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Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: a case-control polysomnography-based study.
Mov Disord. 2011 Feb 01; 26(2):234-40.MD

Abstract

OBJECTIVES

To study heart rate variability during nocturnal sleep in idiopathic Parkinson's disease.

METHODS

Retrospective study, using part of the data set accumulated in an earlier study, in which polysomnography was performed in 35 idiopathic Parkinson's disease patients under their usual medication and in 35 non-idiopathic Parkinson's disease controls, matched for age, gender, and amount of apneas/hypopneas per hour. R-R intervals were calculated separately for non-rapid eye movements and rapid eye movements sleep stages. R-R variability was analyzed for time and frequency domains. Selected variables considered were high frequency band (0.15-0.40 Hz) influenced by parasympathetic input and low frequency band (0.04-0.15 Hz) influenced by sympathetic input. Both frequency bands were considered in normalized units (low frequency and high frequency normalized units). Low frequency/high frequency ratio was calculated as an estimate of sympathicovagal balance.

RESULTS

All respiratory and sleep stage characteristics were similar in both groups. Low frequency normalized unit was reduced in idiopathic Parkinson's disease patients, both for non-rapid eye movements and rapid eye movements sleep (P = 0.005). Low frequency/high frequency was smaller in idiopathic Parkinson's disease for both sleep portions (P = 0.02).

CONCLUSIONS

Idiopathic Parkinson's disease patients show reduced sympathetic influence on heart rate variability in both non-rapid eye movements and rapid eye movements sleep stages. We speculate that these findings are a consequence of the postganglionic noradrenergic cardiac denervation found in idiopathic Parkinson's disease patients.

Authors+Show Affiliations

Centre de Recherche Publique Santé, Centre d'Etudes en Santé, Strassen, Luxembourg.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21284038

Citation

Sauvageot, Nicolas, et al. "Reduced Sympathetically Driven Heart Rate Variability During Sleep in Parkinson's Disease: a Case-control Polysomnography-based Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 26, no. 2, 2011, pp. 234-40.
Sauvageot N, Vaillant M, Diederich NJ. Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: a case-control polysomnography-based study. Mov Disord. 2011;26(2):234-40.
Sauvageot, N., Vaillant, M., & Diederich, N. J. (2011). Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: a case-control polysomnography-based study. Movement Disorders : Official Journal of the Movement Disorder Society, 26(2), 234-40. https://doi.org/10.1002/mds.23479
Sauvageot N, Vaillant M, Diederich NJ. Reduced Sympathetically Driven Heart Rate Variability During Sleep in Parkinson's Disease: a Case-control Polysomnography-based Study. Mov Disord. 2011 Feb 1;26(2):234-40. PubMed PMID: 21284038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: a case-control polysomnography-based study. AU - Sauvageot,Nicolas, AU - Vaillant,Michel, AU - Diederich,Nico J, Y1 - 2011/01/31/ PY - 2010/04/08/received PY - 2010/07/19/revised PY - 2010/09/21/accepted PY - 2011/2/2/entrez PY - 2011/2/2/pubmed PY - 2011/7/26/medline SP - 234 EP - 40 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 26 IS - 2 N2 - OBJECTIVES: To study heart rate variability during nocturnal sleep in idiopathic Parkinson's disease. METHODS: Retrospective study, using part of the data set accumulated in an earlier study, in which polysomnography was performed in 35 idiopathic Parkinson's disease patients under their usual medication and in 35 non-idiopathic Parkinson's disease controls, matched for age, gender, and amount of apneas/hypopneas per hour. R-R intervals were calculated separately for non-rapid eye movements and rapid eye movements sleep stages. R-R variability was analyzed for time and frequency domains. Selected variables considered were high frequency band (0.15-0.40 Hz) influenced by parasympathetic input and low frequency band (0.04-0.15 Hz) influenced by sympathetic input. Both frequency bands were considered in normalized units (low frequency and high frequency normalized units). Low frequency/high frequency ratio was calculated as an estimate of sympathicovagal balance. RESULTS: All respiratory and sleep stage characteristics were similar in both groups. Low frequency normalized unit was reduced in idiopathic Parkinson's disease patients, both for non-rapid eye movements and rapid eye movements sleep (P = 0.005). Low frequency/high frequency was smaller in idiopathic Parkinson's disease for both sleep portions (P = 0.02). CONCLUSIONS: Idiopathic Parkinson's disease patients show reduced sympathetic influence on heart rate variability in both non-rapid eye movements and rapid eye movements sleep stages. We speculate that these findings are a consequence of the postganglionic noradrenergic cardiac denervation found in idiopathic Parkinson's disease patients. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/21284038/Reduced_sympathetically_driven_heart_rate_variability_during_sleep_in_Parkinson's_disease:_a_case_control_polysomnography_based_study_ L2 - https://doi.org/10.1002/mds.23479 DB - PRIME DP - Unbound Medicine ER -