Tags

Type your tag names separated by a space and hit enter

Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease.
Aging Cell. 2011 Jun; 10(3):368-82.AC

Abstract

Aquaporin-4 (AQP4) is highly expressed in mammalian brains and is involved in the pathophysiology of cerebral disorders, including stroke, tumors, infections, hydrocephalus, epilepsy, and traumatic brain injury. We found that AQP4-deficient mice were hypersensitive to stimulations such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or lipopolysaccharide compared to wild-type (WT) littermates. In a mouse model of MPTP-induced Parkinson's disease (PD), AQP4-deficient animals show more robust microglial inflammatory responses and more severe loss of dopaminergic neurons (DNs) compared with WT mice. However, a few studies have investigated the association of abnormal AQP4 levels with immune dysfunction. Here, for the first time, we report AQP4 expression in mouse thymus, spleen, and lymph nodes. Furthermore, the significantly lower numbers of CD4(+) CD25(+) regulatory T cells in AQP4-deficient mice compared to WT mice, perhaps resulting from impaired thymic generation, may be responsible for the uncontrolled microglial inflammatory responses and subsequent severe loss of DNs in the substantia nigra pars compacta in the MPTP-induced PD model. These novel findings suggest that AQP4 deficiency may disrupt immunosuppressive regulators, resulting in hyperactive immune responses and potentially contributing to the increased severity of PD or other immune-associated diseases.

Authors+Show Affiliations

Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21255222

Citation

Chi, Ying, et al. "Novel Role of Aquaporin-4 in CD4+ CD25+ T Regulatory Cell Development and Severity of Parkinson's Disease." Aging Cell, vol. 10, no. 3, 2011, pp. 368-82.
Chi Y, Fan Y, He L, et al. Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. Aging Cell. 2011;10(3):368-82.
Chi, Y., Fan, Y., He, L., Liu, W., Wen, X., Zhou, S., Wang, X., Zhang, C., Kong, H., Sonoda, L., Tripathi, P., Li, C. J., Yu, M. S., Su, C., & Hu, G. (2011). Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. Aging Cell, 10(3), 368-82. https://doi.org/10.1111/j.1474-9726.2011.00677.x
Chi Y, et al. Novel Role of Aquaporin-4 in CD4+ CD25+ T Regulatory Cell Development and Severity of Parkinson's Disease. Aging Cell. 2011;10(3):368-82. PubMed PMID: 21255222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. AU - Chi,Ying, AU - Fan,Yi, AU - He,Lei, AU - Liu,Wei, AU - Wen,Xiaoyun, AU - Zhou,Sha, AU - Wang,Xuefeng, AU - Zhang,Cui, AU - Kong,Hui, AU - Sonoda,Laura, AU - Tripathi,Prem, AU - Li,Carrie J, AU - Yu,Michelle S, AU - Su,Chuan, AU - Hu,Gang, Y1 - 2011/03/22/ PY - 2011/1/25/entrez PY - 2011/1/25/pubmed PY - 2011/9/14/medline SP - 368 EP - 82 JF - Aging cell JO - Aging Cell VL - 10 IS - 3 N2 - Aquaporin-4 (AQP4) is highly expressed in mammalian brains and is involved in the pathophysiology of cerebral disorders, including stroke, tumors, infections, hydrocephalus, epilepsy, and traumatic brain injury. We found that AQP4-deficient mice were hypersensitive to stimulations such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or lipopolysaccharide compared to wild-type (WT) littermates. In a mouse model of MPTP-induced Parkinson's disease (PD), AQP4-deficient animals show more robust microglial inflammatory responses and more severe loss of dopaminergic neurons (DNs) compared with WT mice. However, a few studies have investigated the association of abnormal AQP4 levels with immune dysfunction. Here, for the first time, we report AQP4 expression in mouse thymus, spleen, and lymph nodes. Furthermore, the significantly lower numbers of CD4(+) CD25(+) regulatory T cells in AQP4-deficient mice compared to WT mice, perhaps resulting from impaired thymic generation, may be responsible for the uncontrolled microglial inflammatory responses and subsequent severe loss of DNs in the substantia nigra pars compacta in the MPTP-induced PD model. These novel findings suggest that AQP4 deficiency may disrupt immunosuppressive regulators, resulting in hyperactive immune responses and potentially contributing to the increased severity of PD or other immune-associated diseases. SN - 1474-9726 UR - https://www.unboundmedicine.com/medline/citation/21255222/Novel_role_of_aquaporin_4_in_CD4+_CD25+_T_regulatory_cell_development_and_severity_of_Parkinson's_disease_ L2 - https://doi.org/10.1111/j.1474-9726.2011.00677.x DB - PRIME DP - Unbound Medicine ER -