Tags

Type your tag names separated by a space and hit enter

Modulation of histone acetylation by garlic sulfur compounds.
Anticancer Agents Med Chem 2011; 11(3):254-9AA

Abstract

Preclinical studies have shown that fresh garlic extracts, aged garlic, garlic oil and specific organosulfur compounds generated by processing garlic could alter carcinogen metabolism, inhibit tumor cell growth through induction of cell cycle arrest or apoptosis, or angiogenesis. In particular, recent studies have suggested that anticarcinogenic effects of certain garlic compounds may implicate at least in part a modulation of histone acetylation, a process involved in the regulation of gene expression, resulting from the inhibition of histone deacetylase activity. The aim of this review is to describe available data on sulfur compounds from garlic and histone acetylation and to discuss their potential for cancer prevention. Available data indicate that garlic compounds could inhibit histone deacetylase activity and induce histone hyperacetylation in vitro as well as in vivo. Sparse studies provide evidence of an involvement of histone acetylation in modulation of gene expression by diallyl disulfide and allyl mercaptan. These effects were observed at high concentrations. Further investigations are needed to determine if the HDAC inhibitory effects of garlic organosulfur compounds might play a role in primary cancer prevention at doses achievable by human diet.

Authors+Show Affiliations

UMR U INSERM, Université Paris, Bobigny, France. nathalie.pecollo@jouy.inra.frNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21269249

Citation

Druesne-Pecollo, Nathalie, and Paule Latino-Martel. "Modulation of Histone Acetylation By Garlic Sulfur Compounds." Anti-cancer Agents in Medicinal Chemistry, vol. 11, no. 3, 2011, pp. 254-9.
Druesne-Pecollo N, Latino-Martel P. Modulation of histone acetylation by garlic sulfur compounds. Anticancer Agents Med Chem. 2011;11(3):254-9.
Druesne-Pecollo, N., & Latino-Martel, P. (2011). Modulation of histone acetylation by garlic sulfur compounds. Anti-cancer Agents in Medicinal Chemistry, 11(3), pp. 254-9.
Druesne-Pecollo N, Latino-Martel P. Modulation of Histone Acetylation By Garlic Sulfur Compounds. Anticancer Agents Med Chem. 2011;11(3):254-9. PubMed PMID: 21269249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of histone acetylation by garlic sulfur compounds. AU - Druesne-Pecollo,Nathalie, AU - Latino-Martel,Paule, PY - 2011/03/02/received PY - 2011/03/21/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/7/22/medline SP - 254 EP - 9 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 11 IS - 3 N2 - Preclinical studies have shown that fresh garlic extracts, aged garlic, garlic oil and specific organosulfur compounds generated by processing garlic could alter carcinogen metabolism, inhibit tumor cell growth through induction of cell cycle arrest or apoptosis, or angiogenesis. In particular, recent studies have suggested that anticarcinogenic effects of certain garlic compounds may implicate at least in part a modulation of histone acetylation, a process involved in the regulation of gene expression, resulting from the inhibition of histone deacetylase activity. The aim of this review is to describe available data on sulfur compounds from garlic and histone acetylation and to discuss their potential for cancer prevention. Available data indicate that garlic compounds could inhibit histone deacetylase activity and induce histone hyperacetylation in vitro as well as in vivo. Sparse studies provide evidence of an involvement of histone acetylation in modulation of gene expression by diallyl disulfide and allyl mercaptan. These effects were observed at high concentrations. Further investigations are needed to determine if the HDAC inhibitory effects of garlic organosulfur compounds might play a role in primary cancer prevention at doses achievable by human diet. SN - 1875-5992 UR - https://www.unboundmedicine.com/medline/citation/21269249/Modulation_of_histone_acetylation_by_garlic_sulfur_compounds_ L2 - http://www.eurekaselect.com/73777/article DB - PRIME DP - Unbound Medicine ER -