kelekci,Sefa, AU - Yengel,Irem, AU - Gul,Sule, AU - Yilmaz,Bulent, Y1 - 2011/01/22/ PY - 2011/1/25/entrez PY - 2011/1/25/pubmed PY - 2012/9/28/medline SP - 177 EP - 83 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 23 IS - 3 N2 - OBJECTIVE: To compare the effectiveness of three different combinations of combined oral contraceptives (COCs) and anti-androgens in the treatment of hirsutism. METHODS: A total of 134 women with moderate and severe hirsutism were randomly assigned to three treatment regimens: Group I received 30 μg of ethinyl estradiol (EE)/3 mg of drospirenone (DRSP) plus 100 mg of cyproterone acetate (CPA) (n = 45); group II received 30 μg of EE/3 mg of DRSP plus 100 mg of spironolactone (n = 44); and group III received 35 μg of EE/2 mg of CPA plus 100 mg of CPA (n = 45), daily for 6 months. The decrease in the modified Ferriman-Gallwey hirsutism score (mFGS) was the main outcome measure. RESULTS: The mean decrease in mFGS after 3 and 6 months of the treatment course was 26% and 49% in group I (both p < 0.01), 27% and 49% in group II (both p < 0.01), and 25% and 45% in group III (both p < 0.01), respectively, when compared with baseline. Although the mFGS was significantly decreased in all groups, there was no significant difference between groups. CONCLUSION: CPA or DRSP containing COCs in combination with CPA or spironolactone have similar effects for the treatment of hirsutism. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/21254871/Cyproterone_acetate_or_drospirenone_containing_combined_oral_contraceptives_plus_spironolactone_or_cyproterone_acetate_for_hirsutism:_randomized_comparison_of_three_regimens_ L2 - https://www.tandfonline.com/doi/full/10.3109/09546634.2010.519766 DB - PRIME DP - Unbound Medicine ER -