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Association of maternal anemia with increased wheeze and asthma in children.
Ann Allergy Asthma Immunol. 2011 Feb; 106(2):131-139.e1.AA

Abstract

BACKGROUND

Increasing interest has focused on maternal nutrition and micronutrient status during pregnancy and respiratory disease development in the offspring.

OBJECTIVE

To examine the relationship between maternal anemia in pregnancy with wheeze and asthma in early childhood.

METHODS

The cohort included children of women followed through pregnancy and recontacted when the child was 6 years of age to evaluate respiratory health. Exposure was assessed using maternal anemia diagnosis and hemoglobin (Hgb) < 11 during delivery hospitalization. Study outcomes include wheezing in early childhood; patterns of wheeze from birth to age 6 (early-onset transient wheeze; late-onset wheeze; early-onset persistent wheeze); and diagnosis of childhood asthma.

RESULTS

Maternal anemia was reported by 11.9% of mothers and was associated with recurrent infant wheeze in the first year (adjusted odds ratio [ORa] = 2.17, 95% confidence interval [CI] 1.18, 4.00), wheezing before age 3 (Ora = 2.42, 95% CI 1.38, 4.23), and early-onset transient and early-onset persistent wheeze patterns (Ora = 2.81, 95%CI 1.38, 5.72, and Ora = 2.07, 95% CI 1.02, 4.22), respectively. Among children of mothers with asthma, maternal anemia was associated with recurrent wheeze in year 1 (Ora = 4.22, 95% CI 1.65, 10.80) and wheeze before age 3 (Ora = 2.73, 95% CI 1.17, 6.35). Offspring of mothers with asthma also had increased odds of asthma diagnosis (Ora = 2.53, 95% CI 1.04, 6.17) and current asthma (Ora = 3.46, 95% CI 1.45, 8.26).

CONCLUSIONS

Maternal anemia during pregnancy is associated with infant respiratory health outcomes. If this observation is replicated, maternal anemia may be a target for intervention and future research.

Authors+Show Affiliations

Brown University, Department of Community Health/Epidemiology, Providence, RI, USA. Elizabeth_triche@brown.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21277514

Citation

Triche, Elizabeth W., et al. "Association of Maternal Anemia With Increased Wheeze and Asthma in Children." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 106, no. 2, 2011, pp. 131-139.e1.
Triche EW, Lundsberg LS, Wickner PG, et al. Association of maternal anemia with increased wheeze and asthma in children. Ann Allergy Asthma Immunol. 2011;106(2):131-139.e1.
Triche, E. W., Lundsberg, L. S., Wickner, P. G., Belanger, K., Leaderer, B. P., & Bracken, M. B. (2011). Association of maternal anemia with increased wheeze and asthma in children. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 106(2), 131-e1. https://doi.org/10.1016/j.anai.2010.11.007
Triche EW, et al. Association of Maternal Anemia With Increased Wheeze and Asthma in Children. Ann Allergy Asthma Immunol. 2011;106(2):131-139.e1. PubMed PMID: 21277514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of maternal anemia with increased wheeze and asthma in children. AU - Triche,Elizabeth W, AU - Lundsberg,Lisbet S, AU - Wickner,Paige G, AU - Belanger,Kathleen, AU - Leaderer,Brian P, AU - Bracken,Michael B, Y1 - 2011/01/08/ PY - 2010/08/09/received PY - 2010/10/29/revised PY - 2010/11/05/accepted PY - 2011/2/1/entrez PY - 2011/2/1/pubmed PY - 2011/3/15/medline SP - 131 EP - 139.e1 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 106 IS - 2 N2 - BACKGROUND: Increasing interest has focused on maternal nutrition and micronutrient status during pregnancy and respiratory disease development in the offspring. OBJECTIVE: To examine the relationship between maternal anemia in pregnancy with wheeze and asthma in early childhood. METHODS: The cohort included children of women followed through pregnancy and recontacted when the child was 6 years of age to evaluate respiratory health. Exposure was assessed using maternal anemia diagnosis and hemoglobin (Hgb) < 11 during delivery hospitalization. Study outcomes include wheezing in early childhood; patterns of wheeze from birth to age 6 (early-onset transient wheeze; late-onset wheeze; early-onset persistent wheeze); and diagnosis of childhood asthma. RESULTS: Maternal anemia was reported by 11.9% of mothers and was associated with recurrent infant wheeze in the first year (adjusted odds ratio [ORa] = 2.17, 95% confidence interval [CI] 1.18, 4.00), wheezing before age 3 (Ora = 2.42, 95% CI 1.38, 4.23), and early-onset transient and early-onset persistent wheeze patterns (Ora = 2.81, 95%CI 1.38, 5.72, and Ora = 2.07, 95% CI 1.02, 4.22), respectively. Among children of mothers with asthma, maternal anemia was associated with recurrent wheeze in year 1 (Ora = 4.22, 95% CI 1.65, 10.80) and wheeze before age 3 (Ora = 2.73, 95% CI 1.17, 6.35). Offspring of mothers with asthma also had increased odds of asthma diagnosis (Ora = 2.53, 95% CI 1.04, 6.17) and current asthma (Ora = 3.46, 95% CI 1.45, 8.26). CONCLUSIONS: Maternal anemia during pregnancy is associated with infant respiratory health outcomes. If this observation is replicated, maternal anemia may be a target for intervention and future research. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/21277514/Association_of_maternal_anemia_with_increased_wheeze_and_asthma_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)01058-6 DB - PRIME DP - Unbound Medicine ER -