Rh(III)-catalyzed directed C-H olefination using an oxidizing directing group: mild, efficient, and versatile.J Am Chem Soc. 2011 Mar 02; 133(8):2350-3.JA
An efficient Rh(III)-catalyzed oxidative olefination by directed C-H bond activation of N-methoxybenzamides is reported. In this mild, practical, selective, and high-yielding process, the N-O bond acts as an internal oxidant. In addition, simply changing the substituent of the directing/oxidizing group results in the selective formation of valuable tetrahydroisoquinolinone products.