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Changes in thalamus connectivity in mild cognitive impairment: evidence from resting state fMRI.
Eur J Radiol. 2012 Feb; 81(2):277-85.EJ

Abstract

PURPOSE

The subcortical region such as thalamus was believed to have close relationship with many cerebral cortexes which made it especially interesting in the study of functional connectivity. Here, we used resting state functional MRI (fMRI) to examine changes in thalamus connectivity in mild cognitive impairment (MCI), which presented a neuro-disconnection syndrome.

MATERIALS AND METHODS

Data from 14 patients and 14 healthy age-matched controls were analyzed. Thalamus connectivity was investigated by examination of the correlation between low frequency fMRI signal fluctuations in the thalamus and those in all other brain regions.

RESULTS

We found that functional connectivity between the left thalamus and a set of regions was decreased in MCI; these regions are: bilateral cuneus, middle occipital gyrus (MOG), superior frontal gyrus (SFG), medial prefrontal cortex (MPFC), precuneus, inferior frontal gyrus (IFG) and precentral gyrus (PreCG). There are also some regions showed reduced connectivity to right thalamus; these regions are bilateral cuneus, MOG, fusiform gyrus (FG), MPFC, paracentral lobe (PCL), precuneus, superior parietal lobe (SPL) and IFG. We also found increased functional connectivity between the left thalamus and the right thalamus in MCI.

CONCLUSION

The decreased connectivity between the thalamus and the other brain regions might indicate reduced integrity of thalamus-related cortical networks in MCI. Furthermore, the increased connectivity between the left and right thalamus suggest compensation for the loss of cognitive function. Briefly, impairment and compensation of thalamus connectivity coexist in the MCI patients.

Authors+Show Affiliations

Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21273022

Citation

Wang, Zhiqun, et al. "Changes in Thalamus Connectivity in Mild Cognitive Impairment: Evidence From Resting State FMRI." European Journal of Radiology, vol. 81, no. 2, 2012, pp. 277-85.
Wang Z, Jia X, Liang P, et al. Changes in thalamus connectivity in mild cognitive impairment: evidence from resting state fMRI. Eur J Radiol. 2012;81(2):277-85.
Wang, Z., Jia, X., Liang, P., Qi, Z., Yang, Y., Zhou, W., & Li, K. (2012). Changes in thalamus connectivity in mild cognitive impairment: evidence from resting state fMRI. European Journal of Radiology, 81(2), 277-85. https://doi.org/10.1016/j.ejrad.2010.12.044
Wang Z, et al. Changes in Thalamus Connectivity in Mild Cognitive Impairment: Evidence From Resting State FMRI. Eur J Radiol. 2012;81(2):277-85. PubMed PMID: 21273022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in thalamus connectivity in mild cognitive impairment: evidence from resting state fMRI. AU - Wang,Zhiqun, AU - Jia,Xiuqin, AU - Liang,Peipeng, AU - Qi,Zhigang, AU - Yang,Yanhui, AU - Zhou,Weidong, AU - Li,Kuncheng, Y1 - 2011/01/26/ PY - 2010/10/12/received PY - 2010/12/17/accepted PY - 2011/1/29/entrez PY - 2011/1/29/pubmed PY - 2012/5/18/medline SP - 277 EP - 85 JF - European journal of radiology JO - Eur J Radiol VL - 81 IS - 2 N2 - PURPOSE: The subcortical region such as thalamus was believed to have close relationship with many cerebral cortexes which made it especially interesting in the study of functional connectivity. Here, we used resting state functional MRI (fMRI) to examine changes in thalamus connectivity in mild cognitive impairment (MCI), which presented a neuro-disconnection syndrome. MATERIALS AND METHODS: Data from 14 patients and 14 healthy age-matched controls were analyzed. Thalamus connectivity was investigated by examination of the correlation between low frequency fMRI signal fluctuations in the thalamus and those in all other brain regions. RESULTS: We found that functional connectivity between the left thalamus and a set of regions was decreased in MCI; these regions are: bilateral cuneus, middle occipital gyrus (MOG), superior frontal gyrus (SFG), medial prefrontal cortex (MPFC), precuneus, inferior frontal gyrus (IFG) and precentral gyrus (PreCG). There are also some regions showed reduced connectivity to right thalamus; these regions are bilateral cuneus, MOG, fusiform gyrus (FG), MPFC, paracentral lobe (PCL), precuneus, superior parietal lobe (SPL) and IFG. We also found increased functional connectivity between the left thalamus and the right thalamus in MCI. CONCLUSION: The decreased connectivity between the thalamus and the other brain regions might indicate reduced integrity of thalamus-related cortical networks in MCI. Furthermore, the increased connectivity between the left and right thalamus suggest compensation for the loss of cognitive function. Briefly, impairment and compensation of thalamus connectivity coexist in the MCI patients. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/21273022/Changes_in_thalamus_connectivity_in_mild_cognitive_impairment:_evidence_from_resting_state_fMRI_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(10)00669-8 DB - PRIME DP - Unbound Medicine ER -