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Autonomic response to periodic leg movements during sleep in narcolepsy-cataplexy.
Sleep. 2011 Feb 01; 34(2):219-23.S

Abstract

STUDY OBJECTIVES

To test the hypothesis of autonomic nervous system dysfunction in patients with narcolepsy-cataplexy (NC) by assessing the physiologic activations associated with periodic limb movements during sleep (PLMS).

DESIGN

Sleep and heart rate (HR) were recorded during 1 night of polysomnography.

SETTING

Data were collected at the Sleep Disorders Center, Sacre-Coeur Hospital, Montreal, Canada.

PARTICIPANTS

Data from 14 patients with NC (6 men, 8 women, mean age: 52.5 ± 11.9 years) were compared with data from 14 healthy control subjects matched for age and sex.

INTERVENTIONS

NA.

MEASUREMENTS AND RESULTS

Analyses included sleep stages, PLMS, microarousals, RR intervals converted into beats per minute on segments lasting 25 heartbeats (10 RR intervals before PLMS and 15 after), and cardiac-activation amplitudes. A Group-by-Heartbeat interaction was noted for PLMS without microarousals; the patients had a tachycardia of lower amplitude and a delayed and lower-amplitude bradycardia, compared with normal control subjects. Similar significant HR modifications were observed for PLMS with microarousals between patients with NC and control subjects. Patients with NC had a reduced magnitude of cardiac activation associated with PLMS with and without microarousals, as compared with control subjects. A negative correlation was noted between cardiac-activation amplitude and age in patients with NC, but no correlation with PLMS index was found in either patients with NC or control subjects.

CONCLUSION

A significant reduction in the amplitude of PLMS-related HR responses in both tachycardia and bradycardia was found in patients with NC. These findings favor the physiologic relevance of the action of hypocretin on autonomic function that may be of clinical significance, i.e., increasing the risk of cardiovascular diseases.

Authors+Show Affiliations

Department of Neurology, National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Hôpital Gui de Chauliac, INSERM U888, Montpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21286243

Citation

Dauvilliers, Yves, et al. "Autonomic Response to Periodic Leg Movements During Sleep in Narcolepsy-cataplexy." Sleep, vol. 34, no. 2, 2011, pp. 219-23.
Dauvilliers Y, Pennestri MH, Whittom S, et al. Autonomic response to periodic leg movements during sleep in narcolepsy-cataplexy. Sleep. 2011;34(2):219-23.
Dauvilliers, Y., Pennestri, M. H., Whittom, S., Lanfranchi, P. A., & Montplaisir, J. Y. (2011). Autonomic response to periodic leg movements during sleep in narcolepsy-cataplexy. Sleep, 34(2), 219-23.
Dauvilliers Y, et al. Autonomic Response to Periodic Leg Movements During Sleep in Narcolepsy-cataplexy. Sleep. 2011 Feb 1;34(2):219-23. PubMed PMID: 21286243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic response to periodic leg movements during sleep in narcolepsy-cataplexy. AU - Dauvilliers,Yves, AU - Pennestri,Marie-Hélène, AU - Whittom,Shirley, AU - Lanfranchi,Paola A, AU - Montplaisir,Jacques Y, Y1 - 2011/02/01/ PY - 2011/2/3/entrez PY - 2011/2/3/pubmed PY - 2011/6/23/medline KW - Narcolepsy KW - cardioreactivity KW - heart rate KW - hypocretin KW - periodic leg movements SP - 219 EP - 23 JF - Sleep JO - Sleep VL - 34 IS - 2 N2 - STUDY OBJECTIVES: To test the hypothesis of autonomic nervous system dysfunction in patients with narcolepsy-cataplexy (NC) by assessing the physiologic activations associated with periodic limb movements during sleep (PLMS). DESIGN: Sleep and heart rate (HR) were recorded during 1 night of polysomnography. SETTING: Data were collected at the Sleep Disorders Center, Sacre-Coeur Hospital, Montreal, Canada. PARTICIPANTS: Data from 14 patients with NC (6 men, 8 women, mean age: 52.5 ± 11.9 years) were compared with data from 14 healthy control subjects matched for age and sex. INTERVENTIONS: NA. MEASUREMENTS AND RESULTS: Analyses included sleep stages, PLMS, microarousals, RR intervals converted into beats per minute on segments lasting 25 heartbeats (10 RR intervals before PLMS and 15 after), and cardiac-activation amplitudes. A Group-by-Heartbeat interaction was noted for PLMS without microarousals; the patients had a tachycardia of lower amplitude and a delayed and lower-amplitude bradycardia, compared with normal control subjects. Similar significant HR modifications were observed for PLMS with microarousals between patients with NC and control subjects. Patients with NC had a reduced magnitude of cardiac activation associated with PLMS with and without microarousals, as compared with control subjects. A negative correlation was noted between cardiac-activation amplitude and age in patients with NC, but no correlation with PLMS index was found in either patients with NC or control subjects. CONCLUSION: A significant reduction in the amplitude of PLMS-related HR responses in both tachycardia and bradycardia was found in patients with NC. These findings favor the physiologic relevance of the action of hypocretin on autonomic function that may be of clinical significance, i.e., increasing the risk of cardiovascular diseases. SN - 1550-9109 UR - https://www.unboundmedicine.com/medline/citation/21286243/Autonomic_response_to_periodic_leg_movements_during_sleep_in_narcolepsy_cataplexy_ L2 - https://academic.oup.com/sleep/article-lookup/doi/10.1093/sleep/34.2.219 DB - PRIME DP - Unbound Medicine ER -