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Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions.
Org Lett. 2011 Mar 04; 13(5):832-5.OL

Abstract

Highly enantioselective chiral bifunctional thiourea catalyzed asymmetric tandem reactions for synthesis of substituted tetrahydroquinolines are described. Substituted tetrahydroquinolines were given in good yields (up to 98%), high enantioselectivities (up to >99% ee), and diastereoselectivities (up to 20:1 dr).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Jia ZX
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P R China.
Luo YC
No affiliation info available
Xu PF
No affiliation info available

MeSH

CatalysisCombinatorial Chemistry TechniquesMolecular StructureQuinolinesStereoisomerismThiourea

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21288007

Citation

Jia, Zhen-Xin, et al. "Highly Enantioselective Synthesis of Polysubstituted Tetrahydroquinolines Via Organocatalytic Michael/Aza-Henry Tandem Reactions." Organic Letters, vol. 13, no. 5, 2011, pp. 832-5.
Jia ZX, Luo YC, Xu PF. Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions. Org Lett. 2011;13(5):832-5.
Jia, Z. X., Luo, Y. C., & Xu, P. F. (2011). Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions. Organic Letters, 13(5), 832-5. https://doi.org/10.1021/ol103069d
Jia ZX, Luo YC, Xu PF. Highly Enantioselective Synthesis of Polysubstituted Tetrahydroquinolines Via Organocatalytic Michael/Aza-Henry Tandem Reactions. Org Lett. 2011 Mar 4;13(5):832-5. PubMed PMID: 21288007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly enantioselective synthesis of polysubstituted tetrahydroquinolines via organocatalytic Michael/Aza-Henry tandem reactions. AU - Jia,Zhen-Xin, AU - Luo,Yong-Chun, AU - Xu,Peng-Fei, Y1 - 2011/02/02/ PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/5/7/medline SP - 832 EP - 5 JF - Organic letters JO - Org Lett VL - 13 IS - 5 N2 - Highly enantioselective chiral bifunctional thiourea catalyzed asymmetric tandem reactions for synthesis of substituted tetrahydroquinolines are described. Substituted tetrahydroquinolines were given in good yields (up to 98%), high enantioselectivities (up to >99% ee), and diastereoselectivities (up to 20:1 dr). SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/21288007/Highly_enantioselective_synthesis_of_polysubstituted_tetrahydroquinolines_via_organocatalytic_Michael/Aza_Henry_tandem_reactions_ L2 - https://doi.org/10.1021/ol103069d DB - PRIME DP - Unbound Medicine ER -