Tags

Type your tag names separated by a space and hit enter

Desquamating apoptotic variant of high-grade prostatic intraepithelial neoplasia: a possible precursor of intraductal prostatic carcinoma.
Hum Pathol. 2011 Jun; 42(6):892-5.HP

Abstract

Various patterns of high-grade prostatic intraepithelial neoplasia have been have been described, many of which show morphologic similarity to patterns of prostatic intraductal carcinoma, which is thought to develop either directly from high-grade prostatic intraepithelial neoplasia or by invasion of existing ducts by Gleason pattern 4 or 5 carcinoma. We document a rare and previously unreported "desquamating apoptotic variant" of high-grade prostatic intraepithelial neoplasia where desquamating cells containing apoptotic nuclear material coalesce in the gland lumens to form basophilic intraluminal masses in up to one third of involved acini. This lesion shares features of both high-grade prostatic intraepithelial neoplasia and prostatic intraductal carcinoma and supports the hypothesis that some forms of prostatic intraductal carcinoma evolve directly from high-grade prostatic intraepithelial neoplasia.

Authors+Show Affiliations

Uropath Pty Ltd and School of Pathology and Laboratory Medicine, University of Western Australia, Perth 6007, Western Australia. ronnie@uropath.com.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21288556

Citation

Cohen, Ronald J., et al. "Desquamating Apoptotic Variant of High-grade Prostatic Intraepithelial Neoplasia: a Possible Precursor of Intraductal Prostatic Carcinoma." Human Pathology, vol. 42, no. 6, 2011, pp. 892-5.
Cohen RJ, O'Brien BA, Wheeler TM. Desquamating apoptotic variant of high-grade prostatic intraepithelial neoplasia: a possible precursor of intraductal prostatic carcinoma. Hum Pathol. 2011;42(6):892-5.
Cohen, R. J., O'Brien, B. A., & Wheeler, T. M. (2011). Desquamating apoptotic variant of high-grade prostatic intraepithelial neoplasia: a possible precursor of intraductal prostatic carcinoma. Human Pathology, 42(6), 892-5. https://doi.org/10.1016/j.humpath.2010.09.008
Cohen RJ, O'Brien BA, Wheeler TM. Desquamating Apoptotic Variant of High-grade Prostatic Intraepithelial Neoplasia: a Possible Precursor of Intraductal Prostatic Carcinoma. Hum Pathol. 2011;42(6):892-5. PubMed PMID: 21288556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Desquamating apoptotic variant of high-grade prostatic intraepithelial neoplasia: a possible precursor of intraductal prostatic carcinoma. AU - Cohen,Ronald J, AU - O'Brien,Beverley A, AU - Wheeler,Thomas M, Y1 - 2011/02/01/ PY - 2010/08/04/received PY - 2010/09/08/revised PY - 2010/09/08/accepted PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/7/13/medline SP - 892 EP - 5 JF - Human pathology JO - Hum Pathol VL - 42 IS - 6 N2 - Various patterns of high-grade prostatic intraepithelial neoplasia have been have been described, many of which show morphologic similarity to patterns of prostatic intraductal carcinoma, which is thought to develop either directly from high-grade prostatic intraepithelial neoplasia or by invasion of existing ducts by Gleason pattern 4 or 5 carcinoma. We document a rare and previously unreported "desquamating apoptotic variant" of high-grade prostatic intraepithelial neoplasia where desquamating cells containing apoptotic nuclear material coalesce in the gland lumens to form basophilic intraluminal masses in up to one third of involved acini. This lesion shares features of both high-grade prostatic intraepithelial neoplasia and prostatic intraductal carcinoma and supports the hypothesis that some forms of prostatic intraductal carcinoma evolve directly from high-grade prostatic intraepithelial neoplasia. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/21288556/Desquamating_apoptotic_variant_of_high_grade_prostatic_intraepithelial_neoplasia:_a_possible_precursor_of_intraductal_prostatic_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(10)00366-7 DB - PRIME DP - Unbound Medicine ER -