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Subjective and physiological effects after controlled Sativex and oral THC administration.
Clin Pharmacol Ther. 2011 Mar; 89(3):400-7.CP

Abstract

Sativex is a cannabis-plant extract delivering nearly 1:1 Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that CBD attenuates THC-induced tachycardia, anxiety, and euphoria. In this study, pharmacodynamic effects were compared over 10.5 h in nine cannabis smokers randomly assigned to receive placebo, 5 and 15 mg oral synthetic THC, and low (5.4 mg THC, 5.0 mg CBD) and high (16.2 mg THC, 15.0 mg CBD) doses of Sativex. At therapeutic doses, no substantial CBD-induced modulation of THC's effects was evident. Oral THC and Sativex produced similar, clinically insignificant increases in heart rate, anxiety, and "good drug effects" with no serious adverse events. Oral and oromucosal THC have slower absorption, lower rate of THC delivery to the brain, and fewer associated adverse events as compared with smoked cannabis. These results indicate that Sativex has a pharmacodynamic safety profile comparable to that of oral THC at low, therapeutic doses.

Authors+Show Affiliations

Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

21289620

Citation

Karschner, E L., et al. "Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration." Clinical Pharmacology and Therapeutics, vol. 89, no. 3, 2011, pp. 400-7.
Karschner EL, Darwin WD, McMahon RP, et al. Subjective and physiological effects after controlled Sativex and oral THC administration. Clin Pharmacol Ther. 2011;89(3):400-7.
Karschner, E. L., Darwin, W. D., McMahon, R. P., Liu, F., Wright, S., Goodwin, R. S., & Huestis, M. A. (2011). Subjective and physiological effects after controlled Sativex and oral THC administration. Clinical Pharmacology and Therapeutics, 89(3), 400-7. https://doi.org/10.1038/clpt.2010.318
Karschner EL, et al. Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration. Clin Pharmacol Ther. 2011;89(3):400-7. PubMed PMID: 21289620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subjective and physiological effects after controlled Sativex and oral THC administration. AU - Karschner,E L, AU - Darwin,W D, AU - McMahon,R P, AU - Liu,F, AU - Wright,S, AU - Goodwin,R S, AU - Huestis,M A, Y1 - 2011/02/02/ PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/4/5/medline SP - 400 EP - 7 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 89 IS - 3 N2 - Sativex is a cannabis-plant extract delivering nearly 1:1 Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that CBD attenuates THC-induced tachycardia, anxiety, and euphoria. In this study, pharmacodynamic effects were compared over 10.5 h in nine cannabis smokers randomly assigned to receive placebo, 5 and 15 mg oral synthetic THC, and low (5.4 mg THC, 5.0 mg CBD) and high (16.2 mg THC, 15.0 mg CBD) doses of Sativex. At therapeutic doses, no substantial CBD-induced modulation of THC's effects was evident. Oral THC and Sativex produced similar, clinically insignificant increases in heart rate, anxiety, and "good drug effects" with no serious adverse events. Oral and oromucosal THC have slower absorption, lower rate of THC delivery to the brain, and fewer associated adverse events as compared with smoked cannabis. These results indicate that Sativex has a pharmacodynamic safety profile comparable to that of oral THC at low, therapeutic doses. SN - 1532-6535 UR - https://www.unboundmedicine.com/medline/citation/21289620/Subjective_and_physiological_effects_after_controlled_Sativex_and_oral_THC_administration_ L2 - https://doi.org/10.1038/clpt.2010.318 DB - PRIME DP - Unbound Medicine ER -