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Rotenone, paraquat, and Parkinson's disease.
Environ Health Perspect. 2011 Jun; 119(6):866-72.EH

Abstract

BACKGROUND

Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans.

OBJECTIVES

Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans.

METHODS

We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists. Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case.

RESULTS

In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR)=1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR=2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR=2.5; 95% CI, 1.4-4.7).

CONCLUSIONS

PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.

Authors+Show Affiliations

The Parkinson's Institute, Sunnyvale, California 94085, USA. ctannermd@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21269927

Citation

Tanner, Caroline M., et al. "Rotenone, Paraquat, and Parkinson's Disease." Environmental Health Perspectives, vol. 119, no. 6, 2011, pp. 866-72.
Tanner CM, Kamel F, Ross GW, et al. Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect. 2011;119(6):866-72.
Tanner, C. M., Kamel, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., Marras, C., Bhudhikanok, G. S., Kasten, M., Chade, A. R., Comyns, K., Richards, M. B., Meng, C., Priestley, B., Fernandez, H. H., Cambi, F., Umbach, D. M., Blair, A., Sandler, D. P., & Langston, J. W. (2011). Rotenone, paraquat, and Parkinson's disease. Environmental Health Perspectives, 119(6), 866-72. https://doi.org/10.1289/ehp.1002839
Tanner CM, et al. Rotenone, Paraquat, and Parkinson's Disease. Environ Health Perspect. 2011;119(6):866-72. PubMed PMID: 21269927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rotenone, paraquat, and Parkinson's disease. AU - Tanner,Caroline M, AU - Kamel,Freya, AU - Ross,G Webster, AU - Hoppin,Jane A, AU - Goldman,Samuel M, AU - Korell,Monica, AU - Marras,Connie, AU - Bhudhikanok,Grace S, AU - Kasten,Meike, AU - Chade,Anabel R, AU - Comyns,Kathleen, AU - Richards,Marie Barber, AU - Meng,Cheryl, AU - Priestley,Benjamin, AU - Fernandez,Hubert H, AU - Cambi,Franca, AU - Umbach,David M, AU - Blair,Aaron, AU - Sandler,Dale P, AU - Langston,J William, Y1 - 2011/01/26/ PY - 2010/08/08/received PY - 2011/01/26/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/9/29/medline SP - 866 EP - 72 JF - Environmental health perspectives JO - Environ Health Perspect VL - 119 IS - 6 N2 - BACKGROUND: Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. OBJECTIVES: Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. METHODS: We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists. Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls:one case. RESULTS: In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR)=1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR=2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR=2.5; 95% CI, 1.4-4.7). CONCLUSIONS: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/21269927/Rotenone_paraquat_and_Parkinson's_disease_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.1002839?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -