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Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.
Nat Neurosci. 2011 Mar; 14(3):345-50.NN

Abstract

The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins. Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets.

Authors+Show Affiliations

INSERM U862, Physiopathology of Synaptic Plasticity Group, Neurocentre Magendie, Bordeaux Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21278728

Citation

Lafourcade, Mathieu, et al. "Nutritional Omega-3 Deficiency Abolishes Endocannabinoid-mediated Neuronal Functions." Nature Neuroscience, vol. 14, no. 3, 2011, pp. 345-50.
Lafourcade M, Larrieu T, Mato S, et al. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci. 2011;14(3):345-50.
Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A., Sepers, M., Matias, I., De Smedt-Peyrusse, V., Labrousse, V. F., Bretillon, L., Matute, C., Rodríguez-Puertas, R., Layé, S., & Manzoni, O. J. (2011). Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nature Neuroscience, 14(3), 345-50. https://doi.org/10.1038/nn.2736
Lafourcade M, et al. Nutritional Omega-3 Deficiency Abolishes Endocannabinoid-mediated Neuronal Functions. Nat Neurosci. 2011;14(3):345-50. PubMed PMID: 21278728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. AU - Lafourcade,Mathieu, AU - Larrieu,Thomas, AU - Mato,Susana, AU - Duffaud,Anais, AU - Sepers,Marja, AU - Matias,Isabelle, AU - De Smedt-Peyrusse,Veronique, AU - Labrousse,Virginie F, AU - Bretillon,Lionel, AU - Matute,Carlos, AU - Rodríguez-Puertas,Rafael, AU - Layé,Sophie, AU - Manzoni,Olivier J, Y1 - 2011/01/30/ PY - 2010/10/01/received PY - 2010/12/15/accepted PY - 2011/2/1/entrez PY - 2011/2/1/pubmed PY - 2011/4/16/medline SP - 345 EP - 50 JF - Nature neuroscience JO - Nat Neurosci VL - 14 IS - 3 N2 - The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins. Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets. SN - 1546-1726 UR - https://www.unboundmedicine.com/medline/citation/21278728/abstract/Nutritional_omega_3_deficiency_abolishes_endocannabinoid_mediated_neuronal_functions_ L2 - https://doi.org/10.1038/nn.2736 DB - PRIME DP - Unbound Medicine ER -