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Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume.
Psychol Med. 2011 Sep; 41(9):1997-2006.PM

Abstract

BACKGROUND

The apolipoprotein E4 allele (ApoE4) is an established genetic risk factor for Alzheimer's disease (AD). However, its effects on cognitive performance and brain structure in healthy individuals are complex. We investigated the effect of ApoE4 on cognitive performance and medial temporal lobe volumetric measures in cognitively unimpaired young elderly with and without subjective memory impairment (SMI), which is an at-risk condition for dementia.MethodAltogether, 40 individuals with SMI and 62 without were tested on episodic memory and on tasks of speed and executive function. All participants were ApoE genotyped. 21 subjects with SMI and 47 without received additional structural magnetic resonance imaging. Volumetric measures of the hippocampus, the entorhinal cortex and the amygdala were obtained manually.

RESULTS

In the SMI group, ApoE4 carriers performed worse on the episodic memory (p=0.049) and showed smaller left hippocampal volumes (p=0.030). In the individuals without SMI, the ApoE4 carriers performed better on episodic memory (p=0.018) and had larger right hippocampal volumes (p=0.039). The interaction of group (SMI/no SMI) and ApoE genotype was significant for episodic memory (p=0.005) and right and left hippocampal volumes (p=0.042; p=0.035). There were no within-group differences or interaction effects on speed and executive function composite measures or other volumetric measures.

CONCLUSIONS

The negative effect of ApoE4 on episodic memory and hippocampal volume in SMI supports SMI as a prodromal condition of AD. The positive effects of ApoE4 in subjects without SMI adds to a number of reports on positive ApoE4 effects in young and very old individuals.

Authors+Show Affiliations

Department of Psychiatry, University of Bonn, Bonn, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21284913

Citation

Striepens, N, et al. "Interaction Effects of Subjective Memory Impairment and ApoE4 Genotype On Episodic Memory and Hippocampal Volume." Psychological Medicine, vol. 41, no. 9, 2011, pp. 1997-2006.
Striepens N, Scheef L, Wind A, et al. Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume. Psychol Med. 2011;41(9):1997-2006.
Striepens, N., Scheef, L., Wind, A., Meiberth, D., Popp, J., Spottke, A., Kölsch, H., Wagner, M., & Jessen, F. (2011). Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume. Psychological Medicine, 41(9), 1997-2006. https://doi.org/10.1017/S0033291711000067
Striepens N, et al. Interaction Effects of Subjective Memory Impairment and ApoE4 Genotype On Episodic Memory and Hippocampal Volume. Psychol Med. 2011;41(9):1997-2006. PubMed PMID: 21284913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume. AU - Striepens,N, AU - Scheef,L, AU - Wind,A, AU - Meiberth,D, AU - Popp,J, AU - Spottke,A, AU - Kölsch,H, AU - Wagner,M, AU - Jessen,F, Y1 - 2011/02/02/ PY - 2011/2/3/entrez PY - 2011/2/3/pubmed PY - 2012/2/3/medline SP - 1997 EP - 2006 JF - Psychological medicine JO - Psychol Med VL - 41 IS - 9 N2 - BACKGROUND: The apolipoprotein E4 allele (ApoE4) is an established genetic risk factor for Alzheimer's disease (AD). However, its effects on cognitive performance and brain structure in healthy individuals are complex. We investigated the effect of ApoE4 on cognitive performance and medial temporal lobe volumetric measures in cognitively unimpaired young elderly with and without subjective memory impairment (SMI), which is an at-risk condition for dementia.MethodAltogether, 40 individuals with SMI and 62 without were tested on episodic memory and on tasks of speed and executive function. All participants were ApoE genotyped. 21 subjects with SMI and 47 without received additional structural magnetic resonance imaging. Volumetric measures of the hippocampus, the entorhinal cortex and the amygdala were obtained manually. RESULTS: In the SMI group, ApoE4 carriers performed worse on the episodic memory (p=0.049) and showed smaller left hippocampal volumes (p=0.030). In the individuals without SMI, the ApoE4 carriers performed better on episodic memory (p=0.018) and had larger right hippocampal volumes (p=0.039). The interaction of group (SMI/no SMI) and ApoE genotype was significant for episodic memory (p=0.005) and right and left hippocampal volumes (p=0.042; p=0.035). There were no within-group differences or interaction effects on speed and executive function composite measures or other volumetric measures. CONCLUSIONS: The negative effect of ApoE4 on episodic memory and hippocampal volume in SMI supports SMI as a prodromal condition of AD. The positive effects of ApoE4 in subjects without SMI adds to a number of reports on positive ApoE4 effects in young and very old individuals. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/21284913/Interaction_effects_of_subjective_memory_impairment_and_ApoE4_genotype_on_episodic_memory_and_hippocampal_volume_ L2 - https://www.cambridge.org/core/product/identifier/S0033291711000067/type/journal_article DB - PRIME DP - Unbound Medicine ER -