Tags

Type your tag names separated by a space and hit enter

Modulation of histone acetylation by garlic sulfur compounds.

Abstract

Preclinical studies have shown that fresh garlic extracts, aged garlic, garlic oil and specific organosulfur compounds generated by processing garlic could alter carcinogen metabolism, inhibit tumor cell growth through induction of cell cycle arrest or apoptosis, or angiogenesis. In particular, recent studies have suggested that anticarcinogenic effects of certain garlic compounds may implicate at least in part a modulation of histone acetylation, a process involved in the regulation of gene expression, resulting from the inhibition of histone deacetylase activity. The aim of this review is to describe available data on sulfur compounds from garlic and histone acetylation and to discuss their potential for cancer prevention. Available data indicate that garlic compounds could inhibit histone deacetylase activity and induce histone hyperacetylation in vitro as well as in vivo. Sparse studies provide evidence of an involvement of histone acetylation in modulation of gene expression by diallyl disulfide and allyl mercaptan. These effects were observed at high concentrations. Further investigations are needed to determine if the HDAC inhibitory effects of garlic organosulfur compounds might play a role in primary cancer prevention at doses achievable by human diet.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    UMR U INSERM, Université Paris, Bobigny, France. nathalie.pecollo@jouy.inra.fr

    Source

    MeSH

    Acetylation
    Allyl Compounds
    Animals
    Anticarcinogenic Agents
    Antineoplastic Agents
    Apoptosis
    Cell Cycle
    Cell Line, Tumor
    Diet
    Female
    Garlic
    Gene Expression Regulation, Neoplastic
    Histone Deacetylase Inhibitors
    Histone Deacetylases
    Histones
    Humans
    Male
    Mice
    Mice, SCID
    Neoplasms
    Plant Extracts
    Plant Oils
    Rats
    Sulfur Compounds

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21269249

    Citation

    Druesne-Pecollo, Nathalie, and Paule Latino-Martel. "Modulation of Histone Acetylation By Garlic Sulfur Compounds." Anti-cancer Agents in Medicinal Chemistry, vol. 11, no. 3, 2011, pp. 254-9.
    Druesne-Pecollo N, Latino-Martel P. Modulation of histone acetylation by garlic sulfur compounds. Anticancer Agents Med Chem. 2011;11(3):254-9.
    Druesne-Pecollo, N., & Latino-Martel, P. (2011). Modulation of histone acetylation by garlic sulfur compounds. Anti-cancer Agents in Medicinal Chemistry, 11(3), pp. 254-9.
    Druesne-Pecollo N, Latino-Martel P. Modulation of Histone Acetylation By Garlic Sulfur Compounds. Anticancer Agents Med Chem. 2011;11(3):254-9. PubMed PMID: 21269249.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Modulation of histone acetylation by garlic sulfur compounds. AU - Druesne-Pecollo,Nathalie, AU - Latino-Martel,Paule, PY - 2011/03/02/received PY - 2011/03/21/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/7/22/medline SP - 254 EP - 9 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 11 IS - 3 N2 - Preclinical studies have shown that fresh garlic extracts, aged garlic, garlic oil and specific organosulfur compounds generated by processing garlic could alter carcinogen metabolism, inhibit tumor cell growth through induction of cell cycle arrest or apoptosis, or angiogenesis. In particular, recent studies have suggested that anticarcinogenic effects of certain garlic compounds may implicate at least in part a modulation of histone acetylation, a process involved in the regulation of gene expression, resulting from the inhibition of histone deacetylase activity. The aim of this review is to describe available data on sulfur compounds from garlic and histone acetylation and to discuss their potential for cancer prevention. Available data indicate that garlic compounds could inhibit histone deacetylase activity and induce histone hyperacetylation in vitro as well as in vivo. Sparse studies provide evidence of an involvement of histone acetylation in modulation of gene expression by diallyl disulfide and allyl mercaptan. These effects were observed at high concentrations. Further investigations are needed to determine if the HDAC inhibitory effects of garlic organosulfur compounds might play a role in primary cancer prevention at doses achievable by human diet. SN - 1875-5992 UR - https://www.unboundmedicine.com/medline/citation/21269249/Modulation_of_histone_acetylation_by_garlic_sulfur_compounds_ L2 - http://www.eurekaselect.com/73777/article DB - PRIME DP - Unbound Medicine ER -