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Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study.
Clin Exp Allergy. 2011 Mar; 41(3):407-16.CE

Abstract

BACKGROUND

Prevalence of atopic disorders has increased rapidly, but aetiological factors responsible for this increase are still largely unknown. Prenatal exposure to a pro-inflammatory fatty acid status is hypothesized although little research has been carried out.

OBJECTIVE

To investigate whether prenatal fatty acid exposures are associated with atopy in childhood.

METHODS

In the KOALA Birth Cohort Study, maternal blood samples (n=1275) at 34-36 weeks of pregnancy were assayed for n-6 and n-3 long-chain polyunsaturated fatty acids (LCPs). The full spectrum of offspring atopic manifestations (wheeze, asthma, allergic rhinoconjunctivitis, eczema, atopic dermatitis, allergic sensitization, and high total IgE) until the age of 6-7 years was assessed by repeated parental questionnaires and measurements of total and specific IgE. Associations of maternal fatty acid status with child atopic outcomes were analysed using multivariable logistic regression and generalized estimating equations for repeated measurements.

RESULTS

High ratio of maternal n-6 vs. n-3 LCPs was associated with a lower risk of eczema in the child (P for trend 0.012). More specifically, we found a decreased risk of eczema in the first 7 months of life with increasing arachidonic acid levels (P for trend 0.013). No associations were found between maternal fatty acids and offspring airway-related atopic manifestations, sensitization, or high total IgE.

CONCLUSION AND CLINICAL RELEVANCE

The development of atopic disorders in early childhood is associated with prenatal exposure to n-6 vs. n-3 fatty acids, but with inconsistencies between different manifestations. Further exploration of associations with maternal diet and genetic variants in genes regulating fatty acid metabolism are required. This study shows that the influence of prenatal exposure to fatty acids on the risk of eczema in the child is limited to the first year of life.

Authors+Show Affiliations

Department of Epidemiology, CAPHRI School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21255139

Citation

Notenboom, M L., et al. "Maternal Fatty Acid Status in Pregnancy and Childhood Atopic Manifestations: KOALA Birth Cohort Study." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 41, no. 3, 2011, pp. 407-16.
Notenboom ML, Mommers M, Jansen EH, et al. Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study. Clin Exp Allergy. 2011;41(3):407-16.
Notenboom, M. L., Mommers, M., Jansen, E. H., Penders, J., & Thijs, C. (2011). Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 41(3), 407-16. https://doi.org/10.1111/j.1365-2222.2010.03672.x
Notenboom ML, et al. Maternal Fatty Acid Status in Pregnancy and Childhood Atopic Manifestations: KOALA Birth Cohort Study. Clin Exp Allergy. 2011;41(3):407-16. PubMed PMID: 21255139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study. AU - Notenboom,M L, AU - Mommers,M, AU - Jansen,E H J M, AU - Penders,J, AU - Thijs,C, Y1 - 2011/01/24/ PY - 2011/1/25/entrez PY - 2011/1/25/pubmed PY - 2011/5/24/medline SP - 407 EP - 16 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 41 IS - 3 N2 - BACKGROUND: Prevalence of atopic disorders has increased rapidly, but aetiological factors responsible for this increase are still largely unknown. Prenatal exposure to a pro-inflammatory fatty acid status is hypothesized although little research has been carried out. OBJECTIVE: To investigate whether prenatal fatty acid exposures are associated with atopy in childhood. METHODS: In the KOALA Birth Cohort Study, maternal blood samples (n=1275) at 34-36 weeks of pregnancy were assayed for n-6 and n-3 long-chain polyunsaturated fatty acids (LCPs). The full spectrum of offspring atopic manifestations (wheeze, asthma, allergic rhinoconjunctivitis, eczema, atopic dermatitis, allergic sensitization, and high total IgE) until the age of 6-7 years was assessed by repeated parental questionnaires and measurements of total and specific IgE. Associations of maternal fatty acid status with child atopic outcomes were analysed using multivariable logistic regression and generalized estimating equations for repeated measurements. RESULTS: High ratio of maternal n-6 vs. n-3 LCPs was associated with a lower risk of eczema in the child (P for trend 0.012). More specifically, we found a decreased risk of eczema in the first 7 months of life with increasing arachidonic acid levels (P for trend 0.013). No associations were found between maternal fatty acids and offspring airway-related atopic manifestations, sensitization, or high total IgE. CONCLUSION AND CLINICAL RELEVANCE: The development of atopic disorders in early childhood is associated with prenatal exposure to n-6 vs. n-3 fatty acids, but with inconsistencies between different manifestations. Further exploration of associations with maternal diet and genetic variants in genes regulating fatty acid metabolism are required. This study shows that the influence of prenatal exposure to fatty acids on the risk of eczema in the child is limited to the first year of life. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/21255139/Maternal_fatty_acid_status_in_pregnancy_and_childhood_atopic_manifestations:_KOALA_Birth_Cohort_Study_ L2 - https://doi.org/10.1111/j.1365-2222.2010.03672.x DB - PRIME DP - Unbound Medicine ER -