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Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.

Abstract

The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins. Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets.

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  • Authors+Show Affiliations

    ,

    INSERM U862, Physiopathology of Synaptic Plasticity Group, Neurocentre Magendie, Bordeaux Cedex, France.

    , , , , , , , , , , ,

    Source

    Nature neuroscience 14:3 2011 Mar pg 345-50

    MeSH

    Animals
    Behavior, Animal
    Cannabinoid Receptor Modulators
    Diet
    Emotions
    Endocannabinoids
    Fatty Acids, Omega-3
    Female
    Humans
    Malnutrition
    Mice
    Mice, Inbred C57BL
    Neuronal Plasticity
    Neurons
    Nucleus Accumbens
    Prefrontal Cortex
    Receptor, Cannabinoid, CB1
    Synapses

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21278728

    Citation

    Lafourcade, Mathieu, et al. "Nutritional Omega-3 Deficiency Abolishes Endocannabinoid-mediated Neuronal Functions." Nature Neuroscience, vol. 14, no. 3, 2011, pp. 345-50.
    Lafourcade M, Larrieu T, Mato S, et al. Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nat Neurosci. 2011;14(3):345-50.
    Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A., Sepers, M., Matias, I., ... Manzoni, O. J. (2011). Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nature Neuroscience, 14(3), pp. 345-50. doi:10.1038/nn.2736.
    Lafourcade M, et al. Nutritional Omega-3 Deficiency Abolishes Endocannabinoid-mediated Neuronal Functions. Nat Neurosci. 2011;14(3):345-50. PubMed PMID: 21278728.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. AU - Lafourcade,Mathieu, AU - Larrieu,Thomas, AU - Mato,Susana, AU - Duffaud,Anais, AU - Sepers,Marja, AU - Matias,Isabelle, AU - De Smedt-Peyrusse,Veronique, AU - Labrousse,Virginie F, AU - Bretillon,Lionel, AU - Matute,Carlos, AU - Rodríguez-Puertas,Rafael, AU - Layé,Sophie, AU - Manzoni,Olivier J, Y1 - 2011/01/30/ PY - 2010/10/01/received PY - 2010/12/15/accepted PY - 2011/2/1/entrez PY - 2011/2/1/pubmed PY - 2011/4/16/medline SP - 345 EP - 50 JF - Nature neuroscience JO - Nat. Neurosci. VL - 14 IS - 3 N2 - The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins. Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets. SN - 1546-1726 UR - https://www.unboundmedicine.com/medline/citation/21278728/abstract/Nutritional_omega_3_deficiency_abolishes_endocannabinoid_mediated_neuronal_functions_ L2 - http://dx.doi.org/10.1038/nn.2736 DB - PRIME DP - Unbound Medicine ER -