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Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy.
Int J Radiat Oncol Biol Phys. 2012 Feb 01; 82(2):626-34.IJ

Abstract

PURPOSE

The purpose of this study was to elucidate the efficacy and optimal method of radiotherapy in the management of solitary extramedullary plasmacytoma occurring in the head and neck regions (EMPHN).

METHODS AND MATERIALS

Sixty-seven patients (43 male and 24 female) diagnosed with EMPHN between 1983 and 2008 at 23 Japanese institutions were reviewed. The median patient age was 64 years (range, 12-83). The median dose administered was 50 Gy (range, 30-64 Gy). Survival data were calculated by the Kaplan-Meier method.

RESULTS

The median follow-up duration was 63 months. Major tumor sites were nasal or paranasal cavities in 36 (54%) patients, oropharynx or nasopharynx in 16 (23%) patients, orbita in 6 (9%) patients, and larynx in 3 (5%) patients. The 5- and 10-year local control rates were 95% and 87%, whereas the 5- and 10-year disease-free survival rates were 56% and 54%, respectively. There were 5 (7.5%), 12 (18%), and 8 (12%) patients who experienced local failure, distant metastasis, and progression to multiple myeloma, respectively. In total, 18 patients died, including 10 (15%) patients who died due to complications from EMPHN. The 5- and 10-year overall survival (OS) rates were 73% and 56%, respectively. Radiotherapy combined with surgery was identified as the lone significant prognostic factor for OS (p = 0.04), whereas age, gender, radiation dose, tumor size, and chemotherapy were not predictive. No patient experienced any severe acute morbidity.

CONCLUSIONS

Radiotherapy was quite effective and safe for patients with EMPHN. Radiotherapy combined with surgery produced a better outcome according to survival rates. These findings require confirmation by further studies with larger numbers of patients with EMPHN.

Authors+Show Affiliations

Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe City, Hyogo 650-0017, Japan. rsasaki@med.kobe-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21277117

Citation

Sasaki, Ryohei, et al. "Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated With Curative Radiotherapy." International Journal of Radiation Oncology, Biology, Physics, vol. 82, no. 2, 2012, pp. 626-34.
Sasaki R, Yasuda K, Abe E, et al. Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. Int J Radiat Oncol Biol Phys. 2012;82(2):626-34.
Sasaki, R., Yasuda, K., Abe, E., Uchida, N., Kawashima, M., Uno, T., Fujiwara, M., Shioyama, Y., Kagami, Y., Shibamoto, Y., Nakata, K., Takada, Y., Kawabe, T., Uehara, K., Nibu, K., & Yamada, S. (2012). Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 82(2), 626-34. https://doi.org/10.1016/j.ijrobp.2010.11.037
Sasaki R, et al. Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated With Curative Radiotherapy. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):626-34. PubMed PMID: 21277117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. AU - Sasaki,Ryohei, AU - Yasuda,Koichi, AU - Abe,Eisuke, AU - Uchida,Nobue, AU - Kawashima,Mitsuhiko, AU - Uno,Takashi, AU - Fujiwara,Masayuki, AU - Shioyama,Yoshiyuki, AU - Kagami,Yoshikazu, AU - Shibamoto,Yuta, AU - Nakata,Kensei, AU - Takada,Yoshie, AU - Kawabe,Tetsuya, AU - Uehara,Kazuyuki, AU - Nibu,Kenichi, AU - Yamada,Syogo, Y1 - 2011/01/27/ PY - 2010/08/19/received PY - 2010/11/06/revised PY - 2010/11/09/accepted PY - 2011/2/1/entrez PY - 2011/2/1/pubmed PY - 2012/3/17/medline SP - 626 EP - 34 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 82 IS - 2 N2 - PURPOSE: The purpose of this study was to elucidate the efficacy and optimal method of radiotherapy in the management of solitary extramedullary plasmacytoma occurring in the head and neck regions (EMPHN). METHODS AND MATERIALS: Sixty-seven patients (43 male and 24 female) diagnosed with EMPHN between 1983 and 2008 at 23 Japanese institutions were reviewed. The median patient age was 64 years (range, 12-83). The median dose administered was 50 Gy (range, 30-64 Gy). Survival data were calculated by the Kaplan-Meier method. RESULTS: The median follow-up duration was 63 months. Major tumor sites were nasal or paranasal cavities in 36 (54%) patients, oropharynx or nasopharynx in 16 (23%) patients, orbita in 6 (9%) patients, and larynx in 3 (5%) patients. The 5- and 10-year local control rates were 95% and 87%, whereas the 5- and 10-year disease-free survival rates were 56% and 54%, respectively. There were 5 (7.5%), 12 (18%), and 8 (12%) patients who experienced local failure, distant metastasis, and progression to multiple myeloma, respectively. In total, 18 patients died, including 10 (15%) patients who died due to complications from EMPHN. The 5- and 10-year overall survival (OS) rates were 73% and 56%, respectively. Radiotherapy combined with surgery was identified as the lone significant prognostic factor for OS (p = 0.04), whereas age, gender, radiation dose, tumor size, and chemotherapy were not predictive. No patient experienced any severe acute morbidity. CONCLUSIONS: Radiotherapy was quite effective and safe for patients with EMPHN. Radiotherapy combined with surgery produced a better outcome according to survival rates. These findings require confirmation by further studies with larger numbers of patients with EMPHN. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/21277117/Multi_institutional_analysis_of_solitary_extramedullary_plasmacytoma_of_the_head_and_neck_treated_with_curative_radiotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(10)03657-6 DB - PRIME DP - Unbound Medicine ER -