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Histamine H(3) receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries.
Eur J Pharmacol. 2011 Mar 25; 655(1-3):67-73.EJ

Abstract

The rat mesenteric artery has been shown to be innervated by adrenergic vasoconstrictor nerves and calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves. The present study was designed to investigate the involvement of histamine H(3) receptors in the neurotransmission of perivascular adrenergic and CGRPergic nerves. The mesenteric vascular beds without an endothelium isolated from male Wistar rats were perfused with Krebs solution and perfusion pressure was measured. In preparations with resting tension, the selective H(3) receptor agonist (R)-α-methylhistamine (α-methylhistamine; 10-100nM) significantly reduced periarterial nerve stimulation (2-8Hz)-induced vasoconstriction and noradrenaline release in the perfusate without an effect on the vasoconstriction induced by exogenously injected noradrenaline (0.5, 1.0nmol). In preparations with active tone produced by methoxamine (2μM) and in the presence of guanethidine (5μM), the periarterial nerve stimulation (1, 2Hz)-induced vasodilator response was inhibited by α-methylhistamine (0.1-1μM) perfusion without affecting vasodilation induced by exogenously injected CGRP (5pmol). Clobenpropit (histamine H(3) receptor antagonist, 1μM) canceled the α-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation. These results suggest that the stimulation of H(3) receptors located in rat perivascular nerves inhibits presynaptically the neurotransmission of not only adrenergic nerves, but also CGRP nerves, by decreasing neurotransmitters.

Authors+Show Affiliations

Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21272571

Citation

Sun, Pengyuan, et al. "Histamine H(3) Receptor-mediated Modulation of Perivascular Nerve Transmission in Rat Mesenteric Arteries." European Journal of Pharmacology, vol. 655, no. 1-3, 2011, pp. 67-73.
Sun P, Takatori S, Jin X, et al. Histamine H(3) receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries. Eur J Pharmacol. 2011;655(1-3):67-73.
Sun, P., Takatori, S., Jin, X., Koyama, T., Tangsucharit, P., Li, S., Zamami, Y., Kitamura, Y., & Kawasaki, H. (2011). Histamine H(3) receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries. European Journal of Pharmacology, 655(1-3), 67-73. https://doi.org/10.1016/j.ejphar.2011.01.020
Sun P, et al. Histamine H(3) Receptor-mediated Modulation of Perivascular Nerve Transmission in Rat Mesenteric Arteries. Eur J Pharmacol. 2011 Mar 25;655(1-3):67-73. PubMed PMID: 21272571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine H(3) receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries. AU - Sun,Pengyuan, AU - Takatori,Shingo, AU - Jin,Xin, AU - Koyama,Toshihiro, AU - Tangsucharit,Panot, AU - Li,Simin, AU - Zamami,Yoshito, AU - Kitamura,Yoshihisa, AU - Kawasaki,Hiromu, Y1 - 2011/01/25/ PY - 2010/09/29/received PY - 2010/12/08/revised PY - 2011/01/07/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2011/7/13/medline SP - 67 EP - 73 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 655 IS - 1-3 N2 - The rat mesenteric artery has been shown to be innervated by adrenergic vasoconstrictor nerves and calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves. The present study was designed to investigate the involvement of histamine H(3) receptors in the neurotransmission of perivascular adrenergic and CGRPergic nerves. The mesenteric vascular beds without an endothelium isolated from male Wistar rats were perfused with Krebs solution and perfusion pressure was measured. In preparations with resting tension, the selective H(3) receptor agonist (R)-α-methylhistamine (α-methylhistamine; 10-100nM) significantly reduced periarterial nerve stimulation (2-8Hz)-induced vasoconstriction and noradrenaline release in the perfusate without an effect on the vasoconstriction induced by exogenously injected noradrenaline (0.5, 1.0nmol). In preparations with active tone produced by methoxamine (2μM) and in the presence of guanethidine (5μM), the periarterial nerve stimulation (1, 2Hz)-induced vasodilator response was inhibited by α-methylhistamine (0.1-1μM) perfusion without affecting vasodilation induced by exogenously injected CGRP (5pmol). Clobenpropit (histamine H(3) receptor antagonist, 1μM) canceled the α-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation. These results suggest that the stimulation of H(3) receptors located in rat perivascular nerves inhibits presynaptically the neurotransmission of not only adrenergic nerves, but also CGRP nerves, by decreasing neurotransmitters. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21272571/Histamine_H_3__receptor_mediated_modulation_of_perivascular_nerve_transmission_in_rat_mesenteric_arteries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)00060-4 DB - PRIME DP - Unbound Medicine ER -