Tags

Type your tag names separated by a space and hit enter

Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children.
Pediatr Allergy Immunol. 2011 May; 22(3):320-6.PA

Abstract

The role of endotoxin and house dust mite allergen (HDM) in allergen sensitization and asthma is unclear. The timeframe of exposure and asthma assessment appears critical. We aimed to determine, in children at 7 yr of age, the association between current exposure to endotoxin and HDM and risks of recurrent wheeze, paediatric allergist diagnosed asthma and allergen sensitization. Three hundred and eighty children who had an increased risk of asthma because of family background were assessed at age 7 yr by a questionnaire-standardized interview, allergen skin testing and clinical examination by a paediatric allergist. Dust samples were collected from their homes and analysed for levels of endotoxin and HDM (Der p 1 and Der f 1). Levels of endotoxin in dust samples were associated with protection from paediatric allergist diagnosed asthma with inhaled steroid use (OR 0.69, 95% CI 0.53-0.91) and specific sensitization to dog allergen (OR 0.68, 95% CI 0.51-0.90) at the age of 7 yr; both endotoxin and HDM were associated with decreased risk of sensitization to dog allergen. In high-risk children at age 7, endotoxin levels were associated with decreased sensitization to dog, as well as with decreased asthma.

Authors+Show Affiliations

Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. chris.carlsten@vch.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21255084

Citation

Carlsten, Chris, et al. "Association Between Endotoxin and Mite Allergen Exposure With Asthma and Specific Sensitization at Age 7 in High-risk Children." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 22, no. 3, 2011, pp. 320-6.
Carlsten C, Ferguson A, Dimich-Ward H, et al. Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children. Pediatr Allergy Immunol. 2011;22(3):320-6.
Carlsten, C., Ferguson, A., Dimich-Ward, H., Chan, H., DyBuncio, A., Rousseau, R., Becker, A., & Chan-Yeung, M. (2011). Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 22(3), 320-6. https://doi.org/10.1111/j.1399-3038.2010.01123.x
Carlsten C, et al. Association Between Endotoxin and Mite Allergen Exposure With Asthma and Specific Sensitization at Age 7 in High-risk Children. Pediatr Allergy Immunol. 2011;22(3):320-6. PubMed PMID: 21255084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between endotoxin and mite allergen exposure with asthma and specific sensitization at age 7 in high-risk children. AU - Carlsten,Chris, AU - Ferguson,Alexander, AU - Dimich-Ward,Helen, AU - Chan,Henry, AU - DyBuncio,Anne, AU - Rousseau,Roxanne, AU - Becker,Allan, AU - Chan-Yeung,Moira, Y1 - 2011/01/23/ PY - 2011/1/25/entrez PY - 2011/1/25/pubmed PY - 2011/8/16/medline SP - 320 EP - 6 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 22 IS - 3 N2 - The role of endotoxin and house dust mite allergen (HDM) in allergen sensitization and asthma is unclear. The timeframe of exposure and asthma assessment appears critical. We aimed to determine, in children at 7 yr of age, the association between current exposure to endotoxin and HDM and risks of recurrent wheeze, paediatric allergist diagnosed asthma and allergen sensitization. Three hundred and eighty children who had an increased risk of asthma because of family background were assessed at age 7 yr by a questionnaire-standardized interview, allergen skin testing and clinical examination by a paediatric allergist. Dust samples were collected from their homes and analysed for levels of endotoxin and HDM (Der p 1 and Der f 1). Levels of endotoxin in dust samples were associated with protection from paediatric allergist diagnosed asthma with inhaled steroid use (OR 0.69, 95% CI 0.53-0.91) and specific sensitization to dog allergen (OR 0.68, 95% CI 0.51-0.90) at the age of 7 yr; both endotoxin and HDM were associated with decreased risk of sensitization to dog allergen. In high-risk children at age 7, endotoxin levels were associated with decreased sensitization to dog, as well as with decreased asthma. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/21255084/Association_between_endotoxin_and_mite_allergen_exposure_with_asthma_and_specific_sensitization_at_age_7_in_high_risk_children_ L2 - https://doi.org/10.1111/j.1399-3038.2010.01123.x DB - PRIME DP - Unbound Medicine ER -