Abstract
BACKGROUND
Marijuana contains multiple cannabinoids. Most attention is given to delta-9-tetrahydrocannabinol (THC) which produces euphoria and in some cases anxiety and panic reactions. Research suggests that another cannabinoid, cannabidiol (CBD), may offset some of these effects. Thus, there is growing interest in the health consequences of the THC to CBD ratio for marijuana.
METHODS
Using data from over 5000 marijuana samples in California from 1996 to 2008, we examine changes in the median THC-level, median CBD-level, and median THC:CBD-ratio.
RESULTS
The median THC-level and median THC:CBD-ratio have dramatically increased for seizures in California, particularly north of the Mexican border.
CONCLUSION
Research on the consequences of the THC:CBD ratio should continue, especially as more attention is devoted to thinking about how to regulate marijuana for medical and recreational use. Researchers should also consider the lack of uniformity in the chemical composition of marijuana when evaluating its health effects.
TY - JOUR
T1 - Heterogeneity in the composition of marijuana seized in California.
AU - Burgdorf,James Richard,
AU - Kilmer,Beau,
AU - Pacula,Rosalie Liccardo,
Y1 - 2011/02/01/
PY - 2010/09/10/received
PY - 2010/11/16/revised
PY - 2010/11/24/accepted
PY - 2011/2/4/entrez
PY - 2011/2/4/pubmed
PY - 2012/1/18/medline
SP - 59
EP - 61
JF - Drug and alcohol dependence
JO - Drug Alcohol Depend
VL - 117
IS - 1
N2 - BACKGROUND: Marijuana contains multiple cannabinoids. Most attention is given to delta-9-tetrahydrocannabinol (THC) which produces euphoria and in some cases anxiety and panic reactions. Research suggests that another cannabinoid, cannabidiol (CBD), may offset some of these effects. Thus, there is growing interest in the health consequences of the THC to CBD ratio for marijuana. METHODS: Using data from over 5000 marijuana samples in California from 1996 to 2008, we examine changes in the median THC-level, median CBD-level, and median THC:CBD-ratio. RESULTS: The median THC-level and median THC:CBD-ratio have dramatically increased for seizures in California, particularly north of the Mexican border. CONCLUSION: Research on the consequences of the THC:CBD ratio should continue, especially as more attention is devoted to thinking about how to regulate marijuana for medical and recreational use. Researchers should also consider the lack of uniformity in the chemical composition of marijuana when evaluating its health effects.
SN - 1879-0046
UR - https://www.unboundmedicine.com/medline/citation/21288662/abstract/Heterogeneity_in_the_composition_of_marijuana_seized_in_California_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(11)00051-2
DB - PRIME
DP - Unbound Medicine
ER -