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A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinyl estradiol and levonorgestrel on lipid and lipoprotein metabolism.
Contraception. 1990 Nov; 42(5):535-54.C

Abstract

A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinylestradiol (EE) and levonorgestrel (LNG) on lipid and lipoprotein metabolism was conducted on 45 Singapore women under the WHO Special Programme of Research in Human Reproduction. The women were randomly allocated to one of the two pill groups--a triphasic preparation containing low doses of LNG and EE in various proportions and a monophasic preparation of 150 micrograms LNG and 30 micrograms EE, and an additional 18 women, choosing to use IUDs, were recruited as controls. Blood samples were taken at admission, 3 and 12 months thereafter. For both pill groups, total cholesterol decreased with duration of use, while HDL cholesterol decreased slightly at 3 months and thereafter increased. LDL cholesterol decreased slightly at 3 months, returning to baseline at 12 months for the monophasic group, while remaining unchanged at 12 months for the triphasic group. The monophasic preparation appeared to lower total, LDL and HDL cholesterols to a greater extent at 3 months than the triphasic preparation. Compared with IUD users, for the monophasic group, both total and HDL cholesterols were significantly lower at 3 months and HDL and LDL cholesterols were lower at 12 months. In addition, ratios of HDL cholesterol/LDL cholesterol and HDL cholesterol/total cholesterol were significantly lower at 12 months. Changes in triglycerides were minimal for both pill groups. However, at 3 months, triglycerides for the triphasic group were significantly higher than the IUD users, but this observation was not of any clinical importance since comparison of changes with their respective pretreatment values were not statistically significant. These results indicate that these changes are related to the dosage and estrogen-progestogen ratio of the preparation. Furthermore, the monophasic preparation may have a disadvantage over the triphasic preparation since it appears to cause more disturbance in lipid metabolism. However, it is noted that these changes in lipids and lipoproteins were minimal and did not appear to be of any clinical significance.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, National University of Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2125546

Citation

Loke, D F., et al. "A Comparative Study of the Effects of a Monophasic and a Triphasic Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel On Lipid and Lipoprotein Metabolism." Contraception, vol. 42, no. 5, 1990, pp. 535-54.
Loke DF, Ng CS, Samsioe G, et al. A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinyl estradiol and levonorgestrel on lipid and lipoprotein metabolism. Contraception. 1990;42(5):535-54.
Loke, D. F., Ng, C. S., Samsioe, G., Holck, S., & Ratnam, S. S. (1990). A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinyl estradiol and levonorgestrel on lipid and lipoprotein metabolism. Contraception, 42(5), 535-54.
Loke DF, et al. A Comparative Study of the Effects of a Monophasic and a Triphasic Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel On Lipid and Lipoprotein Metabolism. Contraception. 1990;42(5):535-54. PubMed PMID: 2125546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinyl estradiol and levonorgestrel on lipid and lipoprotein metabolism. AU - Loke,D F, AU - Ng,C S, AU - Samsioe,G, AU - Holck,S, AU - Ratnam,S S, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez KW - Asia KW - Biology KW - Cholesterol KW - Comparative Studies KW - Contraception KW - Contraceptive Agents, Estrogen--administraction and dosage KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Methods KW - Developing Countries KW - Ethinyl Estradiol--administraction and dosage KW - Examinations And Diagnoses KW - Family Planning KW - Laboratory Examinations And Diagnoses KW - Levonorgestrel--administraction and dosage KW - Lipid Metabolic Effects--analysis KW - Lipid Metabolic Effects--changes KW - Lipids KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Phasic KW - Physiology KW - Research Methodology KW - Singapore KW - Southeastern Asia KW - Studies KW - Treatment SP - 535 EP - 54 JF - Contraception JO - Contraception VL - 42 IS - 5 N2 - A comparative study of the effects of a monophasic and a triphasic oral contraceptive containing ethinylestradiol (EE) and levonorgestrel (LNG) on lipid and lipoprotein metabolism was conducted on 45 Singapore women under the WHO Special Programme of Research in Human Reproduction. The women were randomly allocated to one of the two pill groups--a triphasic preparation containing low doses of LNG and EE in various proportions and a monophasic preparation of 150 micrograms LNG and 30 micrograms EE, and an additional 18 women, choosing to use IUDs, were recruited as controls. Blood samples were taken at admission, 3 and 12 months thereafter. For both pill groups, total cholesterol decreased with duration of use, while HDL cholesterol decreased slightly at 3 months and thereafter increased. LDL cholesterol decreased slightly at 3 months, returning to baseline at 12 months for the monophasic group, while remaining unchanged at 12 months for the triphasic group. The monophasic preparation appeared to lower total, LDL and HDL cholesterols to a greater extent at 3 months than the triphasic preparation. Compared with IUD users, for the monophasic group, both total and HDL cholesterols were significantly lower at 3 months and HDL and LDL cholesterols were lower at 12 months. In addition, ratios of HDL cholesterol/LDL cholesterol and HDL cholesterol/total cholesterol were significantly lower at 12 months. Changes in triglycerides were minimal for both pill groups. However, at 3 months, triglycerides for the triphasic group were significantly higher than the IUD users, but this observation was not of any clinical importance since comparison of changes with their respective pretreatment values were not statistically significant. These results indicate that these changes are related to the dosage and estrogen-progestogen ratio of the preparation. Furthermore, the monophasic preparation may have a disadvantage over the triphasic preparation since it appears to cause more disturbance in lipid metabolism. However, it is noted that these changes in lipids and lipoproteins were minimal and did not appear to be of any clinical significance. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/2125546/A_comparative_study_of_the_effects_of_a_monophasic_and_a_triphasic_oral_contraceptive_containing_ethinyl_estradiol_and_levonorgestrel_on_lipid_and_lipoprotein_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(90)90081-6 DB - PRIME DP - Unbound Medicine ER -