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The STATus of PD-L1 (B7-H1) on tolerogenic APCs.
Eur J Immunol. 2011 Feb; 41(2):286-90.EJ

Abstract

Expression by DCs of co-inhibitory molecules such as programmed death ligand-1 (PD-L1/B7-H1/CD274), a member of the B7 superfamily, is crucial for the downregulation of T-cell responses and the maintenance of immune homeostasis. Exposure of immature DCs to danger-associated molecular patterns (DAMPS) or pathogen-associated molecular patterns (PAMPs) generally results in their maturation and acquisition of immunostimulatory function. However, exposure of DCs to TLR ligands early during their differentiation can inhibit further differentiation and confer tolerogenic properties on these APCs. A report in this issue of The European Journal of Immunology reveals that early inhibition of human DC differentiation from blood monocytes by TLR agonists is associated with a tolerogenic phenotype and Treg generation. The tolerogenic function of these APCs is dependent on MAPK-induced IL-6 and IL-10 production, which drives STAT-3-mediated PD-L1 expression. These observations link IL-10 and IL-6 to PD-L1 expression, providing a new dimension to the anti-inflammatory properties of these cytokines. These findings also have implications for understanding the inherent function of DCs in non-lymphoid tissues such as the liver and lung, where they are exposed to PAMPs that are found constitutively in the local microenvironment.

Authors+Show Affiliations

Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

Language

eng

PubMed ID

21267998

Citation

Sumpter, Tina L., and Angus W. Thomson. "The STATus of PD-L1 (B7-H1) On Tolerogenic APCs." European Journal of Immunology, vol. 41, no. 2, 2011, pp. 286-90.
Sumpter TL, Thomson AW. The STATus of PD-L1 (B7-H1) on tolerogenic APCs. Eur J Immunol. 2011;41(2):286-90.
Sumpter, T. L., & Thomson, A. W. (2011). The STATus of PD-L1 (B7-H1) on tolerogenic APCs. European Journal of Immunology, 41(2), 286-90. https://doi.org/10.1002/eji.201041353
Sumpter TL, Thomson AW. The STATus of PD-L1 (B7-H1) On Tolerogenic APCs. Eur J Immunol. 2011;41(2):286-90. PubMed PMID: 21267998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The STATus of PD-L1 (B7-H1) on tolerogenic APCs. AU - Sumpter,Tina L, AU - Thomson,Angus W, PY - 2011/1/27/entrez PY - 2011/1/27/pubmed PY - 2011/4/6/medline SP - 286 EP - 90 JF - European journal of immunology JO - Eur J Immunol VL - 41 IS - 2 N2 - Expression by DCs of co-inhibitory molecules such as programmed death ligand-1 (PD-L1/B7-H1/CD274), a member of the B7 superfamily, is crucial for the downregulation of T-cell responses and the maintenance of immune homeostasis. Exposure of immature DCs to danger-associated molecular patterns (DAMPS) or pathogen-associated molecular patterns (PAMPs) generally results in their maturation and acquisition of immunostimulatory function. However, exposure of DCs to TLR ligands early during their differentiation can inhibit further differentiation and confer tolerogenic properties on these APCs. A report in this issue of The European Journal of Immunology reveals that early inhibition of human DC differentiation from blood monocytes by TLR agonists is associated with a tolerogenic phenotype and Treg generation. The tolerogenic function of these APCs is dependent on MAPK-induced IL-6 and IL-10 production, which drives STAT-3-mediated PD-L1 expression. These observations link IL-10 and IL-6 to PD-L1 expression, providing a new dimension to the anti-inflammatory properties of these cytokines. These findings also have implications for understanding the inherent function of DCs in non-lymphoid tissues such as the liver and lung, where they are exposed to PAMPs that are found constitutively in the local microenvironment. SN - 1521-4141 UR - https://www.unboundmedicine.com/medline/citation/21267998/The_STATus_of_PD_L1__B7_H1__on_tolerogenic_APCs_ L2 - https://doi.org/10.1002/eji.201041353 DB - PRIME DP - Unbound Medicine ER -