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Cannabinoids: potential targets for bladder dysfunction.
Handb Exp Pharmacol 2011; (202):425-51HE

Abstract

Cannabinoids are the active chemical components of Cannabis sativa (marijuana). The medical use of cannabis goes back over 5,000 years. Cannabinoids produce a very wide array of central and peripheral effects, some of which may have beneficial clinical applications. The discovery of cannabinoid receptors has spawned great interest within the pharmaceutical industry with the hopes of capitalizing on the beneficial effects of cannabis without the unwanted psychotropic effects on the central and peripheral nervous system. This chapter presents an overview of the pharmacology of cannabinoids and their derivatives. It reviews the current literature on central and peripheral cannabinoid receptors as related to effects on the lower urinary tract and the role of these receptors in normal and abnormal urinary tract function. An objective evaluation of the published results of clinical trials of cannabis extracts for the treatment of bladder dysfunction resulting from multiple sclerosis is also presented. It is clear that cannabinoid receptors are present in the lower urinary tract as well as spinal and higher centers involved in lower urinary tract control. Systemic cannabinoids have effects on the lower urinary tract that may be able to become clinically useful; however, a much greater understanding of the mechanisms of cannabinoid receptors in control of the human lower urinary tract is necessary to facilitate development of novel cannabinoid drugs for treatment of pelvic disorders.

Authors+Show Affiliations

Temple University School of Medicine, Philadelphia, PA 19140-5104, USA. rugg101@verizon.net

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21290238

Citation

Ruggieri, Michael R.. "Cannabinoids: Potential Targets for Bladder Dysfunction." Handbook of Experimental Pharmacology, 2011, pp. 425-51.
Ruggieri MR. Cannabinoids: potential targets for bladder dysfunction. Handb Exp Pharmacol. 2011.
Ruggieri, M. R. (2011). Cannabinoids: potential targets for bladder dysfunction. Handbook of Experimental Pharmacology, (202), pp. 425-51. doi:10.1007/978-3-642-16499-6_20.
Ruggieri MR. Cannabinoids: Potential Targets for Bladder Dysfunction. Handb Exp Pharmacol. 2011;(202)425-51. PubMed PMID: 21290238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabinoids: potential targets for bladder dysfunction. A1 - Ruggieri,Michael R,Sr PY - 2011/2/4/entrez PY - 2011/2/4/pubmed PY - 2011/5/13/medline SP - 425 EP - 51 JF - Handbook of experimental pharmacology JO - Handb Exp Pharmacol IS - 202 N2 - Cannabinoids are the active chemical components of Cannabis sativa (marijuana). The medical use of cannabis goes back over 5,000 years. Cannabinoids produce a very wide array of central and peripheral effects, some of which may have beneficial clinical applications. The discovery of cannabinoid receptors has spawned great interest within the pharmaceutical industry with the hopes of capitalizing on the beneficial effects of cannabis without the unwanted psychotropic effects on the central and peripheral nervous system. This chapter presents an overview of the pharmacology of cannabinoids and their derivatives. It reviews the current literature on central and peripheral cannabinoid receptors as related to effects on the lower urinary tract and the role of these receptors in normal and abnormal urinary tract function. An objective evaluation of the published results of clinical trials of cannabis extracts for the treatment of bladder dysfunction resulting from multiple sclerosis is also presented. It is clear that cannabinoid receptors are present in the lower urinary tract as well as spinal and higher centers involved in lower urinary tract control. Systemic cannabinoids have effects on the lower urinary tract that may be able to become clinically useful; however, a much greater understanding of the mechanisms of cannabinoid receptors in control of the human lower urinary tract is necessary to facilitate development of novel cannabinoid drugs for treatment of pelvic disorders. SN - 0171-2004 UR - https://www.unboundmedicine.com/medline/citation/21290238/Cannabinoids:_potential_targets_for_bladder_dysfunction_ L2 - https://dx.doi.org/10.1007/978-3-642-16499-6_20 DB - PRIME DP - Unbound Medicine ER -