Tags

Type your tag names separated by a space and hit enter

Acute effects of coffee on QT interval in healthy subjects.
Nutr J. 2011 Feb 02; 10:15.NJ

Abstract

The coronary endothelial function is recognized to have an important role in the physiology of the diastolic ventricular relaxation, a phase of the heart cycle that influences the electrocardiographic QT interval. Endothelial function is investigated in vivo by flow mediated dilation (FMD) in the brachial artery and has proven to be a strong predictor of both coronary endothelial function and cardiovascular events. It has been reported that coffee acutely induces FMD changes. In particular, the brachial artery FMD seems to decrease after caffeinated coffee (CC) and to increase after decaffeinated coffee (DC) ingestion. Since the cardiovascular effects of coffee are still a debated matter, this study aimed at investigating with a randomized, double-blind crossover design, if the QT interval of adult healthy subjects (19 males and 21 females) changes in the hour following CC or DC ingestion. Both systolic and diastolic blood pressure were higher in the hour following the ingestion of CC; the heart rate significantly increased 30 minutes after CC ingestion. A significant increase of the QT duration was observed one hour after DC ingestion (398.9 ± 3.8 vs 405.3 ± 3.7 msec; P < 0.05), not after CC. The QT interval corrected for heart rate did not significantly change following CC or DC ingestion. In conclusion, despite CC and DC previously demonstrated to influence the FMD they do not seem to induce a significant unfavourable acute change of the left ventricular repolarization. Further investigations are required to elucidate the effects of coffee in subjects with cardiovascular diseases.

Authors+Show Affiliations

Department of Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Faculty of Medicine, University of Palermo, Italy. silbus@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21288364

Citation

Buscemi, Silvio, et al. "Acute Effects of Coffee On QT Interval in Healthy Subjects." Nutrition Journal, vol. 10, 2011, p. 15.
Buscemi S, Mattina A, Tranchina MR, et al. Acute effects of coffee on QT interval in healthy subjects. Nutr J. 2011;10:15.
Buscemi, S., Mattina, A., Tranchina, M. R., & Verga, S. (2011). Acute effects of coffee on QT interval in healthy subjects. Nutrition Journal, 10, 15. https://doi.org/10.1186/1475-2891-10-15
Buscemi S, et al. Acute Effects of Coffee On QT Interval in Healthy Subjects. Nutr J. 2011 Feb 2;10:15. PubMed PMID: 21288364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of coffee on QT interval in healthy subjects. AU - Buscemi,Silvio, AU - Mattina,Alessandro, AU - Tranchina,Maria Rosaria, AU - Verga,Salvatore, Y1 - 2011/02/02/ PY - 2010/11/05/received PY - 2011/02/02/accepted PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/4/22/medline SP - 15 EP - 15 JF - Nutrition journal JO - Nutr J VL - 10 N2 - The coronary endothelial function is recognized to have an important role in the physiology of the diastolic ventricular relaxation, a phase of the heart cycle that influences the electrocardiographic QT interval. Endothelial function is investigated in vivo by flow mediated dilation (FMD) in the brachial artery and has proven to be a strong predictor of both coronary endothelial function and cardiovascular events. It has been reported that coffee acutely induces FMD changes. In particular, the brachial artery FMD seems to decrease after caffeinated coffee (CC) and to increase after decaffeinated coffee (DC) ingestion. Since the cardiovascular effects of coffee are still a debated matter, this study aimed at investigating with a randomized, double-blind crossover design, if the QT interval of adult healthy subjects (19 males and 21 females) changes in the hour following CC or DC ingestion. Both systolic and diastolic blood pressure were higher in the hour following the ingestion of CC; the heart rate significantly increased 30 minutes after CC ingestion. A significant increase of the QT duration was observed one hour after DC ingestion (398.9 ± 3.8 vs 405.3 ± 3.7 msec; P < 0.05), not after CC. The QT interval corrected for heart rate did not significantly change following CC or DC ingestion. In conclusion, despite CC and DC previously demonstrated to influence the FMD they do not seem to induce a significant unfavourable acute change of the left ventricular repolarization. Further investigations are required to elucidate the effects of coffee in subjects with cardiovascular diseases. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/21288364/Acute_effects_of_coffee_on_QT_interval_in_healthy_subjects_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-10-15 DB - PRIME DP - Unbound Medicine ER -