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Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes.
J Phys Chem A. 2011 Feb 24; 115(7):1234-42.JP

Abstract

Solutions of about 0.25 mM of the β-blocker metoprolol tartrate (100 mg L(-1) total organic carbon) with 0.5 mM Fe(2+) in the presence and absence of 0.1 mM Cu(2+) of pH 3.0 have been comparatively degraded under electro-Fenton (EF) and photoelectro-Fenton (PEF) conditions. The electrolyses were carried out with two systems: (i) a single cell with a boron-doped diamond (BDD) anode and an air-diffusion cathode (ADE) for H(2)O(2) electrogeneration and (ii) a combined cell with a BDD/ADE pair coupled with a Pt/carbon felt (CF) cell. Overall mineralization was reached in all PEF treatments using both systems due to the efficient production of hydroxyl radical ((•)OH) from Fenton's reaction induced by UVA light and the quick photolysis of Fe(III) carboxylate complexes formed. In EF, the combined cell was much more potent than the single one by the larger (•)OH generation from the continuous Fe(2+) regeneration at the CF cathode, accelerating the oxidation of organics. However, almost total mineralization in EF was feasible using the combined cell in the presence of 0.1 mM Cu(2+), because of the parallel quick oxidation of Cu(II) carboxylate complexes by (•)OH. Metoprolol decay always followed a pseudo-first-order reaction. Aromatic products related to consecutive hydroxylation/oxidation reactions of metoprolol were detected by gas chromatography-mass spectrometry. The evolution of the aromatic 4-(2-methoxyethyl)phenol and generated carboxylic acids was followed by HPLC. The degradation rate and mineralization degree of metoprolol tartrate were limited by the removal of Fe(III) and Cu(II) complexes of ultimate carboxylic acids such as formic, oxalic, and oxamic. NH(4)(+) ion and to a lesser extent NO(3)(-) ion were released in all treatments, being quantified by ionic chromatography.

Authors+Show Affiliations

Laboratori d'Electroquímica dels Materials i del Medi Ambient, Departament de Química Física, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21288029

Citation

Isarain-Chávez, Eloy, et al. "Mineralization of Metoprolol By electro-Fenton and photoelectro-Fenton Processes." The Journal of Physical Chemistry. A, vol. 115, no. 7, 2011, pp. 1234-42.
Isarain-Chávez E, Garrido JA, Rodríguez RM, et al. Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes. J Phys Chem A. 2011;115(7):1234-42.
Isarain-Chávez, E., Garrido, J. A., Rodríguez, R. M., Centellas, F., Arias, C., Cabot, P. L., & Brillas, E. (2011). Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes. The Journal of Physical Chemistry. A, 115(7), 1234-42. https://doi.org/10.1021/jp110753r
Isarain-Chávez E, et al. Mineralization of Metoprolol By electro-Fenton and photoelectro-Fenton Processes. J Phys Chem A. 2011 Feb 24;115(7):1234-42. PubMed PMID: 21288029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes. AU - Isarain-Chávez,Eloy, AU - Garrido,José Antonio, AU - Rodríguez,Rosa María, AU - Centellas,Francesc, AU - Arias,Conchita, AU - Cabot,Pere Lluís, AU - Brillas,Enric, Y1 - 2011/02/02/ PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/6/2/medline SP - 1234 EP - 42 JF - The journal of physical chemistry. A JO - J Phys Chem A VL - 115 IS - 7 N2 - Solutions of about 0.25 mM of the β-blocker metoprolol tartrate (100 mg L(-1) total organic carbon) with 0.5 mM Fe(2+) in the presence and absence of 0.1 mM Cu(2+) of pH 3.0 have been comparatively degraded under electro-Fenton (EF) and photoelectro-Fenton (PEF) conditions. The electrolyses were carried out with two systems: (i) a single cell with a boron-doped diamond (BDD) anode and an air-diffusion cathode (ADE) for H(2)O(2) electrogeneration and (ii) a combined cell with a BDD/ADE pair coupled with a Pt/carbon felt (CF) cell. Overall mineralization was reached in all PEF treatments using both systems due to the efficient production of hydroxyl radical ((•)OH) from Fenton's reaction induced by UVA light and the quick photolysis of Fe(III) carboxylate complexes formed. In EF, the combined cell was much more potent than the single one by the larger (•)OH generation from the continuous Fe(2+) regeneration at the CF cathode, accelerating the oxidation of organics. However, almost total mineralization in EF was feasible using the combined cell in the presence of 0.1 mM Cu(2+), because of the parallel quick oxidation of Cu(II) carboxylate complexes by (•)OH. Metoprolol decay always followed a pseudo-first-order reaction. Aromatic products related to consecutive hydroxylation/oxidation reactions of metoprolol were detected by gas chromatography-mass spectrometry. The evolution of the aromatic 4-(2-methoxyethyl)phenol and generated carboxylic acids was followed by HPLC. The degradation rate and mineralization degree of metoprolol tartrate were limited by the removal of Fe(III) and Cu(II) complexes of ultimate carboxylic acids such as formic, oxalic, and oxamic. NH(4)(+) ion and to a lesser extent NO(3)(-) ion were released in all treatments, being quantified by ionic chromatography. SN - 1520-5215 UR - https://www.unboundmedicine.com/medline/citation/21288029/Mineralization_of_metoprolol_by_electro_Fenton_and_photoelectro_Fenton_processes_ L2 - https://doi.org/10.1021/jp110753r DB - PRIME DP - Unbound Medicine ER -