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[Molecular heterogeneity of prolactin and gonadotropins in some forms of sterility].
Ginecol Obstet Mex. 1990 Apr-May; 58 Suppl 1:9-13.GO

Abstract

In this paper are presented some chromatographic studies for partition of different molecular forms of prolactin (PRL), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in infertile women. Serum from three patients with prolactinoma and six with premature ovarian failure were fractionated in Sephadex G-100, and eighty fractions were collected, where PRL or FSH/LH were measured by radioimmunoassay, according with each case. Patients with prolactinoma showed two different chromatographic patterns for PRL. Two women with secondary amenorrhea and galactorrhea showed predominance of "little" PRL. In contrast, the patients with primary amenorrhea and galactorrhea showed only "big" PRL and "big-big" PRL. Among the patients with premature ovarian failure, two had chromosomal mosaicism, two had refractory ovarian syndrome and the other two had idiopathic premature ovarian failure. In these patients were found the presence of several molecular forms of FSH and LH, with different chromatographic profiles to those observed in normal young women and postmenopausal women. These results are indicating the presence of several molecular forms of pituitary hormones in patients with prolactinoma and premature ovarian failure.

Authors+Show Affiliations

Unidad de Investigación en Endocrinología, Hospital Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, D.F.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

2125965

Citation

Morán, C, et al. "[Molecular Heterogeneity of Prolactin and Gonadotropins in some Forms of Sterility]." Ginecologia Y Obstetricia De Mexico, vol. 58 Suppl 1, 1990, pp. 9-13.
Morán C, Fonseca ME, Ochoa R, et al. [Molecular heterogeneity of prolactin and gonadotropins in some forms of sterility]. Ginecol Obstet Mex. 1990;58 Suppl 1:9-13.
Morán, C., Fonseca, M. E., Ochoa, R., Masón, M., Gama, R., & Zárate, A. (1990). [Molecular heterogeneity of prolactin and gonadotropins in some forms of sterility]. Ginecologia Y Obstetricia De Mexico, 58 Suppl 1, 9-13.
Morán C, et al. [Molecular Heterogeneity of Prolactin and Gonadotropins in some Forms of Sterility]. Ginecol Obstet Mex. 1990 Apr-May;58 Suppl 1:9-13. PubMed PMID: 2125965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Molecular heterogeneity of prolactin and gonadotropins in some forms of sterility]. AU - Morán,C, AU - Fonseca,M E, AU - Ochoa,R, AU - Masón,M, AU - Gama,R, AU - Zárate,A, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 9 EP - 13 JF - Ginecologia y obstetricia de Mexico JO - Ginecol Obstet Mex VL - 58 Suppl 1 N2 - In this paper are presented some chromatographic studies for partition of different molecular forms of prolactin (PRL), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in infertile women. Serum from three patients with prolactinoma and six with premature ovarian failure were fractionated in Sephadex G-100, and eighty fractions were collected, where PRL or FSH/LH were measured by radioimmunoassay, according with each case. Patients with prolactinoma showed two different chromatographic patterns for PRL. Two women with secondary amenorrhea and galactorrhea showed predominance of "little" PRL. In contrast, the patients with primary amenorrhea and galactorrhea showed only "big" PRL and "big-big" PRL. Among the patients with premature ovarian failure, two had chromosomal mosaicism, two had refractory ovarian syndrome and the other two had idiopathic premature ovarian failure. In these patients were found the presence of several molecular forms of FSH and LH, with different chromatographic profiles to those observed in normal young women and postmenopausal women. These results are indicating the presence of several molecular forms of pituitary hormones in patients with prolactinoma and premature ovarian failure. SN - 0300-9041 UR - https://www.unboundmedicine.com/medline/citation/2125965/[Molecular_heterogeneity_of_prolactin_and_gonadotropins_in_some_forms_of_sterility]_ L2 - https://medlineplus.gov/femaleinfertility.html DB - PRIME DP - Unbound Medicine ER -