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Exercise training increases size of hippocampus and improves memory.
Proc Natl Acad Sci U S A 2011; 108(7):3017-22PN

Abstract

The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults, and physical activity training increases hippocampal perfusion, but the extent to which aerobic exercise training can modify hippocampal volume in late adulthood remains unknown. Here we show, in a randomized controlled trial with 120 older adults, that aerobic exercise training increases the size of the anterior hippocampus, leading to improvements in spatial memory. Exercise training increased hippocampal volume by 2%, effectively reversing age-related loss in volume by 1 to 2 y. We also demonstrate that increased hippocampal volume is associated with greater serum levels of BDNF, a mediator of neurogenesis in the dentate gyrus. Hippocampal volume declined in the control group, but higher preintervention fitness partially attenuated the decline, suggesting that fitness protects against volume loss. Caudate nucleus and thalamus volumes were unaffected by the intervention. These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function.

Authors+Show Affiliations

Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21282661

Citation

Erickson, Kirk I., et al. "Exercise Training Increases Size of Hippocampus and Improves Memory." Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 7, 2011, pp. 3017-22.
Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA. 2011;108(7):3017-22.
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., ... Kramer, A. F. (2011). Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America, 108(7), pp. 3017-22. doi:10.1073/pnas.1015950108.
Erickson KI, et al. Exercise Training Increases Size of Hippocampus and Improves Memory. Proc Natl Acad Sci USA. 2011 Feb 15;108(7):3017-22. PubMed PMID: 21282661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise training increases size of hippocampus and improves memory. AU - Erickson,Kirk I, AU - Voss,Michelle W, AU - Prakash,Ruchika Shaurya, AU - Basak,Chandramallika, AU - Szabo,Amanda, AU - Chaddock,Laura, AU - Kim,Jennifer S, AU - Heo,Susie, AU - Alves,Heloisa, AU - White,Siobhan M, AU - Wojcicki,Thomas R, AU - Mailey,Emily, AU - Vieira,Victoria J, AU - Martin,Stephen A, AU - Pence,Brandt D, AU - Woods,Jeffrey A, AU - McAuley,Edward, AU - Kramer,Arthur F, Y1 - 2011/01/31/ PY - 2011/2/2/entrez PY - 2011/2/2/pubmed PY - 2011/4/16/medline SP - 3017 EP - 22 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 108 IS - 7 N2 - The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. Hippocampal and medial temporal lobe volumes are larger in higher-fit adults, and physical activity training increases hippocampal perfusion, but the extent to which aerobic exercise training can modify hippocampal volume in late adulthood remains unknown. Here we show, in a randomized controlled trial with 120 older adults, that aerobic exercise training increases the size of the anterior hippocampus, leading to improvements in spatial memory. Exercise training increased hippocampal volume by 2%, effectively reversing age-related loss in volume by 1 to 2 y. We also demonstrate that increased hippocampal volume is associated with greater serum levels of BDNF, a mediator of neurogenesis in the dentate gyrus. Hippocampal volume declined in the control group, but higher preintervention fitness partially attenuated the decline, suggesting that fitness protects against volume loss. Caudate nucleus and thalamus volumes were unaffected by the intervention. These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/21282661/Exercise_training_increases_size_of_hippocampus_and_improves_memory_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=21282661 DB - PRIME DP - Unbound Medicine ER -