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    Heterogeneity in the composition of marijuana seized in California.

    Abstract

    BACKGROUND

    Marijuana contains multiple cannabinoids. Most attention is given to delta-9-tetrahydrocannabinol (THC) which produces euphoria and in some cases anxiety and panic reactions. Research suggests that another cannabinoid, cannabidiol (CBD), may offset some of these effects. Thus, there is growing interest in the health consequences of the THC to CBD ratio for marijuana.

    METHODS

    Using data from over 5000 marijuana samples in California from 1996 to 2008, we examine changes in the median THC-level, median CBD-level, and median THC:CBD-ratio.

    RESULTS

    The median THC-level and median THC:CBD-ratio have dramatically increased for seizures in California, particularly north of the Mexican border.

    CONCLUSION

    Research on the consequences of the THC:CBD ratio should continue, especially as more attention is devoted to thinking about how to regulate marijuana for medical and recreational use. Researchers should also consider the lack of uniformity in the chemical composition of marijuana when evaluating its health effects.

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    Authors+Show Affiliations

    Burgdorf JR
    ,

    Pardee RAND Graduate School, RAND Corporation, 1776 Main Street, Santa Monica, CA 90401, USA.

    Kilmer B
    ,
    Pacula RL

    Source

    Drug and alcohol dependence 117:1 2011 Aug 1 pg 59-61

    MeSH

    California
    Cannabidiol
    Cannabis
    Databases, Factual
    Dronabinol
    Humans
    Law Enforcement
    Psychotropic Drugs

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21288662

    Citation

    TY - JOUR T1 - Heterogeneity in the composition of marijuana seized in California. AU - Burgdorf,James Richard, AU - Kilmer,Beau, AU - Pacula,Rosalie Liccardo, Y1 - 2011/02/01/ PY - 2010/9/10/received PY - 2010/11/16/revised PY - 2010/11/24/accepted PY - 2011/2/1/aheadofprint PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2012/1/18/medline SP - 59 EP - 61 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 117 IS - 1 N2 - BACKGROUND: Marijuana contains multiple cannabinoids. Most attention is given to delta-9-tetrahydrocannabinol (THC) which produces euphoria and in some cases anxiety and panic reactions. Research suggests that another cannabinoid, cannabidiol (CBD), may offset some of these effects. Thus, there is growing interest in the health consequences of the THC to CBD ratio for marijuana. METHODS: Using data from over 5000 marijuana samples in California from 1996 to 2008, we examine changes in the median THC-level, median CBD-level, and median THC:CBD-ratio. RESULTS: The median THC-level and median THC:CBD-ratio have dramatically increased for seizures in California, particularly north of the Mexican border. CONCLUSION: Research on the consequences of the THC:CBD ratio should continue, especially as more attention is devoted to thinking about how to regulate marijuana for medical and recreational use. Researchers should also consider the lack of uniformity in the chemical composition of marijuana when evaluating its health effects. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/21288662/abstract/Heterogeneity_in_the_composition_of_marijuana_seized_in_California_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0376-8716(11)00051-2 ER -