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Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex.
Brain Res 2011; 1382:230-7BR

Abstract

Marijuana (Cannabis sativa) is one of the most widely used illicit drugs in the world. Its use is associated with impairments in cognitive function. We previously reported that Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the primary psychoactive component of marijuana, impaired spatial working memory in the radial maze task when injected intracortically (IC) into the medial prefrontal cortex (mPFC) of rats. Here, we used this paradigm to evaluate the involvement of prefrontal dopamine receptors in working memory disruption induced by Δ(9)-THC. Intracortical pre-treatment of animals with either the D(1)- or D(2)-like dopamine receptor antagonists SCH 23390 or clozapine, respectively, significantly reduced the number of errors rats made in the radial maze following treatment with Δ(9)-THC also administered intracortically. These results were obtained in the absence of locomotor impairment, as evidenced by the time spent in each arm a rat visited. Our findings suggest that prefrontal dopamine receptors are involved in Δ(9)-THC-induced disruption of spatial working memory. This interaction between the cannabinoid system and dopamine release in the PFC contributes to new directions in research and to treatments for cognitive dysfunctions associated with drug abuse and dependence.

Authors+Show Affiliations

Federal University of Espirito Santo, Vitória, ES, Brazil. susuvi@terra.com.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21281616

Citation

Rodrigues, Lívia Carla de Melo, et al. "Clozapine and SCH 23390 Prevent the Spatial Working Memory Disruption Induced By Δ9-THC Administration Into the Medial Prefrontal Cortex." Brain Research, vol. 1382, 2011, pp. 230-7.
Rodrigues LC, Conti CL, Nakamura-Palacios EM. Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex. Brain Res. 2011;1382:230-7.
Rodrigues, L. C., Conti, C. L., & Nakamura-Palacios, E. M. (2011). Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex. Brain Research, 1382, pp. 230-7. doi:10.1016/j.brainres.2011.01.069.
Rodrigues LC, Conti CL, Nakamura-Palacios EM. Clozapine and SCH 23390 Prevent the Spatial Working Memory Disruption Induced By Δ9-THC Administration Into the Medial Prefrontal Cortex. Brain Res. 2011 Mar 25;1382:230-7. PubMed PMID: 21281616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clozapine and SCH 23390 prevent the spatial working memory disruption induced by Δ9-THC administration into the medial prefrontal cortex. AU - Rodrigues,Lívia Carla de Melo, AU - Conti,Catarine Lima, AU - Nakamura-Palacios,Ester Miyuki, Y1 - 2011/01/28/ PY - 2010/10/11/received PY - 2011/01/18/revised PY - 2011/01/20/accepted PY - 2011/2/2/entrez PY - 2011/2/2/pubmed PY - 2011/11/16/medline SP - 230 EP - 7 JF - Brain research JO - Brain Res. VL - 1382 N2 - Marijuana (Cannabis sativa) is one of the most widely used illicit drugs in the world. Its use is associated with impairments in cognitive function. We previously reported that Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the primary psychoactive component of marijuana, impaired spatial working memory in the radial maze task when injected intracortically (IC) into the medial prefrontal cortex (mPFC) of rats. Here, we used this paradigm to evaluate the involvement of prefrontal dopamine receptors in working memory disruption induced by Δ(9)-THC. Intracortical pre-treatment of animals with either the D(1)- or D(2)-like dopamine receptor antagonists SCH 23390 or clozapine, respectively, significantly reduced the number of errors rats made in the radial maze following treatment with Δ(9)-THC also administered intracortically. These results were obtained in the absence of locomotor impairment, as evidenced by the time spent in each arm a rat visited. Our findings suggest that prefrontal dopamine receptors are involved in Δ(9)-THC-induced disruption of spatial working memory. This interaction between the cannabinoid system and dopamine release in the PFC contributes to new directions in research and to treatments for cognitive dysfunctions associated with drug abuse and dependence. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/21281616/abstract/Clozapine_and_SCH_23390_pr L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(11)00153-3 DB - PRIME DP - Unbound Medicine ER -