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Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds.
Anticancer Agents Med Chem 2011; 11(3):267-71AA

Abstract

Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due to its multiple beneficial effects, contains a consistent number of OSCs, the majority of which are currently under investigation for their biological activities. Experimental animal and laboratory studies have shown strong evidence that garlic OSCs may affect cancer cells by promoting early mitotic arrest followed by apoptotic cell death without affecting healthy cells. The ability of OSCs to hinder cancer cell proliferation and viability tightly correlates with the length of the sulfur chain. Current data support a mechanism of mitotic arrest of cancer cells due to the alteration of the microtubule network, possibly as a consequence of the high reactivity of sulfur atoms against the thiol groups of different cellular macromolecules controlling crucial regulatory functions. Taken together, these findings indicate a promising potential for the use of garlic-derived sulfur compounds in chemoprevention and chemotherapy.

Authors+Show Affiliations

Laboratoire de Biologie Moléculaire et Cellulaire de Cancer, Hôpital Kirchberg, Luxemburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21269260

Citation

Cerella, Claudia, et al. "Chemical Properties and Mechanisms Determining the Anti-cancer Action of Garlic-derived Organic Sulfur Compounds." Anti-cancer Agents in Medicinal Chemistry, vol. 11, no. 3, 2011, pp. 267-71.
Cerella C, Dicato M, Jacob C, et al. Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anticancer Agents Med Chem. 2011;11(3):267-71.
Cerella, C., Dicato, M., Jacob, C., & Diederich, M. (2011). Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. Anti-cancer Agents in Medicinal Chemistry, 11(3), pp. 267-71.
Cerella C, et al. Chemical Properties and Mechanisms Determining the Anti-cancer Action of Garlic-derived Organic Sulfur Compounds. Anticancer Agents Med Chem. 2011;11(3):267-71. PubMed PMID: 21269260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds. AU - Cerella,Claudia, AU - Dicato,Mario, AU - Jacob,Claus, AU - Diederich,Marc, PY - 2011/03/02/received PY - 2011/03/21/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/7/22/medline SP - 267 EP - 71 JF - Anti-cancer agents in medicinal chemistry JO - Anticancer Agents Med Chem VL - 11 IS - 3 N2 - Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due to its multiple beneficial effects, contains a consistent number of OSCs, the majority of which are currently under investigation for their biological activities. Experimental animal and laboratory studies have shown strong evidence that garlic OSCs may affect cancer cells by promoting early mitotic arrest followed by apoptotic cell death without affecting healthy cells. The ability of OSCs to hinder cancer cell proliferation and viability tightly correlates with the length of the sulfur chain. Current data support a mechanism of mitotic arrest of cancer cells due to the alteration of the microtubule network, possibly as a consequence of the high reactivity of sulfur atoms against the thiol groups of different cellular macromolecules controlling crucial regulatory functions. Taken together, these findings indicate a promising potential for the use of garlic-derived sulfur compounds in chemoprevention and chemotherapy. SN - 1875-5992 UR - https://www.unboundmedicine.com/medline/citation/21269260/Chemical_properties_and_mechanisms_determining_the_anti_cancer_action_of_garlic_derived_organic_sulfur_compounds_ L2 - http://www.eurekaselect.com/73779/article DB - PRIME DP - Unbound Medicine ER -