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The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials.
Thromb Haemost 2011; 105(4):579-85TH

Abstract

It was the objective of this work to systematically evaluate the role of vitamin E supplementation in the prevention of stroke. Eligible studies were identified from Medline, Embase and Cochrane Library. The efficacy data is the relative risk (RR) for the events of stroke. Thirteen randomised controlled trials (RCTs), with 166,282 participants in total, were analysed. The pooled results showed no significant benefit in the vitamin E group with respect to stroke of any type (RR 1.01; 95% confidence interval [CI]: 0.96, 1.07); ischaemic stroke (RR 1.01; 95% CI: 0.94, 1.09), haemorrhagic stroke (RR 1.12; 95% CI: 0.94, 1.33), fatal stroke (RR 0.94; 95% CI: 0.77, 1.14), and non-fatal stroke (RR 0.99; 95% CI: 0.91, 1.08). Administration of vitamin E 300 IU/day or more also gain no benefit (RR 0.99; 95% CI: 0.92, 1.06), as well as vitamin E less than 300 IU (RR 1.05; 95% CI: 0.96, 1.15). Vitamin E supplementation gained benefit of preventing stroke for neither healthy people (0.92; 0.83, 1.03) nor others at high risks in baseline (RR 1.05; 95% CI: 0.98, 1.12). Administration of synthetic vitamin E gain no benefit (RR 1.02; 95% CI: 0.96, 1.09), as well as the natural source vitamin E (RR 0.99; 95% CI: 0.89, 1.09). In conclusion, there is a lack of statistically significant or clinically important benefit of vitamin E supplementation in the prevention of stroke.

Authors+Show Affiliations

Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

21264448

Citation

Bin, Qiong, et al. "The Role of Vitamin E (tocopherol) Supplementation in the Prevention of Stroke. a Meta-analysis of 13 Randomised Controlled Trials." Thrombosis and Haemostasis, vol. 105, no. 4, 2011, pp. 579-85.
Bin Q, Hu X, Cao Y, et al. The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials. Thromb Haemost. 2011;105(4):579-85.
Bin, Q., Hu, X., Cao, Y., & Gao, F. (2011). The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials. Thrombosis and Haemostasis, 105(4), pp. 579-85. doi:10.1160/TH10-11-0729.
Bin Q, et al. The Role of Vitamin E (tocopherol) Supplementation in the Prevention of Stroke. a Meta-analysis of 13 Randomised Controlled Trials. Thromb Haemost. 2011;105(4):579-85. PubMed PMID: 21264448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials. AU - Bin,Qiong, AU - Hu,Xueying, AU - Cao,Yunfei, AU - Gao,Feng, Y1 - 2011/01/25/ PY - 2010/11/15/received PY - 2010/12/11/accepted PY - 2011/1/26/entrez PY - 2011/1/26/pubmed PY - 2011/8/16/medline SP - 579 EP - 85 JF - Thrombosis and haemostasis JO - Thromb. Haemost. VL - 105 IS - 4 N2 - It was the objective of this work to systematically evaluate the role of vitamin E supplementation in the prevention of stroke. Eligible studies were identified from Medline, Embase and Cochrane Library. The efficacy data is the relative risk (RR) for the events of stroke. Thirteen randomised controlled trials (RCTs), with 166,282 participants in total, were analysed. The pooled results showed no significant benefit in the vitamin E group with respect to stroke of any type (RR 1.01; 95% confidence interval [CI]: 0.96, 1.07); ischaemic stroke (RR 1.01; 95% CI: 0.94, 1.09), haemorrhagic stroke (RR 1.12; 95% CI: 0.94, 1.33), fatal stroke (RR 0.94; 95% CI: 0.77, 1.14), and non-fatal stroke (RR 0.99; 95% CI: 0.91, 1.08). Administration of vitamin E 300 IU/day or more also gain no benefit (RR 0.99; 95% CI: 0.92, 1.06), as well as vitamin E less than 300 IU (RR 1.05; 95% CI: 0.96, 1.15). Vitamin E supplementation gained benefit of preventing stroke for neither healthy people (0.92; 0.83, 1.03) nor others at high risks in baseline (RR 1.05; 95% CI: 0.98, 1.12). Administration of synthetic vitamin E gain no benefit (RR 1.02; 95% CI: 0.96, 1.09), as well as the natural source vitamin E (RR 0.99; 95% CI: 0.89, 1.09). In conclusion, there is a lack of statistically significant or clinically important benefit of vitamin E supplementation in the prevention of stroke. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/21264448/The_role_of_vitamin_E__tocopherol__supplementation_in_the_prevention_of_stroke__A_meta_analysis_of_13_randomised_controlled_trials_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1160/TH10-11-0729 DB - PRIME DP - Unbound Medicine ER -