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Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats.
Eur Rev Med Pharmacol Sci. 2010 Nov; 14(11):903-14.ER

Abstract

BACKGROUND AND OBJECTIVES

The aim of the present study was to determine if the combination therapy of quercetin along with vitamins (C and E) has any advantage over the cadmium (Cd) induced oxidative stress and renal injury in rats. They were analysed serum and urinary markers of renal damage (urea, uric acid, creatinine and creatinine clearance), renal oxidative stress indices (thio barbituric acid reactive substances: TBARS, lipid hydroperoxides (LOOH) and protein carbonyls (PC), renal non-enzymatic [reduced glutathione (GSH), total sulphydryl groups (TSH)], vitamin-C and vitamin-E, enzymatic [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-s-transferase, GST)], glutathione metabolizing enzymes [glutathione reductase (GR) and glucose-6-phosphate dehydrogenase, (G6PD)] and histological changes in kidney.

RESULTS

Cd intoxication significantly (P > 0.05) increased the levels of serum nephritic markers (urea, uric acid, creatinine) and significantly (P > 0.05) reduced the urea, uric acid and creatinine in urine and serum creatinine clearance. It also significantly (P > 0.05) increased renal oxidative stress markers and significantly (P > 0.05) decreased renal non-enzymatic and enzymatic antioxidants status and severely increased the histo-pathological changes when compared to normal control rats. Cd intoxicated rats pre-treated with quercetin (QE) alone and QE along with vitamin-C (VC) and vitamin-E (VE) significantly ameliorated Cd induced anomalies in renal biochemical and histological indices.

CONCLUSION

The ameliorative effect against Cd intoxication was much pronounced in rats treated with QE along with vitamins C and E.

Authors+Show Affiliations

Department of Zoology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India. smprabu73@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21284339

Citation

Milton Prabu, S, et al. "Quercetin in Combination With Vitamins (C and E) Improves Oxidative Stress and Renal Injury in Cadmium Intoxicated Rats." European Review for Medical and Pharmacological Sciences, vol. 14, no. 11, 2010, pp. 903-14.
Milton Prabu S, Shagirtha K, Renugadevi J. Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats. Eur Rev Med Pharmacol Sci. 2010;14(11):903-14.
Milton Prabu, S., Shagirtha, K., & Renugadevi, J. (2010). Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats. European Review for Medical and Pharmacological Sciences, 14(11), 903-14.
Milton Prabu S, Shagirtha K, Renugadevi J. Quercetin in Combination With Vitamins (C and E) Improves Oxidative Stress and Renal Injury in Cadmium Intoxicated Rats. Eur Rev Med Pharmacol Sci. 2010;14(11):903-14. PubMed PMID: 21284339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats. AU - Milton Prabu,S, AU - Shagirtha,K, AU - Renugadevi,J, PY - 2011/2/3/entrez PY - 2011/2/3/pubmed PY - 2011/2/25/medline SP - 903 EP - 14 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 14 IS - 11 N2 - BACKGROUND AND OBJECTIVES: The aim of the present study was to determine if the combination therapy of quercetin along with vitamins (C and E) has any advantage over the cadmium (Cd) induced oxidative stress and renal injury in rats. They were analysed serum and urinary markers of renal damage (urea, uric acid, creatinine and creatinine clearance), renal oxidative stress indices (thio barbituric acid reactive substances: TBARS, lipid hydroperoxides (LOOH) and protein carbonyls (PC), renal non-enzymatic [reduced glutathione (GSH), total sulphydryl groups (TSH)], vitamin-C and vitamin-E, enzymatic [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione-s-transferase, GST)], glutathione metabolizing enzymes [glutathione reductase (GR) and glucose-6-phosphate dehydrogenase, (G6PD)] and histological changes in kidney. RESULTS: Cd intoxication significantly (P > 0.05) increased the levels of serum nephritic markers (urea, uric acid, creatinine) and significantly (P > 0.05) reduced the urea, uric acid and creatinine in urine and serum creatinine clearance. It also significantly (P > 0.05) increased renal oxidative stress markers and significantly (P > 0.05) decreased renal non-enzymatic and enzymatic antioxidants status and severely increased the histo-pathological changes when compared to normal control rats. Cd intoxicated rats pre-treated with quercetin (QE) alone and QE along with vitamin-C (VC) and vitamin-E (VE) significantly ameliorated Cd induced anomalies in renal biochemical and histological indices. CONCLUSION: The ameliorative effect against Cd intoxication was much pronounced in rats treated with QE along with vitamins C and E. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/21284339/Quercetin_in_combination_with_vitamins__C_and_E__improves_oxidative_stress_and_renal_injury_in_cadmium_intoxicated_rats_ L2 - https://medlineplus.gov/vitaminc.html DB - PRIME DP - Unbound Medicine ER -