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Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes.
Clin Nutr 2011; 30(3):359-64CN

Abstract

BACKGROUND & AIMS

This study was undertaken to assess magnesium intake and magnesium status in patients with type 2 diabetes, and to identify the parameters that best predict alterations in fasting glucose and plasma magnesium.

METHODS

A cross-sectional study was carried out in patients with type 2 diabetes (n = 51; 53.6 ± 10.5 y) selected within the inclusion factors, at the University Hospital Onofre Lopes. Magnesium intake was assessed by three 24-h recalls. Urine, plasma and erythrocytes magnesium, fasting and 2-h postprandial glucose, HbA1, microalbuminuria, proteinuria, and serum and urine creatinine were measured.

RESULTS

Mean magnesium intake (9.37 ± 1.76 mmol/d), urine magnesium (2.80 ± 1.51 mmol/d), plasma magnesium (0.71 ± 0.08 mmol/L) and erythrocyte magnesium (1.92 ± 0.23 mmol/L) levels were low. Seventy-seven percent of participants presented one or more magnesium status parameters below the cut-off points of 3.00 mmol/L for urine, 0.75 mmol/L for plasma and 1.65 mmol/L for erythrocytes. Subjects presented poor blood glucose control with fasting glucose of 8.1 ± 3.7 mmol/L, 2-h postprandial glucose of 11.1 ± 5.1 mmol/L, and HbA1 of 11.4 ± 3.0%. The parameters that influenced fasting glucose were urine, plasma and dietary magnesium, while plasma magnesium was influenced by creatinine clearance.

CONCLUSIONS

Magnesium status was influenced by kidney depuration and was altered in patients with type 2 diabetes, and magnesium showed to play an important role in blood glucose control.

Authors+Show Affiliations

Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. cristianehermes@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21288611

Citation

Sales, Cristiane Hermes, et al. "Influence of Magnesium Status and Magnesium Intake On the Blood Glucose Control in Patients With Type 2 Diabetes." Clinical Nutrition (Edinburgh, Scotland), vol. 30, no. 3, 2011, pp. 359-64.
Sales CH, Pedrosa LF, Lima JG, et al. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clin Nutr. 2011;30(3):359-64.
Sales, C. H., Pedrosa, L. F., Lima, J. G., Lemos, T. M., & Colli, C. (2011). Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clinical Nutrition (Edinburgh, Scotland), 30(3), pp. 359-64. doi:10.1016/j.clnu.2010.12.011.
Sales CH, et al. Influence of Magnesium Status and Magnesium Intake On the Blood Glucose Control in Patients With Type 2 Diabetes. Clin Nutr. 2011;30(3):359-64. PubMed PMID: 21288611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. AU - Sales,Cristiane Hermes, AU - Pedrosa,Lucia Fátima Campos, AU - Lima,Josivan Gomes, AU - Lemos,Telma Maria Araújo Moura, AU - Colli,Célia, Y1 - 2011/02/01/ PY - 2010/08/21/received PY - 2010/11/23/revised PY - 2010/12/23/accepted PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/10/4/medline SP - 359 EP - 64 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 30 IS - 3 N2 - BACKGROUND & AIMS: This study was undertaken to assess magnesium intake and magnesium status in patients with type 2 diabetes, and to identify the parameters that best predict alterations in fasting glucose and plasma magnesium. METHODS: A cross-sectional study was carried out in patients with type 2 diabetes (n = 51; 53.6 ± 10.5 y) selected within the inclusion factors, at the University Hospital Onofre Lopes. Magnesium intake was assessed by three 24-h recalls. Urine, plasma and erythrocytes magnesium, fasting and 2-h postprandial glucose, HbA1, microalbuminuria, proteinuria, and serum and urine creatinine were measured. RESULTS: Mean magnesium intake (9.37 ± 1.76 mmol/d), urine magnesium (2.80 ± 1.51 mmol/d), plasma magnesium (0.71 ± 0.08 mmol/L) and erythrocyte magnesium (1.92 ± 0.23 mmol/L) levels were low. Seventy-seven percent of participants presented one or more magnesium status parameters below the cut-off points of 3.00 mmol/L for urine, 0.75 mmol/L for plasma and 1.65 mmol/L for erythrocytes. Subjects presented poor blood glucose control with fasting glucose of 8.1 ± 3.7 mmol/L, 2-h postprandial glucose of 11.1 ± 5.1 mmol/L, and HbA1 of 11.4 ± 3.0%. The parameters that influenced fasting glucose were urine, plasma and dietary magnesium, while plasma magnesium was influenced by creatinine clearance. CONCLUSIONS: Magnesium status was influenced by kidney depuration and was altered in patients with type 2 diabetes, and magnesium showed to play an important role in blood glucose control. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/21288611/Influence_of_magnesium_status_and_magnesium_intake_on_the_blood_glucose_control_in_patients_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(11)00003-3 DB - PRIME DP - Unbound Medicine ER -