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Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study.

Abstract

BACKGROUND

The oxidant/antioxidant balance in lung tissue is hypothesised to contribute to the risk of chronic obstructive pulmonary disease (COPD). Observational studies consistently report higher antioxidant status associated with lower COPD risk, but few randomised studies have been reported.

METHODS

A post hoc analysis of 38,597 women without chronic lung disease at baseline was conducted in the Women's Health Study (WHS) to test the effect of vitamin E on the risk of incident chronic lung disease. The WHS is a randomised double-blind placebo-controlled factorial trial of vitamin E (600 IU every other day) and aspirin (100 mg every other day) in female health professionals aged≥45 years. Using Cox proportional hazards models, the effect of randomised vitamin E assignment on self-reported physician-diagnosed chronic lung disease was evaluated.

RESULTS

During 10 years of follow-up (376,710 person-years), 760 first occurrences of chronic lung disease were reported in the vitamin E arm compared with 846 in the placebo arm (HR 0.90; 95% CI 0.81 to 0.99; p=0.029). This 10% reduction in the risk of incident chronic lung disease was not modified by cigarette smoking, age, randomised aspirin assignment, multivitamin use or dietary vitamin E intake (minimum p for interaction=0.19). Current cigarette smoking was a strong predictor of chronic lung disease risk (HR 4.17; 95% CI 3.70 to 4.70; vs. never smokers).

CONCLUSIONS

In this large randomised trial, assignment to 600 IU vitamin E led to a 10% reduction in the risk of chronic lung disease in women.

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  • Authors+Show Affiliations

    ,

    Cornell University, Ithaca, NY 14853, USA.

    , , ,

    Source

    Thorax 66:4 2011 Apr pg 320-5

    MeSH

    Aged
    Antioxidants
    Chronic Disease
    Dietary Supplements
    Drug Administration Schedule
    Epidemiologic Methods
    Female
    Humans
    Lung Diseases
    Middle Aged
    United States
    alpha-Tocopherol

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21257986

    Citation

    Agler, Anne H., et al. "Randomised Vitamin E Supplementation and Risk of Chronic Lung Disease in the Women's Health Study." Thorax, vol. 66, no. 4, 2011, pp. 320-5.
    Agler AH, Kurth T, Gaziano JM, et al. Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study. Thorax. 2011;66(4):320-5.
    Agler, A. H., Kurth, T., Gaziano, J. M., Buring, J. E., & Cassano, P. A. (2011). Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study. Thorax, 66(4), pp. 320-5. doi:10.1136/thx.2010.155028.
    Agler AH, et al. Randomised Vitamin E Supplementation and Risk of Chronic Lung Disease in the Women's Health Study. Thorax. 2011;66(4):320-5. PubMed PMID: 21257986.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study. AU - Agler,Anne H, AU - Kurth,Tobias, AU - Gaziano,J Michael, AU - Buring,Julie E, AU - Cassano,Patricia A, Y1 - 2011/01/21/ PY - 2011/1/25/entrez PY - 2011/1/25/pubmed PY - 2011/5/18/medline SP - 320 EP - 5 JF - Thorax JO - Thorax VL - 66 IS - 4 N2 - BACKGROUND: The oxidant/antioxidant balance in lung tissue is hypothesised to contribute to the risk of chronic obstructive pulmonary disease (COPD). Observational studies consistently report higher antioxidant status associated with lower COPD risk, but few randomised studies have been reported. METHODS: A post hoc analysis of 38,597 women without chronic lung disease at baseline was conducted in the Women's Health Study (WHS) to test the effect of vitamin E on the risk of incident chronic lung disease. The WHS is a randomised double-blind placebo-controlled factorial trial of vitamin E (600 IU every other day) and aspirin (100 mg every other day) in female health professionals aged≥45 years. Using Cox proportional hazards models, the effect of randomised vitamin E assignment on self-reported physician-diagnosed chronic lung disease was evaluated. RESULTS: During 10 years of follow-up (376,710 person-years), 760 first occurrences of chronic lung disease were reported in the vitamin E arm compared with 846 in the placebo arm (HR 0.90; 95% CI 0.81 to 0.99; p=0.029). This 10% reduction in the risk of incident chronic lung disease was not modified by cigarette smoking, age, randomised aspirin assignment, multivitamin use or dietary vitamin E intake (minimum p for interaction=0.19). Current cigarette smoking was a strong predictor of chronic lung disease risk (HR 4.17; 95% CI 3.70 to 4.70; vs. never smokers). CONCLUSIONS: In this large randomised trial, assignment to 600 IU vitamin E led to a 10% reduction in the risk of chronic lung disease in women. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/21257986/full_citation L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=21257986 DB - PRIME DP - Unbound Medicine ER -