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Electrochemical detection of anticancer drug topotecan using nano-acetylene black film.
Colloids Surf B Biointerfaces. 2011 May 01; 84(1):135-9.CS

Abstract

Topotecan, a novel anticancer drug, has been widely used in the treatment of ovarian and cervical cancers. Herein, acetylene black (AB) nanoparticles were used to modify the electrode surface, and the electrochemical behavior of topotecan was examined. At the AB film surface, an irreversible oxidation peak was observed for topotecan, and the response signal greatly increased. The influences of pH value, amount of AB, accumulation potential and time were investigated. As a result, a novel electrochemical method with high sensitivity and rapid response was developed for the detection of topotecan. The linear range is from 2 μg L(-1) to 0.4 mg L(-1), and the limit of detection is 1.45 μg L(-1) (or 3.17×10(-9) M). The method was successfully used to detect topotecan in blood serum, and the results consisted with the values that obtained by high performance liquid chromatography.

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Authors+Show Affiliations

Cheng Q
MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Du Y
No affiliation info available
Wu K
No affiliation info available
Chen J
No affiliation info available
Zhou Y
No affiliation info available

MeSH

AcetyleneAntineoplastic AgentsChromatography, High Pressure LiquidElectrochemistryNanoparticlesSurface PropertiesTopotecan

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21255983

Citation

Cheng, Qin, et al. "Electrochemical Detection of Anticancer Drug Topotecan Using Nano-acetylene Black Film." Colloids and Surfaces. B, Biointerfaces, vol. 84, no. 1, 2011, pp. 135-9.
Cheng Q, Du Y, Wu K, et al. Electrochemical detection of anticancer drug topotecan using nano-acetylene black film. Colloids Surf B Biointerfaces. 2011;84(1):135-9.
Cheng, Q., Du, Y., Wu, K., Chen, J., & Zhou, Y. (2011). Electrochemical detection of anticancer drug topotecan using nano-acetylene black film. Colloids and Surfaces. B, Biointerfaces, 84(1), 135-9. https://doi.org/10.1016/j.colsurfb.2010.12.027
Cheng Q, et al. Electrochemical Detection of Anticancer Drug Topotecan Using Nano-acetylene Black Film. Colloids Surf B Biointerfaces. 2011 May 1;84(1):135-9. PubMed PMID: 21255983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical detection of anticancer drug topotecan using nano-acetylene black film. AU - Cheng,Qin, AU - Du,Yu, AU - Wu,Kangbing, AU - Chen,Jianwei, AU - Zhou,Yikai, Y1 - 2010/12/29/ PY - 2010/11/10/received PY - 2010/12/21/revised PY - 2010/12/21/accepted PY - 2011/1/25/entrez PY - 2011/1/25/pubmed PY - 2011/6/2/medline SP - 135 EP - 9 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 84 IS - 1 N2 - Topotecan, a novel anticancer drug, has been widely used in the treatment of ovarian and cervical cancers. Herein, acetylene black (AB) nanoparticles were used to modify the electrode surface, and the electrochemical behavior of topotecan was examined. At the AB film surface, an irreversible oxidation peak was observed for topotecan, and the response signal greatly increased. The influences of pH value, amount of AB, accumulation potential and time were investigated. As a result, a novel electrochemical method with high sensitivity and rapid response was developed for the detection of topotecan. The linear range is from 2 μg L(-1) to 0.4 mg L(-1), and the limit of detection is 1.45 μg L(-1) (or 3.17×10(-9) M). The method was successfully used to detect topotecan in blood serum, and the results consisted with the values that obtained by high performance liquid chromatography. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/21255983/Electrochemical_detection_of_anticancer_drug_topotecan_using_nano_acetylene_black_film_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(10)00712-5 DB - PRIME DP - Unbound Medicine ER -