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Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice.
Pharmacol Biochem Behav. 2011 Apr; 98(2):286-91.PB

Abstract

Many studies of Parkinson's disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson's disease.

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Authors+Show Affiliations

Mu X
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Xian Nong Tan Street, Beijing 100050, China.
He GR
No affiliation info available
Yuan X
No affiliation info available
Li XX
No affiliation info available
Du GH
No affiliation info available

MeSH

AnimalsAntioxidantsBehavior, AnimalBrainCorpus StriatumDopamineFlavanonesGlutathione PeroxidaseMPTP PoisoningMaleMalondialdehydeMiceMice, Inbred C57BLNeuronsOxidative StressSubstantia NigraSuperoxide DismutaseTyrosine 3-Monooxygenase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21262257

Citation

Mu, Xin, et al. "Baicalein Protects the Brain Against Neuron Impairments Induced By MPTP in C57BL/6 Mice." Pharmacology, Biochemistry, and Behavior, vol. 98, no. 2, 2011, pp. 286-91.
Mu X, He GR, Yuan X, et al. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice. Pharmacol Biochem Behav. 2011;98(2):286-91.
Mu, X., He, G. R., Yuan, X., Li, X. X., & Du, G. H. (2011). Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice. Pharmacology, Biochemistry, and Behavior, 98(2), 286-91. https://doi.org/10.1016/j.pbb.2011.01.011
Mu X, et al. Baicalein Protects the Brain Against Neuron Impairments Induced By MPTP in C57BL/6 Mice. Pharmacol Biochem Behav. 2011;98(2):286-91. PubMed PMID: 21262257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice. AU - Mu,Xin, AU - He,Guo-Rong, AU - Yuan,Xia, AU - Li,Xiao-Xiu, AU - Du,Guan-Hua, Y1 - 2011/01/22/ PY - 2010/09/30/received PY - 2011/01/06/revised PY - 2011/01/16/accepted PY - 2011/1/26/entrez PY - 2011/1/26/pubmed PY - 2011/7/9/medline SP - 286 EP - 91 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 98 IS - 2 N2 - Many studies of Parkinson's disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson's disease. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/21262257/Baicalein_protects_the_brain_against_neuron_impairments_induced_by_MPTP_in_C57BL/6_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(11)00025-6 DB - PRIME DP - Unbound Medicine ER -