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Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study.
Public Health Nutr. 2011 May; 14(5):882-8.PH

Abstract

OBJECTIVE

Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans.

SUBJECTS

Healthy volunteers (n 387) aged 55-87 years were recruited.

SETTING

Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70-87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55-70 years.

DESIGN

Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention.

RESULTS

Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55-70 years or the ≥70 years age group.

CONCLUSIONS

These results suggest that zinc does not benefit mood in healthy older people.

Links

Publisher Full Text

Authors+Show Affiliations

Stewart-Knox BJ
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT521SA, Northern Ireland, UK. b.knox@ulster.ac.uk
Rae G
No affiliation info available
Simpson EE
No affiliation info available
McConville C
No affiliation info available
O'Connor J
No affiliation info available
Polito A
No affiliation info available
Andriollo-Sanchez M
No affiliation info available
Coudray C
No affiliation info available
Strain JJ
No affiliation info available

MeSH

AffectAgedAged, 80 and overDietary SupplementsDouble-Blind MethodEuropeFemaleHumansMaleMiddle AgedTrace ElementsZinc

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21272413

Citation

Stewart-Knox, Barbara J., et al. "Supplemented Zinc Does Not Alter Mood in Healthy Older European Adults--a Randomised Placebo-controlled Trial: the Zenith Study." Public Health Nutrition, vol. 14, no. 5, 2011, pp. 882-8.
Stewart-Knox BJ, Rae G, Simpson EE, et al. Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study. Public Health Nutr. 2011;14(5):882-8.
Stewart-Knox, B. J., Rae, G., Simpson, E. E., McConville, C., O'Connor, J., Polito, A., Andriollo-Sanchez, M., Coudray, C., & Strain, J. J. (2011). Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study. Public Health Nutrition, 14(5), 882-8. https://doi.org/10.1017/S1368980010002764
Stewart-Knox BJ, et al. Supplemented Zinc Does Not Alter Mood in Healthy Older European Adults--a Randomised Placebo-controlled Trial: the Zenith Study. Public Health Nutr. 2011;14(5):882-8. PubMed PMID: 21272413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study. AU - Stewart-Knox,Barbara J, AU - Rae,Gordon, AU - Simpson,Ellen E A, AU - McConville,Chris, AU - O'Connor,Jacqueline, AU - Polito,Angela, AU - Andriollo-Sanchez,Maud, AU - Coudray,Charles, AU - Strain,J J, Y1 - 2011/01/28/ PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/6/11/medline SP - 882 EP - 8 JF - Public health nutrition JO - Public Health Nutr VL - 14 IS - 5 N2 - OBJECTIVE: Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans. SUBJECTS: Healthy volunteers (n 387) aged 55-87 years were recruited. SETTING: Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70-87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55-70 years. DESIGN: Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention. RESULTS: Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55-70 years or the ≥70 years age group. CONCLUSIONS: These results suggest that zinc does not benefit mood in healthy older people. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/21272413/Supplemented_zinc_does_not_alter_mood_in_healthy_older_European_adults__a_randomised_placebo_controlled_trial:_the_Zenith_study_ L2 - https://www.cambridge.org/core/product/identifier/S1368980010002764/type/journal_article DB - PRIME DP - Unbound Medicine ER -