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Anticancer effects of garlic and garlic-derived compounds for breast cancer control.
Anticancer Agents Med Chem 2011; 11(3):249-53AA

Abstract

Garlic and garlic-derived compounds reduce the development of mammary cancer in animals and suppress the growth of human breast cancer cells in culture. Oil-soluble compounds derived from garlic, such as diallyl disulfide (DADS), are more effective than water-soluble compounds in suppressing breast cancer. Mechanisms of action include the activation of metabolizing enzymes that detoxify carcinogens, the suppression of DNA adduct formation, the inhibition of the production of reactive oxygen species, the regulation of cell-cycle arrest and the induction of apoptosis. Selenium-enriched garlic or organoselenium compounds provide more potent protection against mammary carcinogenesis in rats and greater inhibition of breast cancer cells in culture than natural garlic or the respective organosulfur analogues. DADS synergizes the effect of eicosapentaenoic acid, a breast cancer suppressor, and antagonizes the effect of linoleic acid, a breast cancer enhancer. Moreover, garlic extract reduces the side effects caused by anti-cancer agents. Thus, garlic and garlic-derived compounds are promising candidates for breast cancer control.

Authors+Show Affiliations

Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, Japan. tsubura@takii.kmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21269259

Citation

Tsubura, Airo, et al. "Anticancer Effects of Garlic and Garlic-derived Compounds for Breast Cancer Control." Anti-cancer Agents in Medicinal Chemistry, vol. 11, no. 3, 2011, pp. 249-53.
Tsubura A, Lai YC, Kuwata M, et al. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anticancer Agents Med Chem. 2011;11(3):249-53.
Tsubura, A., Lai, Y. C., Kuwata, M., Uehara, N., & Yoshizawa, K. (2011). Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anti-cancer Agents in Medicinal Chemistry, 11(3), pp. 249-53.
Tsubura A, et al. Anticancer Effects of Garlic and Garlic-derived Compounds for Breast Cancer Control. Anticancer Agents Med Chem. 2011;11(3):249-53. PubMed PMID: 21269259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticancer effects of garlic and garlic-derived compounds for breast cancer control. AU - Tsubura,Airo, AU - Lai,Yen-Chang, AU - Kuwata,Maki, AU - Uehara,Norihisa, AU - Yoshizawa,Katsuhiko, PY - 2011/03/02/received PY - 2011/03/21/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/7/22/medline SP - 249 EP - 53 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 11 IS - 3 N2 - Garlic and garlic-derived compounds reduce the development of mammary cancer in animals and suppress the growth of human breast cancer cells in culture. Oil-soluble compounds derived from garlic, such as diallyl disulfide (DADS), are more effective than water-soluble compounds in suppressing breast cancer. Mechanisms of action include the activation of metabolizing enzymes that detoxify carcinogens, the suppression of DNA adduct formation, the inhibition of the production of reactive oxygen species, the regulation of cell-cycle arrest and the induction of apoptosis. Selenium-enriched garlic or organoselenium compounds provide more potent protection against mammary carcinogenesis in rats and greater inhibition of breast cancer cells in culture than natural garlic or the respective organosulfur analogues. DADS synergizes the effect of eicosapentaenoic acid, a breast cancer suppressor, and antagonizes the effect of linoleic acid, a breast cancer enhancer. Moreover, garlic extract reduces the side effects caused by anti-cancer agents. Thus, garlic and garlic-derived compounds are promising candidates for breast cancer control. SN - 1875-5992 UR - https://www.unboundmedicine.com/medline/citation/21269259/Anticancer_effects_of_garlic_and_garlic_derived_compounds_for_breast_cancer_control_ L2 - http://www.eurekaselect.com/73776/article DB - PRIME DP - Unbound Medicine ER -