Citation
Horisawa, Tomoko, et al. "The Effects of Selective Antagonists of Serotonin 5-HT7 and 5-HT1A Receptors On MK-801-induced Impairment of Learning and Memory in the Passive Avoidance and Morris Water Maze Tests in Rats: Mechanistic Implications for the Beneficial Effects of the Novel Atypical Antipsychotic Lurasidone." Behavioural Brain Research, vol. 220, no. 1, 2011, pp. 83-90.
Horisawa T, Ishibashi T, Nishikawa H, et al. The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. Behav Brain Res. 2011;220(1):83-90.
Horisawa, T., Ishibashi, T., Nishikawa, H., Enomoto, T., Toma, S., Ishiyama, T., & Taiji, M. (2011). The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. Behavioural Brain Research, 220(1), 83-90. https://doi.org/10.1016/j.bbr.2011.01.034
Horisawa T, et al. The Effects of Selective Antagonists of Serotonin 5-HT7 and 5-HT1A Receptors On MK-801-induced Impairment of Learning and Memory in the Passive Avoidance and Morris Water Maze Tests in Rats: Mechanistic Implications for the Beneficial Effects of the Novel Atypical Antipsychotic Lurasidone. Behav Brain Res. 2011 Jun 20;220(1):83-90. PubMed PMID: 21277905.
TY - JOUR
T1 - The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone.
AU - Horisawa,Tomoko,
AU - Ishibashi,Tadashi,
AU - Nishikawa,Hiroyuki,
AU - Enomoto,Takeshi,
AU - Toma,Satoko,
AU - Ishiyama,Takeo,
AU - Taiji,Mutsuo,
Y1 - 2011/01/26/
PY - 2010/11/11/received
PY - 2011/01/14/revised
PY - 2011/01/19/accepted
PY - 2011/2/1/entrez
PY - 2011/2/1/pubmed
PY - 2011/7/16/medline
SP - 83
EP - 90
JF - Behavioural brain research
JO - Behav Brain Res
VL - 220
IS - 1
N2 - We have previously reported that lurasidone, a novel atypical antipsychotic with potent serotonin 5-HT(7) antagonist and 5-HT(1A) partial agonist activities, is superior to other antipsychotics in improving the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801-induced learning and memory impairment in the passive avoidance (PA) and Morris water maze (MWM) tests in rats. In this study, we investigated the effects of selective antagonists of 5-HT(7) and 5-HT(1A) receptors (SB-656104-A and WAY-100635, respectively) on MK-801-induced learning and memory impairment in the same tests. In the PA test, either pre-training (3 and 10mg/kg, p.o.) or post-training (0.3mg/kg, i.v.) administration of lurasidone significantly reversed the test response impaired by MK-801, consistent with our previous reports. Pre-training administration of either SB-656104-A (10 and 30 mg/kg, i.p.) or WAY-100635 (1mg/kg, s.c.) also significantly reversed MK-801-induced memory impairment. Furthermore, post-training administration of either SB-656104-A (0.3mg/kg, i.v.) or WAY-100635 (0.01 mg/kg, i.v.) counteracted the effect of MK-801, which suggested that both 5-HT receptor subtype-selective antagonists could restore the memory consolidation process. In the MWM test, SB-656104-A (3mg/kg, i.p.) reversed learning impairment induced by MK-801. On the other hand, WAY-100635 (0.3 and 1mg/kg, i.p.) did not have any effect on the MK-801-induced learning impairment. Taken together, our results showed that 5-HT(7) and 5-HT(1A) receptor antagonists mimic the effect of lurasidone in whole or in part, respectively, to reverse MK-801-induced learning and memory impairment, which warrants further investigation of the interaction of lurasidone with these serotonin receptors as a possible mechanism underlying its procognitive effects in these animal models.
SN - 1872-7549
UR - https://www.unboundmedicine.com/medline/citation/21277905/The_effects_of_selective_antagonists_of_serotonin_5_HT7_and_5_HT1A_receptors_on_MK_801_induced_impairment_of_learning_and_memory_in_the_passive_avoidance_and_Morris_water_maze_tests_in_rats:_mechanistic_implications_for_the_beneficial_effects_of_the_novel_atypical_antipsychotic_lurasidone_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(11)00074-X
DB - PRIME
DP - Unbound Medicine
ER -