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Asymmetry of salivary cortisol and α-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa.
Psychol Med. 2011 Sep; 41(9):1963-9.PM

Abstract

BACKGROUND

The stress response involves the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). As a role for stress in determining of the onset and the natural course of eating disorders (EDs) has been proposed, the study of the psychobiology of the stress response in patients with anorexia nervosa (AN) and bulimia nervosa (BN) should be helpful in understanding the pathophysiology of these disorders. The two neurobiological components of the stress response can be easily explored in humans by the measurement of salivary cortisol and α-amylase response to a stressor. Therefore, we assessed salivary cortisol and α-amylase responses to the Trier Social Stress Test (TSST) in symptomatic patients with AN and BN compared to healthy controls.

METHOD

Seven AN women, eight BN women and eight age-matched healthy females underwent the TSST between 1530 and 1700 h. Salivary cortisol and α-amylase levels were measured by an enzyme-linked immunosorbent assay (ELISA).

RESULTS

Compared to healthy women, AN patients showed a normal cortisol response to the TSST, although this occurred at significantly increased hormone levels, and an almost complete absence of response of α-amylase. BN women, however, exhibited enhanced pre-stress levels of salivary α-amylase but a normal response of the enzyme and cortisol to the TSST.

CONCLUSIONS

These findings demonstrate, for the first time, the occurrence of an asymmetry between the HPA axis and SNS components of the stress response in the acute phase of AN but not in BN. The pathophysiological significance of this asymmetry remains to be determined.

Authors+Show Affiliations

Department of Psychiatry, University of Naples SUN, Italy. monteri@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21284914

Citation

Monteleone, P, et al. "Asymmetry of Salivary Cortisol and Α-amylase Responses to Psychosocial Stress in Anorexia Nervosa but Not in Bulimia Nervosa." Psychological Medicine, vol. 41, no. 9, 2011, pp. 1963-9.
Monteleone P, Scognamiglio P, Canestrelli B, et al. Asymmetry of salivary cortisol and α-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa. Psychol Med. 2011;41(9):1963-9.
Monteleone, P., Scognamiglio, P., Canestrelli, B., Serino, I., Monteleone, A. M., & Maj, M. (2011). Asymmetry of salivary cortisol and α-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa. Psychological Medicine, 41(9), 1963-9. https://doi.org/10.1017/S0033291711000092
Monteleone P, et al. Asymmetry of Salivary Cortisol and Α-amylase Responses to Psychosocial Stress in Anorexia Nervosa but Not in Bulimia Nervosa. Psychol Med. 2011;41(9):1963-9. PubMed PMID: 21284914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymmetry of salivary cortisol and α-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa. AU - Monteleone,P, AU - Scognamiglio,P, AU - Canestrelli,B, AU - Serino,I, AU - Monteleone,A M, AU - Maj,M, Y1 - 2011/02/02/ PY - 2011/2/3/entrez PY - 2011/2/3/pubmed PY - 2012/2/3/medline SP - 1963 EP - 9 JF - Psychological medicine JO - Psychol Med VL - 41 IS - 9 N2 - BACKGROUND: The stress response involves the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). As a role for stress in determining of the onset and the natural course of eating disorders (EDs) has been proposed, the study of the psychobiology of the stress response in patients with anorexia nervosa (AN) and bulimia nervosa (BN) should be helpful in understanding the pathophysiology of these disorders. The two neurobiological components of the stress response can be easily explored in humans by the measurement of salivary cortisol and α-amylase response to a stressor. Therefore, we assessed salivary cortisol and α-amylase responses to the Trier Social Stress Test (TSST) in symptomatic patients with AN and BN compared to healthy controls. METHOD: Seven AN women, eight BN women and eight age-matched healthy females underwent the TSST between 1530 and 1700 h. Salivary cortisol and α-amylase levels were measured by an enzyme-linked immunosorbent assay (ELISA). RESULTS: Compared to healthy women, AN patients showed a normal cortisol response to the TSST, although this occurred at significantly increased hormone levels, and an almost complete absence of response of α-amylase. BN women, however, exhibited enhanced pre-stress levels of salivary α-amylase but a normal response of the enzyme and cortisol to the TSST. CONCLUSIONS: These findings demonstrate, for the first time, the occurrence of an asymmetry between the HPA axis and SNS components of the stress response in the acute phase of AN but not in BN. The pathophysiological significance of this asymmetry remains to be determined. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/21284914/Asymmetry_of_salivary_cortisol_and_α_amylase_responses_to_psychosocial_stress_in_anorexia_nervosa_but_not_in_bulimia_nervosa_ L2 - https://www.cambridge.org/core/product/identifier/S0033291711000092/type/journal_article DB - PRIME DP - Unbound Medicine ER -