TY - JOUR T1 - Association of maternal anemia with increased wheeze and asthma in children. AU - Triche,Elizabeth W, AU - Lundsberg,Lisbet S, AU - Wickner,Paige G, AU - Belanger,Kathleen, AU - Leaderer,Brian P, AU - Bracken,Michael B, Y1 - 2011/01/08/ PY - 2010/08/09/received PY - 2010/10/29/revised PY - 2010/11/05/accepted PY - 2011/2/1/entrez PY - 2011/2/1/pubmed PY - 2011/3/15/medline SP - 131 EP - 139.e1 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 106 IS - 2 N2 - BACKGROUND: Increasing interest has focused on maternal nutrition and micronutrient status during pregnancy and respiratory disease development in the offspring. OBJECTIVE: To examine the relationship between maternal anemia in pregnancy with wheeze and asthma in early childhood. METHODS: The cohort included children of women followed through pregnancy and recontacted when the child was 6 years of age to evaluate respiratory health. Exposure was assessed using maternal anemia diagnosis and hemoglobin (Hgb) < 11 during delivery hospitalization. Study outcomes include wheezing in early childhood; patterns of wheeze from birth to age 6 (early-onset transient wheeze; late-onset wheeze; early-onset persistent wheeze); and diagnosis of childhood asthma. RESULTS: Maternal anemia was reported by 11.9% of mothers and was associated with recurrent infant wheeze in the first year (adjusted odds ratio [ORa] = 2.17, 95% confidence interval [CI] 1.18, 4.00), wheezing before age 3 (Ora = 2.42, 95% CI 1.38, 4.23), and early-onset transient and early-onset persistent wheeze patterns (Ora = 2.81, 95%CI 1.38, 5.72, and Ora = 2.07, 95% CI 1.02, 4.22), respectively. Among children of mothers with asthma, maternal anemia was associated with recurrent wheeze in year 1 (Ora = 4.22, 95% CI 1.65, 10.80) and wheeze before age 3 (Ora = 2.73, 95% CI 1.17, 6.35). Offspring of mothers with asthma also had increased odds of asthma diagnosis (Ora = 2.53, 95% CI 1.04, 6.17) and current asthma (Ora = 3.46, 95% CI 1.45, 8.26). CONCLUSIONS: Maternal anemia during pregnancy is associated with infant respiratory health outcomes. If this observation is replicated, maternal anemia may be a target for intervention and future research. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/21277514/Association_of_maternal_anemia_with_increased_wheeze_and_asthma_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)01058-6 DB - PRIME DP - Unbound Medicine ER -