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Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components.
Environ Sci Technol. 2011 Mar 01; 45(5):1977-83.ES

Abstract

Water chemistry can be a major factor regulating the toxicity mechanism of ZnO nanoparticles (nano-ZnO) in water. The effect of five commonly used aqueous media with various chemical properties on the toxicity of nano-ZnO to Escherichia coli O111 (E. coli) was investigated, including ultrapure water, 0.85% NaCl, phosphate-buffered saline (PBS), minimal Davis (MD), and Luria-Bertani (LB). Combined results of physicochemical characterization and antibacterial tests of nano-ZnO in the five media suggest that the toxicity of nano-ZnO is mainly due to the free zinc ions and labile zinc complexes. The toxicity of nano-ZnO in the five media deceased as follows: ultrapure water > NaCl > MD > LB > PBS. The generation of precipitates (Zn(3)(PO(4))(2) in PBS) and zinc complexes (of zinc with citrate and amino acids in MD and LB, respectively) dramatically decreased the concentration of Zn(2+) ions, resulting in the lower toxicity in these media. Additionally, the isotonic and rich nutrient conditions improved the tolerance of E. coli to toxicants. Considering the dramatic difference of the toxicity of nano-ZnO in various aqueous media, the effect of water chemistry on the physicochemical properties of nanoparticles should be paid more attention in future nanotoxicity evaluations.

Authors+Show Affiliations

Department of Environmental Science, Zhejiang University, Hangzhou 310058, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21280647

Citation

Li, Mei, et al. "Toxicity of ZnO Nanoparticles to Escherichia Coli: Mechanism and the Influence of Medium Components." Environmental Science & Technology, vol. 45, no. 5, 2011, pp. 1977-83.
Li M, Zhu L, Lin D. Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components. Environ Sci Technol. 2011;45(5):1977-83.
Li, M., Zhu, L., & Lin, D. (2011). Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components. Environmental Science & Technology, 45(5), 1977-83. https://doi.org/10.1021/es102624t
Li M, Zhu L, Lin D. Toxicity of ZnO Nanoparticles to Escherichia Coli: Mechanism and the Influence of Medium Components. Environ Sci Technol. 2011 Mar 1;45(5):1977-83. PubMed PMID: 21280647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity of ZnO nanoparticles to Escherichia coli: mechanism and the influence of medium components. AU - Li,Mei, AU - Zhu,Lizhong, AU - Lin,Daohui, Y1 - 2011/01/31/ PY - 2011/2/2/entrez PY - 2011/2/2/pubmed PY - 2011/6/7/medline SP - 1977 EP - 83 JF - Environmental science & technology JO - Environ Sci Technol VL - 45 IS - 5 N2 - Water chemistry can be a major factor regulating the toxicity mechanism of ZnO nanoparticles (nano-ZnO) in water. The effect of five commonly used aqueous media with various chemical properties on the toxicity of nano-ZnO to Escherichia coli O111 (E. coli) was investigated, including ultrapure water, 0.85% NaCl, phosphate-buffered saline (PBS), minimal Davis (MD), and Luria-Bertani (LB). Combined results of physicochemical characterization and antibacterial tests of nano-ZnO in the five media suggest that the toxicity of nano-ZnO is mainly due to the free zinc ions and labile zinc complexes. The toxicity of nano-ZnO in the five media deceased as follows: ultrapure water > NaCl > MD > LB > PBS. The generation of precipitates (Zn(3)(PO(4))(2) in PBS) and zinc complexes (of zinc with citrate and amino acids in MD and LB, respectively) dramatically decreased the concentration of Zn(2+) ions, resulting in the lower toxicity in these media. Additionally, the isotonic and rich nutrient conditions improved the tolerance of E. coli to toxicants. Considering the dramatic difference of the toxicity of nano-ZnO in various aqueous media, the effect of water chemistry on the physicochemical properties of nanoparticles should be paid more attention in future nanotoxicity evaluations. SN - 1520-5851 UR - https://www.unboundmedicine.com/medline/citation/21280647/Toxicity_of_ZnO_nanoparticles_to_Escherichia_coli:_mechanism_and_the_influence_of_medium_components_ L2 - https://doi.org/10.1021/es102624t DB - PRIME DP - Unbound Medicine ER -